(39 nodes) (2021) Comprehensive Transcriptomic Analysis Identifies Novel Antiviral Factors Against Influenza A Virus Infection. network (Sus scrofa)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IFITM1	Uncharacterized protein. (147 aa)
	IFNB1	Interferon-beta-1. (186 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (713 aa)
	OASL	2'-5'-oligoadenylate synthase-like protein isoform a. (348 aa)
	IFIT1	Interferon-stimulated protein 60. (509 aa)
	STAT3	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
	DHX58	DExH-box helicase 58. (681 aa)
	CCL11	C-C motif chemokine. (97 aa)
	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5. (968 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (189 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	HESX1	HESX homeobox 1. (185 aa)
	BATF2	Basic leucine zipper transcriptional factor ATF-like 2 isoform 1. (276 aa)
	IFIT2	Interferon induced protein with tetratricopeptide repeats 2. (473 aa)
	CXCL10	C-X-C motif chemokine. (104 aa)
	CCL8	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
	DUSP2	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (311 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	IFI44	G domain-containing protein. (438 aa)
	ZC3HAV1	Zinc finger CCCH-type antiviral protein 1 isoform 1. (894 aa)
	GBP1	GB1/RHD3-type G domain-containing protein. (614 aa)
	IL29	Interferon lambda-1. (191 aa)
	ISG15	Ubiquitin-like modifier. (167 aa)
	HAMP	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1023 aa)
	DDX58	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
	IER5L	Immediate early response 5 like. (403 aa)
	IFI6	Interferon alpha inducible protein 6. (171 aa)
	SHFL	Uncharacterized protein. (286 aa)
	USP18	USP domain-containing protein; Belongs to the peptidase C19 family. (376 aa)
	RSAD2	Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)
	MX2	Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
	FERMT3	Fermitin family member 3. (667 aa)
	FOLR2	Folate receptor beta. (319 aa)
	CXCL11	C-X-C motif chemokine. (129 aa)
	CMPK2	Cytidine/uridine monophosphate kinase 2. (449 aa)
	IFITM3	Uncharacterized protein. (206 aa)
	OAS1	2'-5'-oligoadenylate synthase 1. (334 aa)
	IL17A	Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF2	CMPK2	ENSSSCP00000027956	ENSSSCP00000073978	Basic leucine zipper transcriptional factor ATF-like 2 isoform 1.	Cytidine/uridine monophosphate kinase 2.	0.476
BATF2	GBP1	ENSSSCP00000027956	ENSSSCP00000038500	Basic leucine zipper transcriptional factor ATF-like 2 isoform 1.	GB1/RHD3-type G domain-containing protein.	0.415
BATF2	IFI6	ENSSSCP00000027956	ENSSSCP00000048654	Basic leucine zipper transcriptional factor ATF-like 2 isoform 1.	Interferon alpha inducible protein 6.	0.408
BATF2	SHFL	ENSSSCP00000027956	ENSSSCP00000050582	Basic leucine zipper transcriptional factor ATF-like 2 isoform 1.	Uncharacterized protein.	0.497
CCL11	CCL8	ENSSSCP00000018778	ENSSSCP00000032773	C-C motif chemokine.	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	0.458
CCL11	CXCL10	ENSSSCP00000018778	ENSSSCP00000032297	C-C motif chemokine.	C-X-C motif chemokine.	0.973
CCL11	CXCL11	ENSSSCP00000018778	ENSSSCP00000074141	C-C motif chemokine.	C-X-C motif chemokine.	0.650
CCL11	IFNG	ENSSSCP00000018778	ENSSSCP00000036242	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.828
CCL11	IL17A	ENSSSCP00000018778	ENSSSCP00000001905	C-C motif chemokine.	Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family.	0.679
CCL11	IL6	ENSSSCP00000018778	ENSSSCP00000023819	C-C motif chemokine.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.720
CCL8	CCL11	ENSSSCP00000032773	ENSSSCP00000018778	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	C-C motif chemokine.	0.458
CCL8	CXCL10	ENSSSCP00000032773	ENSSSCP00000032297	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	C-X-C motif chemokine.	0.922
CCL8	CXCL11	ENSSSCP00000032773	ENSSSCP00000074141	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	C-X-C motif chemokine.	0.591
CCL8	IFIT1	ENSSSCP00000032773	ENSSSCP00000011141	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Interferon-stimulated protein 60.	0.401
CCL8	IFNG	ENSSSCP00000032773	ENSSSCP00000036242	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.658
CCL8	IL17A	ENSSSCP00000032773	ENSSSCP00000001905	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family.	0.412
CCL8	IL6	ENSSSCP00000032773	ENSSSCP00000023819	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.592
CCL8	ISG15	ENSSSCP00000032773	ENSSSCP00000041015	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Ubiquitin-like modifier.	0.500
CCL8	MX2	ENSSSCP00000032773	ENSSSCP00000055951	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.664
CCL8	SHFL	ENSSSCP00000032773	ENSSSCP00000050582	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Uncharacterized protein.	0.402