(8 nodes) Toll-like receptor network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (855 aa)
	TLR2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
	CHADL	Chondroadherin like. (760 aa)
	TLR10	TIR domain-containing protein; Belongs to the Toll-like receptor family. (810 aa)
	TLR1	Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
	TLR6	Toll-like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
	TLR3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TLR1	TLR10	ENSSSCP00000024245	ENSSSCP00000025971	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.444
TLR1	TLR2	ENSSSCP00000024245	ENSSSCP00000067954	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Belongs to the Toll-like receptor family.	0.998
TLR1	TLR3	ENSSSCP00000024245	ENSSSCP00000016745	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.580
TLR1	TLR4	ENSSSCP00000024245	ENSSSCP00000060828	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.576
TLR1	TLR5	ENSSSCP00000024245	ENSSSCP00000061007	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.489
TLR1	TLR6	ENSSSCP00000024245	ENSSSCP00000021244	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.976
TLR10	TLR1	ENSSSCP00000025971	ENSSSCP00000024245	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.444
TLR10	TLR2	ENSSSCP00000025971	ENSSSCP00000067954	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Belongs to the Toll-like receptor family.	0.733
TLR10	TLR3	ENSSSCP00000025971	ENSSSCP00000016745	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.422
TLR10	TLR4	ENSSSCP00000025971	ENSSSCP00000060828	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.447
TLR10	TLR5	ENSSSCP00000025971	ENSSSCP00000061007	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.462
TLR10	TLR6	ENSSSCP00000025971	ENSSSCP00000021244	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.501
TLR2	TLR1	ENSSSCP00000067954	ENSSSCP00000024245	Toll-like receptor 2; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.998
TLR2	TLR10	ENSSSCP00000067954	ENSSSCP00000025971	Toll-like receptor 2; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.733
TLR2	TLR3	ENSSSCP00000067954	ENSSSCP00000016745	Toll-like receptor 2; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.665
TLR2	TLR4	ENSSSCP00000067954	ENSSSCP00000060828	Toll-like receptor 2; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.985
TLR2	TLR5	ENSSSCP00000067954	ENSSSCP00000061007	Toll-like receptor 2; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.951
TLR2	TLR6	ENSSSCP00000067954	ENSSSCP00000021244	Toll-like receptor 2; Belongs to the Toll-like receptor family.	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.999
TLR3	TLR1	ENSSSCP00000016745	ENSSSCP00000024245	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.580
TLR3	TLR10	ENSSSCP00000016745	ENSSSCP00000025971	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.422