(23 nodes) mRNA 5-UTR binding network (Bos taurus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FMR1	Fragile X mental retardation 1. (632 aa)
	IGF2BP3	Insulin like growth factor 2 mRNA binding protein 3. (580 aa)
	CCT5	Chaperonin containing TCP1 subunit 5; Belongs to the TCP-1 chaperonin family. (541 aa)
	SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein. (638 aa)
	DHX36	ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4- RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template componen [...] (1010 aa)
	LARP1	La ribonucleoprotein domain family member 1. (1097 aa)
	RPS3A	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
	RPL5	60S ribosomal protein L5. (393 aa)
	GNL3	G protein nucleolar 3. (548 aa)
	MYH10	Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). (1976 aa)
	LARP6	La ribonucleoprotein domain family member 6. (492 aa)
	RPS14	Uncharacterized protein. (165 aa)
	SHMT1	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (484 aa)
	RSL1D1	Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent. (482 aa)
	RPL26	60S ribosomal protein L26. (145 aa)
	IGF2BP1	Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
	IGF2BP2	Insulin like growth factor 2 mRNA binding protein 2. (599 aa)
	SHMT2	Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] (504 aa)
	MRPS11	28S ribosomal protein S11, mitochondrial; Belongs to the universal ribosomal protein uS11 family. (197 aa)
	UTP23	rRNA-processing protein UTP23 homolog; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily. (248 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (661 aa)
	F1MR01_BOVIN	Uncharacterized protein. (151 aa)
	ENSBTAP00000058467	Uncharacterized protein. (147 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCT5	RSL1D1	ENSBTAP00000023778	ENSBTAP00000019422	Chaperonin containing TCP1 subunit 5; Belongs to the TCP-1 chaperonin family.	Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent.	0.491
DDX3X	DHX36	ENSBTAP00000047104	ENSBTAP00000008082	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4- RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template componen [...]	0.687
DDX3X	ENSBTAP00000058467	ENSBTAP00000047104	ENSBTAP00000058467	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.428
DDX3X	F1MR01_BOVIN	ENSBTAP00000047104	ENSBTAP00000048750	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.428
DDX3X	IGF2BP2	ENSBTAP00000047104	ENSBTAP00000035897	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	Insulin like growth factor 2 mRNA binding protein 2.	0.480
DDX3X	LARP1	ENSBTAP00000047104	ENSBTAP00000011109	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	La ribonucleoprotein domain family member 1.	0.430
DDX3X	MRPS11	ENSBTAP00000047104	ENSBTAP00000026421	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	28S ribosomal protein S11, mitochondrial; Belongs to the universal ribosomal protein uS11 family.	0.428
DDX3X	RPS14	ENSBTAP00000047104	ENSBTAP00000059968	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.428
DDX3X	RPS3A	ENSBTAP00000047104	ENSBTAP00000013079	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3.	0.479
DDX3X	RSL1D1	ENSBTAP00000047104	ENSBTAP00000019422	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent.	0.527
DDX3X	SYNCRIP	ENSBTAP00000047104	ENSBTAP00000008774	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	Synaptotagmin binding cytoplasmic RNA interacting protein.	0.520
DHX36	DDX3X	ENSBTAP00000008082	ENSBTAP00000047104	ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4- RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template componen [...]	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	0.687
DHX36	FMR1	ENSBTAP00000008082	ENSBTAP00000058546	ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4- RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template componen [...]	Fragile X mental retardation 1.	0.481
ENSBTAP00000058467	DDX3X	ENSBTAP00000058467	ENSBTAP00000047104	Uncharacterized protein.	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family.	0.428
ENSBTAP00000058467	F1MR01_BOVIN	ENSBTAP00000058467	ENSBTAP00000048750	Uncharacterized protein.	Uncharacterized protein.	0.547
ENSBTAP00000058467	MRPS11	ENSBTAP00000058467	ENSBTAP00000026421	Uncharacterized protein.	28S ribosomal protein S11, mitochondrial; Belongs to the universal ribosomal protein uS11 family.	0.540
ENSBTAP00000058467	RPL26	ENSBTAP00000058467	ENSBTAP00000016378	Uncharacterized protein.	60S ribosomal protein L26.	0.951
ENSBTAP00000058467	RPL5	ENSBTAP00000058467	ENSBTAP00000072536	Uncharacterized protein.	60S ribosomal protein L5.	0.939
ENSBTAP00000058467	RPS14	ENSBTAP00000058467	ENSBTAP00000059968	Uncharacterized protein.	Uncharacterized protein.	0.548
ENSBTAP00000058467	RPS3A	ENSBTAP00000058467	ENSBTAP00000013079	Uncharacterized protein.	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3.	0.916

page 1 of 6

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About