STRINGSTRING
INPP5E INPP5E LZTFL1 LZTFL1 TMEM107 TMEM107 ARL3 ARL3 TTC21B TTC21B RPGRIP1 RPGRIP1 BBS7 BBS7 ARL13B ARL13B NPHP3 NPHP3 IFT57 IFT57 BBS9 BBS9 HSPB11 HSPB11 TCTN2 TCTN2 UNC119B UNC119B BBS12 BBS12 BBS4 BBS4 NPHP1 NPHP1 IFT20 IFT20 ARL6 ARL6 BBS5 BBS5 TCTN3 TCTN3 IFT43 IFT43 IFT46 IFT46 IQCB1 IQCB1 UNC119 UNC119 TTC30B TTC30B WDR19 WDR19 CCDC28B CCDC28B TULP3 TULP3 SDCCAG8 SDCCAG8 IFT172 IFT172 CEP290 CEP290 IFT74 IFT74 BBS1 BBS1 TMEM216 TMEM216 B9D2 B9D2 BBS2 BBS2 IFT122 IFT122 IFT27 IFT27 TTC30A TTC30A TTC8 TTC8 TTC26 TTC26 IFT80 IFT80 NPHP4 NPHP4 IFT140 IFT140 TTC21A TTC21A TRAF3IP1 TRAF3IP1 RP2 RP2 MKS1 MKS1 C2CD6 C2CD6 TMEM67 TMEM67 CC2D2A CC2D2A G5E6L5_BOVIN G5E6L5_BOVIN TCTN1 TCTN1 BBIP1 BBIP1 IFT81 IFT81 IFT52 IFT52 PDE6D PDE6D TMEM237 TMEM237 WDR35 WDR35 CLUAP1 CLUAP1 RPGRIP1L RPGRIP1L TMEM231 TMEM231 IFT22 IFT22 IFT22-2 IFT22-2 RPGR RPGR ENSBTAP00000066185 ENSBTAP00000066185 B9D1 B9D1 GPR161 GPR161 ENSBTAP00000072807 ENSBTAP00000072807 BBS10 BBS10 IFT88 IFT88 AHI1 AHI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INPP5EInositol polyphosphate-5-phosphatase E. (656 aa)
LZTFL1Leucine zipper transcription factor-like protein 1; Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity). (299 aa)
TMEM107Transmembrane protein 107. (140 aa)
ARL3ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] (198 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
RPGRIP1X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells; Belongs to the RPGRIP1 family. (1213 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
NPHP3Nephrocystin 3. (1331 aa)
IFT57Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity). (429 aa)
BBS9Uncharacterized protein. (887 aa)
HSPB11Heat shock protein family B (small) member 11. (143 aa)
TCTN2Tectonic family member 2. (665 aa)
UNC119BUnc-119 lipid binding chaperone B. (254 aa)
BBS12BBS12 protein. (708 aa)
BBS4Bardet-Biedl syndrome 4 protein homolog; May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the [...] (519 aa)
NPHP1Nephrocystin 1. (686 aa)
IFT20Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly sperm [...] (156 aa)
ARL6ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper r [...] (186 aa)
BBS5Bardet-Biedl syndrome 5 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] (341 aa)
TCTN3Tectonic family member 3. (599 aa)
IFT43Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. (207 aa)
IFT46Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). (301 aa)
IQCB1IQ motif containing B1. (598 aa)
UNC119Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...] (240 aa)
TTC30BTetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
WDR19WD repeat domain 19. (1342 aa)
CCDC28BCoiled-coil domain containing 28B. (246 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (478 aa)
SDCCAG8Uncharacterized protein. (715 aa)
IFT172Intraflagellar transport 172. (421 aa)
CEP290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] (1453 aa)
IFT74Intraflagellar transport 74. (600 aa)
BBS1BBS1 domain-containing protein. (667 aa)
TMEM216Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. (141 aa)
B9D2B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. (175 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
IFT122Intraflagellar transport 122. (1182 aa)
IFT27Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a rol [...] (186 aa)
TTC30ATetratricopeptide repeat protein 30A; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
TTC8Tetratricopeptide repeat domain 8. (501 aa)
TTC26Tetratricopeptide repeat domain 26. (554 aa)
IFT80Intraflagellar transport 80. (760 aa)
NPHP4Nephrocystin 4. (1430 aa)
IFT140Intraflagellar transport 140. (1457 aa)
TTC21ATetratricopeptide repeat domain 21A. (724 aa)
TRAF3IP1TRAF3 interacting protein 1. (686 aa)
RP2Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (350 aa)
MKS1MKS transition zone complex subunit 1. (558 aa)
C2CD6C2 calcium dependent domain containing 6. (1847 aa)
TMEM67Uncharacterized protein. (996 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
G5E6L5_BOVINUncharacterized protein. (807 aa)
TCTN1Tectonic family member 1. (588 aa)
BBIP1Uncharacterized protein. (69 aa)
IFT81Intraflagellar transport 81. (698 aa)
IFT52Intraflagellar transport 52 homolog (Chlamydomonas). (440 aa)
PDE6DRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. [...] (160 aa)
TMEM237Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity); Belongs to the TMEM237 family. (434 aa)
WDR35WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. (1238 aa)
CLUAP1Clusterin associated protein 1. (457 aa)
RPGRIP1LRPGRIP1 like. (1270 aa)
TMEM231Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (348 aa)
IFT22Intraflagellar transport protein 22 homolog. (199 aa)
IFT22-2Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B; Belongs to the small GTPase superfamily. Rab family. (217 aa)
RPGRUncharacterized protein. (732 aa)
ENSBTAP00000066185Uncharacterized protein. (237 aa)
B9D1B9 domain containing 1. (239 aa)
GPR161G protein-coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signalin [...] (573 aa)
ENSBTAP00000072807Uncharacterized protein. (166 aa)
BBS10Bardet-Biedl syndrome 10. (721 aa)
IFT88Intraflagellar transport 88. (850 aa)
AHI1Abelson helper integration site 1. (1172 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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