(34 nodes) Negative regulation of viral genome replication network (Sus scrofa)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	OAS1	2'-5'-oligoadenylate synthase 1. (334 aa)
	AICDA	Activation induced cytidine deaminase. (224 aa)
	APOBEC3B	Uncharacterized protein. (418 aa)
	SRPK1	SRSF protein kinase 1. (831 aa)
	N4BP1	NEDD4-binding protein 1. (897 aa)
	LOC100359361	Uncharacterized protein. (108 aa)
	MAVS	Mitochondrial antiviral signaling protein. (532 aa)
	MPHOSPH8	M-phase phosphoprotein 8 isoform X1. (858 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (713 aa)
	OASL	2'-5'-oligoadenylate synthase-like protein isoform a. (348 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1926 aa)
	BTBD17	BTB domain containing 17. (478 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (189 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (480 aa)
	TASOR	Transcription activation suppressor. (1610 aa)
	LTF	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites. (704 aa)
	ILF3	Interleukin enhancer binding factor 3. (889 aa)
	TRIM6	Tripartite motif containing 6. (487 aa)
	MX1	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
	MORC2	MORC family CW-type zinc finger protein 2 isoform X2. (1038 aa)
	TRIM28	Tripartite motif containing 28. (868 aa)
	ZC3HAV1	Zinc finger CCCH-type antiviral protein 1 isoform 1. (894 aa)
	SLPI	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance t [...] (170 aa)
	ISG15	Ubiquitin-like modifier. (167 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1023 aa)
	SHFL	Uncharacterized protein. (286 aa)
	RSAD2	Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	SRPK2	SRSF protein kinase 2. (763 aa)
	RNASEL	2-5A-dependent ribonuclease. (743 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
	IFITM3	Uncharacterized protein. (206 aa)
	HMGA2	Uncharacterized protein. (143 aa)
	IFITM1	Uncharacterized protein. (147 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD17	EIF2AK2	ENSSSCP00000021068	ENSSSCP00000057073	BTB domain containing 17.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.729
BTBD17	OASL	ENSSSCP00000021068	ENSSSCP00000010587	BTB domain containing 17.	2'-5'-oligoadenylate synthase-like protein isoform a.	0.636
EIF2AK2	BTBD17	ENSSSCP00000057073	ENSSSCP00000021068	Eukaryotic translation initiation factor 2 alpha kinase 2.	BTB domain containing 17.	0.729
EIF2AK2	IFIH1	ENSSSCP00000057073	ENSSSCP00000044491	Eukaryotic translation initiation factor 2 alpha kinase 2.	Interferon induced with helicase C domain 1.	0.861
EIF2AK2	IFITM3	ENSSSCP00000057073	ENSSSCP00000060193	Eukaryotic translation initiation factor 2 alpha kinase 2.	Uncharacterized protein.	0.459
EIF2AK2	ILF3	ENSSSCP00000057073	ENSSSCP00000028612	Eukaryotic translation initiation factor 2 alpha kinase 2.	Interleukin enhancer binding factor 3.	0.707
EIF2AK2	ISG15	ENSSSCP00000057073	ENSSSCP00000041015	Eukaryotic translation initiation factor 2 alpha kinase 2.	Ubiquitin-like modifier.	0.991
EIF2AK2	ISG20	ENSSSCP00000057073	ENSSSCP00000021223	Eukaryotic translation initiation factor 2 alpha kinase 2.	Interferon stimulated exonuclease gene 20.	0.620
EIF2AK2	MAVS	ENSSSCP00000057073	ENSSSCP00000007605	Eukaryotic translation initiation factor 2 alpha kinase 2.	Mitochondrial antiviral signaling protein.	0.518
EIF2AK2	MX1	ENSSSCP00000057073	ENSSSCP00000029166	Eukaryotic translation initiation factor 2 alpha kinase 2.	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles.	0.994
EIF2AK2	OAS1	ENSSSCP00000057073	ENSSSCP00000064281	Eukaryotic translation initiation factor 2 alpha kinase 2.	2'-5'-oligoadenylate synthase 1.	0.809
EIF2AK2	OAS2	ENSSSCP00000057073	ENSSSCP00000010548	Eukaryotic translation initiation factor 2 alpha kinase 2.	2'-5'-oligoadenylate synthetase 2.	0.631
EIF2AK2	OASL	ENSSSCP00000057073	ENSSSCP00000010587	Eukaryotic translation initiation factor 2 alpha kinase 2.	2'-5'-oligoadenylate synthase-like protein isoform a.	0.746
EIF2AK2	RNASEL	ENSSSCP00000057073	ENSSSCP00000053969	Eukaryotic translation initiation factor 2 alpha kinase 2.	2-5A-dependent ribonuclease.	0.623
EIF2AK2	RSAD2	ENSSSCP00000057073	ENSSSCP00000052007	Eukaryotic translation initiation factor 2 alpha kinase 2.	Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...]	0.927
EIF2AK2	ZNFX1	ENSSSCP00000057073	ENSSSCP00000019450	Eukaryotic translation initiation factor 2 alpha kinase 2.	Zinc finger NFX1-type containing 1.	0.504
IFIH1	EIF2AK2	ENSSSCP00000044491	ENSSSCP00000057073	Interferon induced with helicase C domain 1.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.861
IFIH1	IFITM1	ENSSSCP00000044491	ENSSSCP00000064988	Interferon induced with helicase C domain 1.	Uncharacterized protein.	0.470
IFIH1	IFITM3	ENSSSCP00000044491	ENSSSCP00000060193	Interferon induced with helicase C domain 1.	Uncharacterized protein.	0.563
IFIH1	ISG15	ENSSSCP00000044491	ENSSSCP00000041015	Interferon induced with helicase C domain 1.	Ubiquitin-like modifier.	0.926