(38 nodes) Photoreceptor cell maintenance network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDHR1	Cadherin-related family member 1 isoform 1. (856 aa)
	BBS10	Bardet-Biedl syndrome 10. (721 aa)
	MAK	Male germ cell associated kinase. (692 aa)
	SPATA7	Spermatogenesis-associated protein 7 isoform 1. (576 aa)
	CNGB1	Cyclic nucleotide-binding domain-containing protein. (1165 aa)
	CROCC	Ciliary rootlet coiled-coil, rootletin. (1966 aa)
	USP45	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (817 aa)
	CRB2	Crumbs cell polarity complex component 2. (1283 aa)
	ABCA4	ATP binding cassette subfamily A member 4. (2320 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	CDH23	Cadherin related 23. (3354 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1462 aa)
	CRB1	Crumbs cell polarity complex component 1. (1464 aa)
	RHO	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
	USH1C	USH1 protein network component harmonin. (858 aa)
	USH1G	USH1 protein network component sans. (461 aa)
	BBS12	Bardet-Biedl syndrome 12. (714 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa)
	DRAM2	DNA damage-regulated autophagy modulator protein 2 isoform X1. (266 aa)
	RP1	RP1 axonemal microtubule associated. (2142 aa)
	NPHP4	Nephrocystin 4. (1466 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (727 aa)
	TUB	Tubby-like protein; Belongs to the TUB family. (585 aa)
	NXNL2	Nucleoredoxin like 2. (156 aa)
	CLCN3	Chloride channel protein. (866 aa)
	BBS1	Bardet-Biedl syndrome 1 protein. (593 aa)
	CROCC2	Ciliary rootlet coiled-coil, rootletin family member 2. (1566 aa)
	TULP1	Tubby-like protein; Belongs to the TUB family. (535 aa)
	ADGRV1	Adhesion G protein-coupled receptor V1. (6313 aa)
	NXNL1	Nucleoredoxin like 1. (214 aa)
	PROM1	Prominin 1. (838 aa)
	CLRN1	Clarin 1. (232 aa)
	USH2A	Uncharacterized protein. (1544 aa)
	LCA5	Lebercilin isoform X1. (700 aa)
	NPHP3	TPR_REGION domain-containing protein. (1368 aa)
	CLN8	CLN8 transmembrane ER and ERGIC protein. (416 aa)
	IQCB1	IQ motif containing B1. (600 aa)
	BBS4	Uncharacterized protein. (826 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	BBS1	ENSSSCP00000007345	ENSSSCP00000035869	ATP binding cassette subfamily A member 4.	Bardet-Biedl syndrome 1 protein.	0.402
ABCA4	CDHR1	ENSSSCP00000007345	ENSSSCP00000070082	ATP binding cassette subfamily A member 4.	Cadherin-related family member 1 isoform 1.	0.428
ABCA4	NXNL1	ENSSSCP00000007345	ENSSSCP00000048152	ATP binding cassette subfamily A member 4.	Nucleoredoxin like 1.	0.584
ABCA4	RHO	ENSSSCP00000007345	ENSSSCP00000012353	ATP binding cassette subfamily A member 4.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).	0.680
ABCA4	USH2A	ENSSSCP00000007345	ENSSSCP00000051987	ATP binding cassette subfamily A member 4.	Uncharacterized protein.	0.740
ADGRV1	CDH23	ENSSSCP00000046433	ENSSSCP00000010958	Adhesion G protein-coupled receptor V1.	Cadherin related 23.	0.804
ADGRV1	CLRN1	ENSSSCP00000046433	ENSSSCP00000051069	Adhesion G protein-coupled receptor V1.	Clarin 1.	0.593
ADGRV1	USH1C	ENSSSCP00000046433	ENSSSCP00000014216	Adhesion G protein-coupled receptor V1.	USH1 protein network component harmonin.	0.703
ADGRV1	USH1G	ENSSSCP00000046433	ENSSSCP00000018247	Adhesion G protein-coupled receptor V1.	USH1 protein network component sans.	0.833
ADGRV1	USH2A	ENSSSCP00000046433	ENSSSCP00000051987	Adhesion G protein-coupled receptor V1.	Uncharacterized protein.	0.631
BBS1	ABCA4	ENSSSCP00000035869	ENSSSCP00000007345	Bardet-Biedl syndrome 1 protein.	ATP binding cassette subfamily A member 4.	0.402
BBS1	BBS10	ENSSSCP00000035869	ENSSSCP00000000554	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 10.	0.866
BBS1	BBS12	ENSSSCP00000035869	ENSSSCP00000072413	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 12.	0.599
BBS1	BBS2	ENSSSCP00000035869	ENSSSCP00000027274	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS1	BBS4	ENSSSCP00000035869	ENSSSCP00000066147	Bardet-Biedl syndrome 1 protein.	Uncharacterized protein.	0.999
BBS1	NPHP4	ENSSSCP00000035869	ENSSSCP00000023406	Bardet-Biedl syndrome 1 protein.	Nephrocystin 4.	0.410
BBS10	BBS1	ENSSSCP00000000554	ENSSSCP00000035869	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 1 protein.	0.866
BBS10	BBS12	ENSSSCP00000000554	ENSSSCP00000072413	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 12.	0.958
BBS10	BBS2	ENSSSCP00000000554	ENSSSCP00000027274	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 2 protein homolog.	0.871
BBS10	BBS4	ENSSSCP00000000554	ENSSSCP00000066147	Bardet-Biedl syndrome 10.	Uncharacterized protein.	0.823