STRINGSTRING
TRDN TRDN EPHA4 EPHA4 ANKH ANKH ARG1 ARG1 HPCAL1 HPCAL1 S100A8 S100A8 FGFR2 FGFR2 BMP5 BMP5 USP34 USP34 SLCO3A1 SLCO3A1 TNC TNC MMP9 MMP9 CXCL2 CXCL2 CLU CLU GADD45A GADD45A VAV3 VAV3 TLR2 TLR2 TIMP1 TIMP1 CRYBG1 CRYBG1 IGF1 IGF1 TYRO3 TYRO3 THBS1 THBS1 CTSS CTSS SPP1 SPP1 PLAU PLAU ITIH5 ITIH5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRDNTriadin. (729 aa)
EPHA4EPH receptor A4. (986 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (494 aa)
ARG1Arginase-1. (337 aa)
HPCAL1Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (212 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3522 aa)
SLCO3A1Solute carrier organic anion transporter family member. (692 aa)
TNCTenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Belongs to the tenascin family. (2420 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (184 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
CRYBG1Beta/gamma crystallin domain-containing protein 1 isoform X1; Belongs to the beta/gamma-crystallin family. (2095 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
TYRO3TYRO3 protein tyrosine kinase. (913 aa)
THBS1Uncharacterized protein. (1170 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain 5. (944 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (28%) [HD]