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| NPC1L1 | NPC1 like intracellular cholesterol transporter 1. (1351 aa) | ||||
| ARL8B | ADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). (187 aa) | ||||
| LIMA1 | LIM domain and actin binding 1. (760 aa) | ||||
| ENSBTAP00000071915 | MENTAL domain-containing protein. (224 aa) | ||||
| ENSBTAP00000068322 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa) | ||||
| APOM | Apolipoprotein M. (223 aa) | ||||
| ABCG1 | ATP binding cassette subfamily G member 1. (679 aa) | ||||
| CD36 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor- ligand complexes. The depende [...] (472 aa) | ||||
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1220 aa) | ||||
| SPG11 | SPG11 vesicle trafficking associated, spatacsin. (2467 aa) | ||||
| ABCA5 | ATP binding cassette subfamily A member 5. (1562 aa) | ||||
| NPC1 | NPC intracellular cholesterol transporter 1. (1282 aa) | ||||
| TPCN2 | Two pore segment channel 2. (771 aa) | ||||
| LIPG | Lipase G, endothelial type. (500 aa) | ||||
| SERAC1 | Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). Belongs to the SERAC1 family. (654 aa) | ||||
| VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (473 aa) | ||||
| STARD4 | StAR related lipid transfer domain containing 4. (229 aa) | ||||
| LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) | ||||
| STARD3NL | STARD3 N-terminal like. (235 aa) | ||||
| CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa) | ||||
| STAR | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa) | ||||
| OSBPL2 | Oxysterol-binding protein; Belongs to the OSBP family. (480 aa) | ||||
| APOB | Apolipoprotein B. (4567 aa) | ||||
| SOAT1 | O-acyltransferase. (551 aa) | ||||
| CEL | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity); Belongs to the type-B ca [...] (599 aa) | ||||
| NPC2 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (By similarity). May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmos [...] (149 aa) | ||||
| ARV1 | Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes. Belongs to the ARV1 family. (282 aa) | ||||
| HNF1A | HNF1 homeobox A. (633 aa) | ||||
| ABCA1 | ATP binding cassette subfamily A member 1. (2261 aa) | ||||
| OSBP | Oxysterol-binding protein; Belongs to the OSBP family. (808 aa) | ||||
| APOA4 | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons (By similarity). (465 aa) | ||||
| APOA5 | Apolipoprotein A5. (368 aa) | ||||
| LCAT | Lecithin-cholesterol acyltransferase. (440 aa) | ||||
| PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (405 aa) | ||||
| ABCG8 | ATP binding cassette subfamily G member 8. (743 aa) | ||||
| ABCG5 | ATP binding cassette subfamily G member 5. (649 aa) | ||||
| SCARB1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. (509 aa) | ||||
| APOC3 | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (96 aa) | ||||
| LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (845 aa) | ||||
| ABCG4 | ATP binding cassette subfamily G member 4. (646 aa) | ||||
| STARD3 | StAR related lipid transfer domain containing 3. (448 aa) | ||||
| STARD5 | StAR-related lipid transfer protein 5; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). (213 aa) | ||||
| VPS4B | Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] (444 aa) | ||||
| APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (329 aa) | ||||
| APOA2 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Has antimicrobial activity. (100 aa) | ||||
| SOAT2 | O-acyltransferase. (535 aa) | ||||
| LIPC | Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). (500 aa) | ||||
| SCP2 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. (543 aa) | ||||
| ABCA12 | ATP binding cassette subfamily A member 12. (2596 aa) | ||||
| MSR1 | Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). (453 aa) | ||||
| APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (265 aa) | ||||
| TSKU | Tsukushi, small leucine rich proteoglycan. (344 aa) | ||||
| STX12 | STX12 protein; Belongs to the syntaxin family. (274 aa) | ||||
| LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (310 aa) | ||||
| PNLIP | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa) | ||||