STRINGSTRING
TLX3 TLX3 SOX9 SOX9 LMX1A LMX1A MEIS1 MEIS1 EIF4ENIF1 EIF4ENIF1 EIF4E EIF4E FOXG1 FOXG1 DLL1 DLL1 REST REST PAX6 PAX6 PBX1 PBX1 ZNF536 ZNF536 OLIG2 OLIG2 APP APP IRX3 IRX3 DISP3 DISP3 CNTN4 CNTN4 BMP7 BMP7 PHOX2B PHOX2B MED1 MED1 ITGB1 ITGB1 WNT3A WNT3A DLX2 DLX2 DIXDC1 DIXDC1 ZHX2 ZHX2 SHH SHH HES3 HES3 GLI3 GLI3 LBX1 LBX1 SOX8 SOX8 HMG20A HMG20A FEZF2 FEZF2 ISL2 ISL2 ASCL1 ASCL1 HEY1 HEY1 DLX1 DLX1 CALR CALR GPR37L1 GPR37L1 CNTN2 CNTN2 NR2E1 NR2E1 NOTCH1 NOTCH1 NKX2-2 NKX2-2 DDX6 DDX6 CTDSP1 CTDSP1 HOXA2 HOXA2 ASPM ASPM MIB1 MIB1 GDF11 GDF11 JAG1 JAG1 CDK5RAP2 CDK5RAP2 NEPRO NEPRO POU4F2 POU4F2 CNTF CNTF HES5 HES5 LSM1 LSM1 ISL1 ISL1 HES1 HES1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLX3Homeobox domain-containing protein. (291 aa)
SOX9SRY-box transcription factor 9. (524 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
MEIS1Meis homeobox 1. (465 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (984 aa)
EIF4EEukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). (217 aa)
FOXG1Forkhead box G1. (490 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
RESTUncharacterized protein. (1004 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
PBX1PBX homeobox 1. (325 aa)
ZNF536Zinc finger protein 536. (1378 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
IRX3Iroquois homeobox 3. (502 aa)
DISP3Dispatched RND transporter family member 3. (1393 aa)
CNTN4Contactin 4. (1026 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (802 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
DLX2Distal-less homeobox 2. (331 aa)
DIXDC1DIX domain containing 1. (472 aa)
ZHX2Zinc fingers and homeoboxes 2. (838 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
HES3Hes family bHLH transcription factor 3. (178 aa)
GLI3GLI family zinc finger 3. (1587 aa)
LBX1Ladybird homeobox 1. (282 aa)
SOX8SRY-box 8. (534 aa)
HMG20AHigh-mobility group 20A. (347 aa)
FEZF2Fez family zinc finger protein 2; Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. (459 aa)
ISL2ISL LIM homeobox 2. (359 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (304 aa)
DLX1Distal-less homeobox 1. (255 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa)
GPR37L1G-protein coupled receptor 37-like 1; G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulat [...] (613 aa)
CNTN2Contactin 2. (1040 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
NOTCH1Notch receptor 1. (2533 aa)
NKX2-2NK2 homeobox 2. (273 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
CTDSP1CTD small phosphatase 1. (260 aa)
HOXA2Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (372 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3461 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
GDF11Growth differentiation factor 11. (406 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1924 aa)
NEPRONucleolus and neural progenitor protein. (562 aa)
POU4F2POU domain protein. (407 aa)
CNTFCiliary neurotrophic factor. (199 aa)
HES5Hes family bHLH transcription factor 5. (227 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). (133 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HES1Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (280 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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