(22 nodes) Leukocyte degranulation network (Sus scrofa)

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Your Input:
	GRP	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (146 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1274 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa)
	RAB27A	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (492 aa)
	SYK	40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
	CLNK	Cytokine dependent hematopoietic cell linker. (446 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
	CHGA	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. (596 aa)
	MILR1	Mast cell immunoglobulin like receptor 1. (340 aa)
	RABGEF1	Uncharacterized protein. (503 aa)
	PTGDS	Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (297 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (189 aa)
	UNC13D	Unc-13 homolog D. (1090 aa)
	PLA2G3	Phospholipase A2 group III. (501 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	NKG7	Uncharacterized protein. (165 aa)
	RAB44	RAB44, member RAS oncogene family. (984 aa)
	S100A13	S_100 domain-containing protein; Belongs to the S-100 family. (209 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCR	SNAP23	ENSSSCP00000043635	ENSSSCP00000043345	BCR activator of RhoGEF and GTPase.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.400
CHGA	GRP	ENSSSCP00000072459	ENSSSCP00000045701	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family.	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	0.449
GRP	CHGA	ENSSSCP00000045701	ENSSSCP00000072459	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family.	0.449
KIT	SYK	ENSSSCP00000066488	ENSSSCP00000033634	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...]	0.447
RAB27A	SNAP23	ENSSSCP00000041641	ENSSSCP00000043345	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.503
RAB27A	STXBP3	ENSSSCP00000041641	ENSSSCP00000007301	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	0.460
RAB27A	UNC13D	ENSSSCP00000041641	ENSSSCP00000018223	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Unc-13 homolog D.	0.576
RAB27A	VAMP7	ENSSSCP00000041641	ENSSSCP00000042509	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.473
RABGEF1	VAMP7	ENSSSCP00000064947	ENSSSCP00000042509	Uncharacterized protein.	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.423
SNAP23	BCR	ENSSSCP00000043345	ENSSSCP00000043635	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	BCR activator of RhoGEF and GTPase.	0.400
SNAP23	RAB27A	ENSSSCP00000043345	ENSSSCP00000041641	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	0.503
SNAP23	STXBP3	ENSSSCP00000043345	ENSSSCP00000007301	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	0.628
SNAP23	VAMP2	ENSSSCP00000043345	ENSSSCP00000071291	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	V-SNARE coiled-coil homology domain-containing protein.	0.997
SNAP23	VAMP7	ENSSSCP00000043345	ENSSSCP00000042509	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.949
STXBP3	RAB27A	ENSSSCP00000007301	ENSSSCP00000041641	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	0.460
STXBP3	SNAP23	ENSSSCP00000007301	ENSSSCP00000043345	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.628
STXBP3	VAMP2	ENSSSCP00000007301	ENSSSCP00000071291	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	V-SNARE coiled-coil homology domain-containing protein.	0.651
SYK	KIT	ENSSSCP00000033634	ENSSSCP00000066488	40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...]	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.447
UNC13D	RAB27A	ENSSSCP00000018223	ENSSSCP00000041641	Unc-13 homolog D.	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	0.576
VAMP2	SNAP23	ENSSSCP00000071291	ENSSSCP00000043345	V-SNARE coiled-coil homology domain-containing protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.997