(11 nodes) Beta-catenin destruction complex network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSK3A	Protein kinase domain-containing protein. (566 aa)
	CACYBP	Calcyclin-binding protein isoform 1. (230 aa)
	CLSTN1	Calsyntenin 1. (976 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	APC2	Uncharacterized protein. (2292 aa)
	APC	APC_basic domain-containing protein. (2713 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1. (81 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
	AXIN2	Axin-2. (843 aa)
	AXIN1	Axin 1. (867 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APC	APC2	ENSSSCP00000037698	ENSSSCP00000037191	APC_basic domain-containing protein.	Uncharacterized protein.	0.905
APC	AXIN1	ENSSSCP00000037698	ENSSSCP00000072335	APC_basic domain-containing protein.	Axin 1.	0.996
APC	AXIN2	ENSSSCP00000037698	ENSSSCP00000054961	APC_basic domain-containing protein.	Axin-2.	0.977
APC	CTNNB1	ENSSSCP00000037698	ENSSSCP00000031836	APC_basic domain-containing protein.	Catenin beta 1.	0.997
APC	CTNNBIP1	ENSSSCP00000037698	ENSSSCP00000041866	APC_basic domain-containing protein.	Beta-catenin-interacting protein 1.	0.717
APC	GSK3A	ENSSSCP00000037698	ENSSSCP00000003288	APC_basic domain-containing protein.	Protein kinase domain-containing protein.	0.628
APC	GSK3B	ENSSSCP00000037698	ENSSSCP00000046229	APC_basic domain-containing protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.994
APC	SIAH1	ENSSSCP00000037698	ENSSSCP00000035318	APC_basic domain-containing protein.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.543
APC2	APC	ENSSSCP00000037191	ENSSSCP00000037698	Uncharacterized protein.	APC_basic domain-containing protein.	0.905
APC2	AXIN1	ENSSSCP00000037191	ENSSSCP00000072335	Uncharacterized protein.	Axin 1.	0.876
APC2	AXIN2	ENSSSCP00000037191	ENSSSCP00000054961	Uncharacterized protein.	Axin-2.	0.967
APC2	CTNNB1	ENSSSCP00000037191	ENSSSCP00000031836	Uncharacterized protein.	Catenin beta 1.	0.979
APC2	CTNNBIP1	ENSSSCP00000037191	ENSSSCP00000041866	Uncharacterized protein.	Beta-catenin-interacting protein 1.	0.804
APC2	GSK3A	ENSSSCP00000037191	ENSSSCP00000003288	Uncharacterized protein.	Protein kinase domain-containing protein.	0.613
APC2	GSK3B	ENSSSCP00000037191	ENSSSCP00000046229	Uncharacterized protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.959
APC2	SIAH1	ENSSSCP00000037191	ENSSSCP00000035318	Uncharacterized protein.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.435
AXIN1	APC	ENSSSCP00000072335	ENSSSCP00000037698	Axin 1.	APC_basic domain-containing protein.	0.996
AXIN1	APC2	ENSSSCP00000072335	ENSSSCP00000037191	Axin 1.	Uncharacterized protein.	0.876
AXIN1	AXIN2	ENSSSCP00000072335	ENSSSCP00000054961	Axin 1.	Axin-2.	0.784
AXIN1	CTNNB1	ENSSSCP00000072335	ENSSSCP00000031836	Axin 1.	Catenin beta 1.	0.989