STRINGSTRING
GCLC GCLC APEX1 APEX1 PRDX4 PRDX4 TXNRD3 TXNRD3 DLD DLD NQO1 NQO1 NFE2L2 NFE2L2 A0A5G2RGT7_PIG A0A5G2RGT7_PIG GLRX3 GLRX3 BOLA3 BOLA3 EGLN2 EGLN2 PRDX6 PRDX6 ERO1A ERO1A A0A287B1R4_PIG A0A287B1R4_PIG SLC2A10 SLC2A10 NFE2L1 NFE2L1 DDIT3 DDIT3 SELENOH SELENOH PRDX2 PRDX2 TXN2 TXN2 PRDX1 PRDX1 KRIT1 KRIT1 GIT1 GIT1 GSR GSR PRDX5 PRDX5 PRDX3 PRDX3 BOLA1 BOLA1 SELENOT SELENOT TXNRD2 TXNRD2 SELENOS SELENOS TXNRD1 TXNRD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCLCGlutamate--cysteine ligase catalytic subunit isoform X3. (588 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
PRDX4Peroxiredoxin 4. (276 aa)
TXNRD3Thioredoxin reductase 3; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (622 aa)
DLDDihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex) (By similarity). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA t [...] (511 aa)
NQO1Flavodoxin_2 domain-containing protein. (277 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (656 aa)
A0A5G2RGT7_PIGUncharacterized protein. (147 aa)
GLRX3Glutaredoxin 3. (461 aa)
BOLA3Uncharacterized protein; Belongs to the BolA/IbaG family. (221 aa)
EGLN2Uncharacterized protein. (257 aa)
PRDX6Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa)
ERO1AERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] (486 aa)
A0A287B1R4_PIGUncharacterized protein. (34 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (540 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (766 aa)
DDIT3DNA-damage-inducible transcript 3. (167 aa)
SELENOHUncharacterized protein. (122 aa)
PRDX2Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (237 aa)
TXN2Thioredoxin 2. (255 aa)
PRDX1Peroxiredoxin-1. (224 aa)
KRIT1Uncharacterized protein. (814 aa)
GIT1GIT ArfGAP 1. (761 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (170 aa)
PRDX3Thioredoxin domain-containing protein. (261 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (223 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
TXNRD2Uncharacterized protein. (606 aa)
SELENOSSelenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). (190 aa)
TXNRD1Thioredoxin reductase 1, cytoplasmic. (651 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.