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PRSS58 PRSS58 F1SRS1_PIG F1SRS1_PIG PRSS2 PRSS2 LOC100515176 LOC100515176 LOC110259104 LOC110259104 PRSS56 PRSS56 KLKB1 KLKB1 HGF HGF CFD CFD PRTN3 PRTN3 AZU1 AZU1 F2 F2 F9 F9 MST1 MST1 PRSS50 PRSS50 F1SNW5_PIG F1SNW5_PIG PLAU PLAU F1RJP7_PIG F1RJP7_PIG F7 F7 F10 F10 PRSS12 PRSS12 PRSS48 PRSS48 TMPRSS11B TMPRSS11B TMPRSS11F TMPRSS11F LOC110261434 LOC110261434 PLAT PLAT LOC100738056 LOC100738056 TMPRSS11D TMPRSS11D PRSS33 PRSS33 PRSS27 PRSS27 LOC396700 LOC396700 PRSS36 PRSS36 KLK8 KLK8 CFB CFB MASP2 MASP2 PROC PROC I3LP35_PIG I3LP35_PIG PRSS57 PRSS57 PRSS21 PRSS21 ELANE ELANE KLK15 KLK15 HP HP ACR ACR TMPRSS11E TMPRSS11E KLK5 KLK5 KLK13 KLK13 PRSS41 PRSS41 HGFAC HGFAC TMPRSS7 TMPRSS7 TMPRSS11A TMPRSS11A LOC100154047 LOC100154047 TMPRSS4 TMPRSS4 KLK10 KLK10 LOC100739735 LOC100739735 PRSS45P PRSS45P PRSS22 PRSS22 CFI CFI LOC100302368 LOC100302368 KLK7 KLK7 TMPRSS9 TMPRSS9 PRSS51 PRSS51 A0A287AEX0_PIG A0A287AEX0_PIG KLK6 KLK6 TMPRSS12 TMPRSS12 MCT7 MCT7 F11 F11 C1RL C1RL C2 C2 LOC100739080 LOC100739080 F1SGR9_PIG F1SGR9_PIG CTRC CTRC CELA1 CELA1 PRSS8 PRSS8 CELA2A CELA2A TMPRSS15 TMPRSS15 A0A5G2QY36_PIG A0A5G2QY36_PIG LOC100513671 LOC100513671 GZMB GZMB PLG PLG HABP2 HABP2 HPN HPN TMPRSS5 TMPRSS5 MASP1 MASP1 KLK12 KLK12 TMPRSS13 TMPRSS13 F12 F12 KLK1 KLK1 CTRB2 CTRB2 LOC100621820 LOC100621820 LOC100512727 LOC100512727 PRSS37 PRSS37 OVCH2 OVCH2 I3LDA9_PIG I3LDA9_PIG CTRL CTRL PRSS46 PRSS46 KLK4 KLK4 KLK14 KLK14 GZMA-2 GZMA-2 GZMA GZMA GZMK GZMK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRSS58Serine protease 58; Belongs to the peptidase S1 family. (241 aa)
F1SRS1_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (244 aa)
PRSS2Putative trypsinogen; Belongs to the peptidase S1 family. (247 aa)
LOC100515176Peptidase S1 domain-containing protein. (162 aa)
LOC110259104Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (429 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (605 aa)
KLKB1Uncharacterized protein; Belongs to the peptidase S1 family. (643 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
CFDComplement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). (259 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (268 aa)
AZU1Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily. (246 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (462 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
PRSS50Peptidase S1 domain-containing protein. (192 aa)
F1SNW5_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (391 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa)
F1RJP7_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (293 aa)
F7Uncharacterized protein. (455 aa)
F10Uncharacterized protein. (536 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (322 aa)
TMPRSS11BTransmembrane protease serine; Belongs to the peptidase S1 family. (417 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
LOC110261434Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (270 aa)
PLATTissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa)
LOC100738056Uncharacterized protein; Belongs to the peptidase S1 family. (368 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (278 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (326 aa)
LOC396700Tryptase beta-2 preproprotein; Belongs to the peptidase S1 family. (317 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (855 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (259 aa)
CFBComplement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family. (851 aa)
MASP2Uncharacterized protein; Belongs to the peptidase S1 family. (823 aa)
PROCVitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa)
I3LP35_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (279 aa)
PRSS21Serine protease 21; Belongs to the peptidase S1 family. (317 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (260 aa)
HPHaptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] (354 aa)
ACRAcrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family. (414 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (422 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (295 aa)
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (278 aa)
PRSS41Serine protease 41; Belongs to the peptidase S1 family. (314 aa)
HGFACHGF activator. (661 aa)
TMPRSS7Transmembrane serine protease 7; Belongs to the peptidase S1 family. (829 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (420 aa)
LOC100154047Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (353 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)
KLK10Kallikrein related peptidase 10; Belongs to the peptidase S1 family. (278 aa)
LOC100739735Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (290 aa)
PRSS45PSerine protease 45, pseudogene; Belongs to the peptidase S1 family. (318 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (338 aa)
CFIComplement factor I isoform 1 preproprotein; Belongs to the peptidase S1 family. (587 aa)
LOC100302368Trypsin. (246 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (257 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1074 aa)
PRSS51Serine protease 51; Belongs to the peptidase S1 family. (266 aa)
A0A287AEX0_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (228 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (246 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (366 aa)
MCT7Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. (275 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (588 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (853 aa)
LOC100739080Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (237 aa)
F1SGR9_PIGPeptidase S1 domain-containing protein. (236 aa)
CTRCChymotrypsin-C; Belongs to the peptidase S1 family. (268 aa)
CELA1Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (257 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (344 aa)
CELA2AChymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (287 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1049 aa)
A0A5G2QY36_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (331 aa)
LOC100513671Transmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
GZMBPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
HABP2Hyaluronan binding protein 2. (591 aa)
HPNHepsin; Belongs to the peptidase S1 family. (449 aa)
TMPRSS5Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (198 aa)
MASP1Mannan-binding lectin serine protease 1 isoform 2; Belongs to the peptidase S1 family. (728 aa)
KLK12Kallikrein related peptidase 12; Belongs to the peptidase S1 family. (248 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (526 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa)
KLK1Glandular kallikrein; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (263 aa)
CTRB2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
LOC100621820Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
LOC100512727Transmembrane protease serine; Belongs to the peptidase S1 family. (407 aa)
PRSS37Putative inactive serine protease 37. (235 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (566 aa)
I3LDA9_PIGPeptidase S1 domain-containing protein. (236 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
PRSS46Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (312 aa)
KLK4Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family. (254 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (252 aa)
GZMA-2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (258 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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