STRINGSTRING
LOC100336971 LOC100336971 CITED1 CITED1 BMP15 BMP15 INHBB INHBB JADE2 JADE2 TGFB2 TGFB2 TGFB1 TGFB1 SMAD5 SMAD5 NUP93 NUP93 SUB1 SUB1 SMAD1 SMAD1 HIPK2 HIPK2 GDF6 GDF6 ATOH8 ATOH8 GDF3 GDF3 HNF1A HNF1A GDF1 GDF1 NCEH1 NCEH1 ZMIZ1 ZMIZ1 BMP6 BMP6 INHBC INHBC TBXT TBXT VIM VIM BMP8A BMP8A BMP3 BMP3 AFP AFP GDF15 GDF15 SLC33A1 SLC33A1 SMAD2 SMAD2 NODAL NODAL HEXA HEXA BMP4 BMP4 BMP5 BMP5 SMAD3 SMAD3 HNF4A HNF4A TGFB3 TGFB3 MSTN MSTN INHA INHA GDF9 GDF9 ITGB6 ITGB6 SMAD9 SMAD9 GDF11 GDF11 TF TF SMAD4 SMAD4 INHBE INHBE BMP2 BMP2 GDF2 GDF2 GDF5 GDF5 FOS FOS JUN JUN RBM14 RBM14 GDF10 GDF10 BMP10 BMP10 SMAD6 SMAD6 SMAD7 SMAD7 LEFTY2 LEFTY2 F1MKJ7_BOVIN F1MKJ7_BOVIN GDF7 GDF7 BMP7 BMP7 SKI SKI BTBD11 BTBD11 BMP8B BMP8B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100336971Left-right determination factor. (367 aa)
CITED1Cbp/p300-interacting transactivator 1; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional c [...] (256 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (394 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (408 aa)
JADE2Jade family PHD finger 2. (861 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (442 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (499 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling. (819 aa)
SUB1SUB1 regulator of transcription. (167 aa)
SMAD1Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression; Belongs to the dwarfin/SMAD family. (465 aa)
HIPK2Homeodomain interacting protein kinase 2. (1206 aa)
GDF6Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...] (470 aa)
ATOH8Atonal bHLH transcription factor 8. (317 aa)
GDF3TGF_BETA_2 domain-containing protein. (364 aa)
HNF1AHNF1 homeobox A. (633 aa)
GDF1Growth differentiation factor 1. (369 aa)
NCEH1Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. (408 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1072 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
INHBCInhibin subunit beta C. (352 aa)
TBXTT-box transcription factor T. (435 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
BMP8ATGF_BETA_2 domain-containing protein. (405 aa)
BMP3Bone morphogenetic protein 3; Induces cartilage and bone formation. (475 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. (610 aa)
GDF15Growth differentiation factor 15. (308 aa)
SLC33A1Solute carrier family 33 (Acetyl-CoA transporter), member 1. (550 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
NODALNodal growth differentiation factor. (346 aa)
HEXABeta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (529 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (455 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa)
GDF9Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (808 aa)
SMAD9Mothers against decapentaplegic homolog. (455 aa)
GDF11Growth differentiation factor 11. (406 aa)
TFSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (704 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (553 aa)
INHBEInhibin subunit beta E. (348 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF2Growth differentiation factor 2. (431 aa)
GDF5Growth differentiation factor 5. (499 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (380 aa)
JUNTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (303 aa)
RBM14RNA-binding protein 14; May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the [...] (669 aa)
GDF10Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. (478 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SMAD6Mothers against decapentaplegic homolog. (529 aa)
SMAD7Mothers against decapentaplegic homolog. (430 aa)
LEFTY2Left-right determination factor. (367 aa)
F1MKJ7_BOVINTGF_BETA_2 domain-containing protein. (364 aa)
GDF7Growth differentiation factor 7. (450 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SKISKI proto-oncogene. (729 aa)
BTBD11BTB domain containing 11. (1108 aa)
BMP8BTGF_BETA_2 domain-containing protein. (405 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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