| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | DMRT1 | ENSBTAP00000030053 | ENSBTAP00000023667 | Androgen receptor. | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | 0.431 |
| AR | FGF9 | ENSBTAP00000030053 | ENSBTAP00000055492 | Androgen receptor. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.409 |
| AR | NR0B1 | ENSBTAP00000030053 | ENSBTAP00000020641 | Androgen receptor. | Nuclear receptor subfamily 0 group B member 1. | 0.433 |
| AR | SOX9 | ENSBTAP00000030053 | ENSBTAP00000073259 | Androgen receptor. | SRY-box transcription factor 9. | 0.545 |
| DHH | DMRT1 | ENSBTAP00000000135 | ENSBTAP00000023667 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | 0.495 |
| DHH | FGF9 | ENSBTAP00000000135 | ENSBTAP00000055492 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.576 |
| DHH | NR5A1 | ENSBTAP00000000135 | ENSBTAP00000011869 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipi [...] | 0.628 |
| DHH | SOX9 | ENSBTAP00000000135 | ENSBTAP00000073259 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | SRY-box transcription factor 9. | 0.593 |
| DMRT1 | AR | ENSBTAP00000023667 | ENSBTAP00000030053 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Androgen receptor. | 0.431 |
| DMRT1 | DHH | ENSBTAP00000023667 | ENSBTAP00000000135 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.495 |
| DMRT1 | FGF9 | ENSBTAP00000023667 | ENSBTAP00000055492 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.546 |
| DMRT1 | NR0B1 | ENSBTAP00000023667 | ENSBTAP00000020641 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Nuclear receptor subfamily 0 group B member 1. | 0.561 |
| DMRT1 | NR5A1 | ENSBTAP00000023667 | ENSBTAP00000011869 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipi [...] | 0.675 |
| DMRT1 | SOX9 | ENSBTAP00000023667 | ENSBTAP00000073259 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | SRY-box transcription factor 9. | 0.679 |
| FGF9 | AR | ENSBTAP00000055492 | ENSBTAP00000030053 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Androgen receptor. | 0.409 |
| FGF9 | DHH | ENSBTAP00000055492 | ENSBTAP00000000135 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.576 |
| FGF9 | DMRT1 | ENSBTAP00000055492 | ENSBTAP00000023667 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | 0.546 |
| FGF9 | INSRR | ENSBTAP00000055492 | ENSBTAP00000003973 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Tyrosine-protein kinase receptor. | 0.675 |
| FGF9 | SOX9 | ENSBTAP00000055492 | ENSBTAP00000073259 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | SRY-box transcription factor 9. | 0.695 |
| INSRR | FGF9 | ENSBTAP00000003973 | ENSBTAP00000055492 | Tyrosine-protein kinase receptor. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.675 |