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| | RIOK3 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa) |
| | CDC37 | CDC37 cell division cycle 37 protein. (380 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | KLRB1 | Killer cell lectin like receptor B1. (220 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (196 aa) |
| | YTHDF3 | YTH domain-containing family protein 3 isoform b. (588 aa) |
| | PQBP1 | Polyglutamine binding protein 1. (265 aa) |
| | TIRAP | TIR domain containing adaptor protein. (243 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | TBK1 | TANK binding kinase TBK1. (729 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | MNDA | Myeloid cell nuclear differentiation antigen. (410 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | CLEC12B | C-type lectin domain-containing protein. (274 aa) |
| | AKIRIN2 | Akirin 2. (213 aa) |
| | NECTIN2 | Uncharacterized protein. (616 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (752 aa) |
| | NMI | N-myc and STAT interactor. (307 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (220 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (305 aa) |
| | METTL3 | N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa) |
| | POLR3B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa) |
| | IFI35 | Interferon induced protein 35. (284 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa) |
| | CLNK | Cytokine dependent hematopoietic cell linker. (446 aa) |
| | SLC15A4 | Solute carrier family 15 member 4. (566 aa) |
| | COCH | Cochlin isoform X2. (551 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa) |
| | LOC100519314 | C-type lectin domain-containing protein. (247 aa) |
| | ZNFX1 | Zinc finger NFX1-type containing 1. (1926 aa) |
| | FCN2 | Ficolin-2. (429 aa) |
| | LBP | Uncharacterized protein. (586 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | RNF135 | E3 ubiquitin-protein ligase RNF135 isoform 1. (423 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | DHX58 | DExH-box helicase 58. (681 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | NLRX1 | NLR family member X1 isoform X1. (975 aa) |
| | TRIM21 | Tripartite motif containing 21. (474 aa) |
| | HPX | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa) |
| | STING1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa) |
| | MATR3 | Uncharacterized protein. (897 aa) |
| | SERPING1 | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa) |
| | TKFC | ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (By similarity). Belongs to the dihydroxyacetone kinase (DAK) family. (508 aa) |
| | SH2D1A | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa) |
| | USP27X | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa) |
| | SUSD4 | Sushi domain containing 4. (460 aa) |
| | DUSP10 | Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | TRAFD1 | TRAF-type zinc finger domain containing 1. (581 aa) |
| | HMGB2 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa) |
| | POLR3D | RNA polymerase III subunit D. (398 aa) |
| | LAMP1 | Uncharacterized protein. (413 aa) |
| | TXK | Tyrosine-protein kinase. (551 aa) |
| | OTOP1 | Otopetrin 1. (612 aa) |
| | LYAR | Ly1 antibody reactive. (386 aa) |
| | ZBP1 | Uncharacterized protein. (438 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (532 aa) |
| | POLR3F | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa) |
| | POLR3C | RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa) |
| | SLAMF6 | SLAM family member 6. (321 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (797 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (913 aa) |
| | TRIM62 | E3 ubiquitin-protein ligase TRIM62 isoform 1. (475 aa) |
| | FGR | Tyrosine-protein kinase. (537 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | TYROBP | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (109 aa) |
| | N4BP1 | NEDD4-binding protein 1. (897 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa) |
| | LAG3 | Uncharacterized protein. (507 aa) |
| | KLRG1 | Killer cell lectin like receptor G1. (186 aa) |
| | LOC100523789 | C-type lectin domain-containing protein. (230 aa) |
| | LOC106507518 | C-type lectin domain-containing protein. (228 aa) |
| | ARRB2 | Arrestin beta 2. (493 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (1011 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1169 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (656 aa) |
| | TOMM70 | Translocase of outer mitochondrial membrane 70. (609 aa) |
| | YTHDF2 | YTH N6-methyladenosine RNA binding protein 2. (600 aa) |
| | LSM14A | Uncharacterized protein. (475 aa) |
| | EREG | Epiregulin. (168 aa) |
| | TTLL12 | Tubulin tyrosine ligase like 12. (604 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (292 aa) |
| | AP1G1 | AP-1 complex subunit gamma. (825 aa) |
| | STAT2 | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa) |
| | CXorf21 | Chromosome X open reading frame 21. (299 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (606 aa) |
| | HEXIM1 | HEXIM P-TEFb complex subunit 1. (348 aa) |
| | GRN | Uncharacterized protein. (656 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa) |
| | DCST1 | DC-STAMP domain containing 1. (707 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (942 aa) |
| | CADM1 | Cell adhesion molecule 1. (473 aa) |
| | IL21 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] (160 aa) |
| | CD46 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (381 aa) |
| | CD226 | CD226 antigen isoform a. (335 aa) |
| | VSIG4 | V-set and immunoglobulin domain containing 4. (399 aa) |
| | ISG15 | Ubiquitin-like modifier. (167 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa) |
| | APPL1 | Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1. (708 aa) |
| | SFPQ | Splicing factor, proline-and glutamine-rich isoform X1. (702 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (560 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CRTAM | Cytotoxic and regulatory T cell molecule. (400 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | PLA2G5 | Phospholipase A(2). (138 aa) |
| | A0A286ZWW0_PIG | AIG1-type G domain-containing protein. (321 aa) |
| | KLRK1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (221 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1846 aa) |
| | A0A286ZSP8_PIG | Gamma-interferon-inducible protein 16 isoform 1. (585 aa) |
| | LRP8 | LDL receptor related protein 8. (998 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | LOC102165642 | Uncharacterized protein. (249 aa) |
| | SYK | 40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | PSPC1 | Paraspeckle component 1 isoform 1. (521 aa) |
| | SH2D1B | SH2 domain-containing protein. (133 aa) |
| | CD96 | CD96 molecule. (571 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa) |
| | LY49 | C-type lectin domain-containing protein. (261 aa) |
| | USP15 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (924 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | ADAM8 | Disintegrin and metalloproteinase domain-containing protein 8. (835 aa) |
| | NCR3 | Uncharacterized protein. (136 aa) |
| | TRIM56 | Tripartite motif containing 56. (755 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (755 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | A0A287BRG1_PIG | Uncharacterized protein. (210 aa) |
| | IRF3 | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa) |
| | TRIM6 | Tripartite motif containing 6. (487 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (283 aa) |
| | CGAS | Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second m [...] (495 aa) |
| | KLRD1 | Killer cell lectin like receptor D1. (175 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (847 aa) |
| | RBM14 | RNA-binding protein 14 isoform 1. (669 aa) |
