(9 nodes) Cysteine peptidase, asparagine active site network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	CTSH	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa)
	CTSW	Cathepsin W; Belongs to the peptidase C1 family. (368 aa)
	CTSB	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
	TINAG	Tubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (476 aa)
	CTSC	Cathepsin C; Belongs to the peptidase C1 family. (463 aa)
	CTSV	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
	CTSL	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family. (332 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (304 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (341 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSB	CTSH	ENSSSCP00000024395	ENSSSCP00000001934	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	0.542
CTSB	CTSL	ENSSSCP00000024395	ENSSSCP00000011675	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	0.581
CTSB	CTSS	ENSSSCP00000024395	ENSSSCP00000007089	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	Cathepsin S; Belongs to the peptidase C1 family.	0.785
CTSB	CTSV	ENSSSCP00000024395	ENSSSCP00000011919	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.575
CTSB	CTSZ	ENSSSCP00000024395	ENSSSCP00000008030	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	Cathepsin Z; Belongs to the peptidase C1 family.	0.517
CTSC	CTSL	ENSSSCP00000015844	ENSSSCP00000011675	Cathepsin C; Belongs to the peptidase C1 family.	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	0.408
CTSC	CTSS	ENSSSCP00000015844	ENSSSCP00000007089	Cathepsin C; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.461
CTSC	CTSV	ENSSSCP00000015844	ENSSSCP00000011919	Cathepsin C; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.407
CTSC	CTSZ	ENSSSCP00000015844	ENSSSCP00000008030	Cathepsin C; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.626
CTSH	CTSB	ENSSSCP00000001934	ENSSSCP00000024395	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	0.542
CTSH	CTSL	ENSSSCP00000001934	ENSSSCP00000011675	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	0.407
CTSH	CTSS	ENSSSCP00000001934	ENSSSCP00000007089	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.420
CTSH	CTSV	ENSSSCP00000001934	ENSSSCP00000011919	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.440
CTSH	CTSZ	ENSSSCP00000001934	ENSSSCP00000008030	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.468
CTSL	CTSB	ENSSSCP00000011675	ENSSSCP00000024395	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	0.581
CTSL	CTSC	ENSSSCP00000011675	ENSSSCP00000015844	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.408
CTSL	CTSH	ENSSSCP00000011675	ENSSSCP00000001934	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	0.407
CTSL	CTSS	ENSSSCP00000011675	ENSSSCP00000007089	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.941
CTSL	CTSV	ENSSSCP00000011675	ENSSSCP00000011919	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.901
CTSS	CTSB	ENSSSCP00000007089	ENSSSCP00000024395	Cathepsin S; Belongs to the peptidase C1 family.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).	0.785