STRINGSTRING
KRT1 KRT1 KRT6A KRT6A KRT85 KRT85 KRT78 KRT78 EPHA2 EPHA2 KRT8 KRT8 SAV1 SAV1 IRF6 IRF6 WNT16 WNT16 STK4 STK4 MAFB MAFB ABCA12 ABCA12 TGM1 TGM1 YAP1 YAP1 KRT83 KRT83 KRT17 KRT17 KRT82 KRT82 KRT72 KRT72 KRT73 KRT73 ACER1 ACER1 EXPH5 EXPH5 SFN SFN TMEM79 TMEM79 DNASE1L2 DNASE1L2 CSTA CSTA ASAH1 ASAH1 CYP26B1 CYP26B1 KRT4 KRT4 KRT79 KRT79 INTU INTU KRT10 KRT10 NOTCH1 NOTCH1 TSG101 TSG101 KRT86 KRT86 LATS2 LATS2 KEL KEL LATS1 LATS1 DSP DSP TP63 TP63 CASP3 CASP3 ANXA1 ANXA1 KRT5 KRT5 KRT7 KRT7 KRT84 KRT84 BCL11B BCL11B IFT74 IFT74 ST14 ST14 TXNIP TXNIP WNT5A WNT5A CASP14 CASP14 FOSL2 FOSL2 KRT75 KRT75 KRT71 KRT71 LOC507184 LOC507184 KRT81 KRT81 KRT89 KRT89 UGCG UGCG CNFN CNFN CDH3 CDH3 SCEL SCEL KRT6B KRT6B KRT16 KRT16 MAP2K1 MAP2K1 DSG4 DSG4 SHARPIN SHARPIN CLIC4 CLIC4 KRT6C KRT6C CERS3 CERS3 MED1 MED1 POU3F1 POU3F1 PLEC PLEC LCE3C LCE3C EZH2 EZH2 FOXN1 FOXN1 LOC112446984 LOC112446984 LOC112446672 LOC112446672 PPP3CA PPP3CA ENSBTAP00000068337 ENSBTAP00000068337 KRT77 KRT77 LCE1B LCE1B PNPLA1 PNPLA1 BCR BCR KRT80 KRT80 LOC618359 LOC618359 PAX6 PAX6 LOC787600 LOC787600 ADAM9 ADAM9 ENSBTAP00000063115 ENSBTAP00000063115 ENSBTAP00000062188 ENSBTAP00000062188 LOC112446673 LOC112446673 KRT3 KRT3 PALLD PALLD KDF1 KDF1 TGM3 TGM3 KRT76 KRT76 KRT2 KRT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT1Keratin 1; Belongs to the intermediate filament family. (606 aa)
KRT6AIF rod domain-containing protein; Belongs to the intermediate filament family. (571 aa)
KRT85Keratin 85; Belongs to the intermediate filament family. (507 aa)
KRT78Keratin, type II cytoskeletal 78; Belongs to the intermediate filament family. (528 aa)
EPHA2EPH receptor A2. (975 aa)
KRT8Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Belongs to the intermediate filament family. (478 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
IRF6Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family. (466 aa)
WNT16Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (362 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
ABCA12ATP binding cassette subfamily A member 12. (2596 aa)
TGM1Transglutaminase 1. (846 aa)
YAP1Yes associated protein 1. (432 aa)
KRT83Keratin, type II cuticular Hb3; Belongs to the intermediate filament family. (509 aa)
KRT17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (441 aa)
KRT82KRT82 protein; Belongs to the intermediate filament family. (514 aa)
KRT72Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). (524 aa)
KRT73Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). (540 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
EXPH5Exophilin 5. (1933 aa)
SFN14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). (248 aa)
TMEM79Transmembrane protein 79; Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). (395 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
CSTACystatin-A; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (98 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (395 aa)
CYP26B1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] (512 aa)
KRT4KRT4 protein; Belongs to the intermediate filament family. (549 aa)
KRT79Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family. (530 aa)
INTUProtein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity ef [...] (933 aa)
KRT10Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (526 aa)
NOTCH1Notch receptor 1. (2533 aa)
TSG101Tumor susceptibility 101. (391 aa)
KRT86IF rod domain-containing protein; Belongs to the intermediate filament family. (486 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
KELKell metallo-endopeptidase. (721 aa)
LATS1Large tumor suppressor kinase 1. (1123 aa)
DSPDesmoplakin. (2889 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (275 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
KRT5Keratin, type II cytoskeletal 5. (597 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells; Belongs to the intermediate filament family. (466 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (593 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (904 aa)
IFT74Intraflagellar transport 74. (600 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity); Belongs to the peptidase S1 family. (855 aa)
TXNIPThioredoxin interacting protein. (391 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CASP14Caspase 14; Belongs to the peptidase C14A family. (246 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
KRT75Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). (543 aa)
KRT71Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). (550 aa)
LOC507184IF rod domain-containing protein; Belongs to the intermediate filament family. (474 aa)
KRT81Keratin, type II cuticular Hb1; Belongs to the intermediate filament family. (500 aa)
KRT89KRT85 protein; Belongs to the intermediate filament family. (493 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
CNFNCornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (124 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (829 aa)
SCELSCEL protein. (697 aa)
KRT6BIF rod domain-containing protein; Belongs to the intermediate filament family. (571 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (465 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DSG4Desmoglein 4. (1041 aa)
SHARPINSharpin; Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BI [...] (409 aa)
CLIC4Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels. (253 aa)
KRT6CIF rod domain-containing protein; Belongs to the intermediate filament family. (571 aa)
CERS3Ceramide synthase 3. (387 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
POU3F1POU domain protein. (451 aa)
PLECPlectin. (4712 aa)
LCE3CUncharacterized protein. (87 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
FOXN1Forkhead box N1. (644 aa)
LOC112446984Uncharacterized protein. (75 aa)
LOC112446672Keratin, type II cuticular Hb1-like. (480 aa)
PPP3CASerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to t [...] (527 aa)
ENSBTAP00000068337Uncharacterized protein. (111 aa)
KRT77Keratin 77; Belongs to the intermediate filament family. (593 aa)
LCE1BUncharacterized protein. (111 aa)
PNPLA1Patatin like phospholipase domain containing 1. (568 aa)
BCRBCR activator of RhoGEF and GTPase. (1073 aa)
KRT80Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (563 aa)
LOC618359Uncharacterized protein. (84 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
LOC787600Keratin, type II cuticular Hb1. (480 aa)
ADAM9ADAM metallopeptidase domain 9. (821 aa)
ENSBTAP00000063115Uncharacterized protein. (111 aa)
ENSBTAP00000062188Uncharacterized protein. (111 aa)
LOC112446673IF rod domain-containing protein; Belongs to the intermediate filament family. (480 aa)
KRT3Keratin 3; Belongs to the intermediate filament family. (628 aa)
PALLDPalladin, cytoskeletal associated protein. (1302 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
TGM3Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 o [...] (693 aa)
KRT76Keratin, type II cytoskeletal 68 kDa, component IA; Belongs to the intermediate filament family. (612 aa)
KRT2Keratin, type II cytoskeletal 68 kDa, component IB; Belongs to the intermediate filament family. (619 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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