STRINGSTRING
SESN2 SESN2 SH3GLB1 SH3GLB1 RNF152 RNF152 MTOR MTOR PRKD1 PRKD1 TFEB TFEB CDKN1A CDKN1A RRAGB RRAGB EIF2AK3 EIF2AK3 RRAGD RRAGD KPTN KPTN DAP DAP MAP3K5 MAP3K5 EIF2S1 EIF2S1 SESN3 SESN3 WDR59 WDR59 SZT2 SZT2 DEPDC5 DEPDC5 C12orf66 C12orf66 A0A287ANP8_PIG A0A287ANP8_PIG EIF2AK4 EIF2AK4 GCN1 GCN1 BMT2 BMT2 ATF2 ATF2 EIF2AK2 EIF2AK2 ATF4 ATF4 MAPK3 MAPK3 NPRL3 NPRL3 FAS FAS SESN1 SESN1 FLCN FLCN LARS1 LARS1 MAPK1 MAPK1 ITFG2 ITFG2 MIOS MIOS DAPL1 DAPL1 ATF3 ATF3 WDR24 WDR24
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN2Sestrin 2. (471 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
RNF152E3 ubiquitin-protein ligase RNF152 isoform X1. (203 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
TFEBTranscription factor EB. (451 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
RRAGBRas-related GTP-binding protein B long isoform. (374 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
KPTNKaptin, actin binding protein. (436 aa)
DAPUncharacterized protein. (102 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1425 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa)
SESN3Sestrin-3 isoform 1. (492 aa)
WDR59WD repeat domain 59. (938 aa)
SZT2SZT2 subunit of KICSTOR complex. (3436 aa)
DEPDC5DEP domain-containing protein. (1593 aa)
C12orf66Chromosome 12 open reading frame 66. (503 aa)
A0A287ANP8_PIGUncharacterized protein. (89 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1633 aa)
GCN1GCN1 activator of EIF2AK4. (2679 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
ATF4Activating transcription factor 4. (329 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (611 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa)
SESN1Sestrin 1. (582 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1175 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (455 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
DAPL1Uncharacterized protein. (97 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (250 aa)
WDR24GATOR complex protein WDR24. (790 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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