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| | MYO18B | Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2509 aa) |
| | MYH3 | Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa) |
| | CKMT2 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (419 aa) |
| | MEF2B | Myocyte enhancer factor 2B. (368 aa) |
| | MYL7 | Myosin light chain 7. (175 aa) |
| | LMOD2 | LMOD2 protein. (553 aa) |
| | MYOD1 | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (318 aa) |
| | TNNI3 | Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity); Belongs to the DNAAF3 family. (677 aa) |
| | MYOZ2 | Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). (264 aa) |
| | MYH14 | Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2032 aa) |
| | TFG | TFG protein. (401 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa) |
| | ACTA1 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa) |
| | GATM | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). (423 aa) |
| | MYH6 | Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa) |
| | MYOG | Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (224 aa) |
| | MYH1 | Myosin-1; Muscle contraction. (1938 aa) |
| | TAGLN | Transgelin; Actin cross-linking/gelling protein. (201 aa) |
| | NRBP2 | Nuclear receptor binding protein 2. (499 aa) |
| | MYOM2 | Myomesin 2. (1495 aa) |
| | MYH2 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1940 aa) |
| | TPM3 | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. (284 aa) |
| | MYOCD | Myocardin. (982 aa) |
| | MYH9 | Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1965 aa) |
| | MYL6 | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (151 aa) |
| | TNNI2 | Troponin I2, fast skeletal type. (178 aa) |
| | CNN1 | Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). (297 aa) |
| | TCAP | Telethonin; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity). (166 aa) |
| | SRF | Serum response factor. (509 aa) |
| | ID3 | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] (119 aa) |
| | MYLK3 | Myosin light chain kinase 3. (786 aa) |
| | PAX7 | Paired box 7. (505 aa) |
| | ACTG2 | Actin, gamma-enteric smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa) |
| | MYL12A | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa) |
| | ID1 | Inhibitor of DNA binding 1, HLH protein. (154 aa) |
| | FBXO32 | F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). (355 aa) |
| | MYO18A | Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (953 aa) |
| | MYPN | Myopalladin. (1320 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa) |
| | CNN2 | Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). (309 aa) |
| | ID2 | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa) |
| | LMOD1 | LMOD1 protein. (578 aa) |
| | ACTN3 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. (901 aa) |
| | CSRP3 | Cysteine and glycine-rich protein 3; Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. I [...] (194 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (473 aa) |
| | MYOZ3 | Myozenin 3. (245 aa) |
| | MYH13 | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa) |
| | TCF12 | Transcription factor 12. (570 aa) |
| | GOLPH3 | Golgi phosphoprotein 3 (Coat-protein). (298 aa) |
| | ACTA2 | Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa) |
| | MYL12B | Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. (171 aa) |
| | TRIM63 | Tripartite motif containing 63. (354 aa) |
| | MYF5 | Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (255 aa) |
| | MYBPC1 | Myosin binding protein C, slow type. (1198 aa) |
| | MYL6B | Myosin, light chain 6B, alkali, smooth muscle and non-muscle. (211 aa) |
| | TPM2 | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization; Belongs to the tropomyosin family. (284 aa) |
| | RBM20 | RNA binding motif protein 20. (1210 aa) |
| | TMOD4 | Tropomodulin-4; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). (345 aa) |
| | CKB | Creatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity); Belongs to the ATP:guanido phosphotransferase family. (381 aa) |
| | MYL1 | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (192 aa) |
| | MYL4 | Myosin, light chain 4, alkali; atrial, embryonic. (193 aa) |
| | MYOZ1 | Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). (343 aa) |
| | MYH7 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa) |
| | MYH4 | Myosin heavy chain 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa) |
| | NEBL | Nebulette. (1013 aa) |
| | TNNT3 | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (397 aa) |
| | XIRP1 | Xin actin binding repeat containing 1. (1820 aa) |
| | TNNI1 | Troponin I1, slow skeletal type. (187 aa) |
| | TNNC2 | Troponin C2, fast skeletal type. (162 aa) |
| | TNNC1 | Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa) |
| | TNNT2 | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (285 aa) |
| | ENSBTAP00000057044 | Uncharacterized protein; Belongs to the tropomyosin family. (248 aa) |
| | ENSBTAP00000057154 | Uncharacterized protein. (109 aa) |
| | TCF3 | Transcription factor 3. (642 aa) |
| | MYOT | Myotilin. (605 aa) |
| | MYH15 | Myosin heavy chain 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1965 aa) |
| | MYL10 | Myosin light chain 10. (283 aa) |
| | ENSBTAP00000058557 | Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (329 aa) |
| | CALD1 | Non-muscle caldesmon; Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cell [...] (556 aa) |
| | SMTN | Smoothelin. (912 aa) |
| | ENSBTAP00000059410 | Uncharacterized protein. (514 aa) |
| | MYLK | Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] (1176 aa) |
| | CKM | Creatine kinase M-type; Belongs to the ATP:guanido phosphotransferase family. (388 aa) |
| | ENSBTAP00000060355 | Uncharacterized protein. (62 aa) |
| | TCF4 | Transcription factor 4. (667 aa) |
| | MYH8 | Myosin heavy chain 8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa) |
| | MYBPC2 | Myosin binding protein C, fast type. (1167 aa) |
| | MYL9 | Myosin regulatory light polypeptide 9. (172 aa) |
| | MYLK4 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa) |
| | TPM1 | Tropomyosin alpha-1 chain; Belongs to the tropomyosin family. (457 aa) |
| | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). (623 aa) |
| | NRAP | Nebulin related anchoring protein. (1740 aa) |
| | ACTN2 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. (897 aa) |
| | MYBPC3 | Myosin binding protein C, cardiac. (1277 aa) |
| | MYOM3 | Myomesin 3. (1430 aa) |
| | ACTC1 | Actin, alpha cardiac muscle 1. (392 aa) |
| | MYLPF | Myosin regulatory light chain 2, skeletal muscle isoform. (170 aa) |
| | MYH10 | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). (1976 aa) |
| | TTN | Uncharacterized protein. (563 aa) |
| | MYF6 | Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (422 aa) |
| | MYL2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (181 aa) |
| | NEB | Nebulin. (8139 aa) |
| | MYH11 | Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1972 aa) |
| | SORBS3 | Sorbin and SH3 domain containing 3. (866 aa) |
| | MYL3 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. (262 aa) |
| | ENSBTAP00000067612 | PDZ domain-containing protein. (398 aa) |
| | ENSBTAP00000068261 | Uncharacterized protein. (66 aa) |
| | ENSBTAP00000068440 | Uncharacterized protein. (202 aa) |
| | ENSBTAP00000070639 | Uncharacterized protein. (442 aa) |
| | ENSBTAP00000070988 | Uncharacterized protein. (79 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (795 aa) |
| | ENSBTAP00000071354 | Uncharacterized protein. (82 aa) |
| | ENSBTAP00000071723 | Uncharacterized protein. (622 aa) |
| | ID4 | Inhibitor of DNA binding 4, HLH protein. (164 aa) |
| | MYH7B | Myosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa) |
| | TNNT1 | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (281 aa) |
| | MEF2A | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (498 aa) |
| | SORBS1 | Sorbin and SH3 domain containing 1. (922 aa) |
| | ENSBTAP00000074423 | Uncharacterized protein. (551 aa) |
| | MEF2D | Myocyte enhancer factor 2D. (513 aa) |
