STRINGSTRING
PRDM1 PRDM1 IRF4 IRF4 CLEC9A CLEC9A BATF2 BATF2 ZBTB46 ZBTB46 IRF8 IRF8 AICDA AICDA SPI1 SPI1 BATF BATF EBF1 EBF1 SPIB SPIB BATF3 BATF3 BCL6 BCL6 LOC618409 LOC618409 PAX5 PAX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRDM1PR/SET domain 1. (828 aa)
IRF4Interferon regulatory factor 4. (451 aa)
CLEC9AC-type lectin domain containing 9A. (241 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (275 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
IRF8Interferon regulatory factor 8. (427 aa)
AICDASingle-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. (199 aa)
SPI1Spi-1 proto-oncogene. (293 aa)
BATFBasic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'- TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'- TGAnTCA/G [...] (125 aa)
EBF1EBF transcription factor 1. (591 aa)
SPIBETS domain-containing protein. (261 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (151 aa)
BCL6BCL6 transcription repressor. (706 aa)
LOC618409IRF tryptophan pentad repeat domain-containing protein. (494 aa)
PAX5Paired box 5. (392 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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