| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALAD | CPOX | ENSBTAP00000000315 | ENSBTAP00000005398 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Coproporphyrinogen oxidase. | 0.908 |
| ALAD | FECH | ENSBTAP00000000315 | ENSBTAP00000008384 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.890 |
| ALAD | HMBS | ENSBTAP00000000315 | ENSBTAP00000007052 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
| ALAD | PPOX | ENSBTAP00000000315 | ENSBTAP00000053328 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.909 |
| ALAD | UROD | ENSBTAP00000000315 | ENSBTAP00000059516 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.951 |
| ALAD | UROS | ENSBTAP00000000315 | ENSBTAP00000007615 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen III synthase. | 0.996 |
| CPOX | ALAD | ENSBTAP00000005398 | ENSBTAP00000000315 | Coproporphyrinogen oxidase. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.908 |
| CPOX | FECH | ENSBTAP00000005398 | ENSBTAP00000008384 | Coproporphyrinogen oxidase. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.956 |
| CPOX | HMBS | ENSBTAP00000005398 | ENSBTAP00000007052 | Coproporphyrinogen oxidase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.851 |
| CPOX | PPOX | ENSBTAP00000005398 | ENSBTAP00000053328 | Coproporphyrinogen oxidase. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.998 |
| CPOX | UROD | ENSBTAP00000005398 | ENSBTAP00000059516 | Coproporphyrinogen oxidase. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.998 |
| CPOX | UROS | ENSBTAP00000005398 | ENSBTAP00000007615 | Coproporphyrinogen oxidase. | Uroporphyrinogen III synthase. | 0.926 |
| FECH | ALAD | ENSBTAP00000008384 | ENSBTAP00000000315 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.890 |
| FECH | CPOX | ENSBTAP00000008384 | ENSBTAP00000005398 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Coproporphyrinogen oxidase. | 0.956 |
| FECH | HMBS | ENSBTAP00000008384 | ENSBTAP00000007052 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.894 |
| FECH | PPOX | ENSBTAP00000008384 | ENSBTAP00000053328 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.999 |
| FECH | UROD | ENSBTAP00000008384 | ENSBTAP00000059516 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.981 |
| FECH | UROS | ENSBTAP00000008384 | ENSBTAP00000007615 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Uroporphyrinogen III synthase. | 0.895 |
| HMBS | ALAD | ENSBTAP00000007052 | ENSBTAP00000000315 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.999 |
| HMBS | CPOX | ENSBTAP00000007052 | ENSBTAP00000005398 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | Coproporphyrinogen oxidase. | 0.851 |