(15 nodes) Oxidative demethylation network (Bos taurus)

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Your Input:
	ALKBH5	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] (394 aa)
	JMJD6	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] (414 aa)
	TET2	Tet methylcytosine dioxygenase 2. (2007 aa)
	CYP3A5	Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa)
	ALKBH1	AlkB homolog 1, histone H2A dioxygenase. (389 aa)
	TET1	Tet methylcytosine dioxygenase 1. (2137 aa)
	CYP3A4	Uncharacterized protein. (503 aa)
	TET3	Tet methylcytosine dioxygenase 3. (1792 aa)
	ALKBH3	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1- methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of [...] (286 aa)
	FTO	FTO alpha-ketoglutarate dependent dioxygenase. (519 aa)
	ALKBH4	AlkB homolog 4, lysine demethylase. (377 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	ALKBH2	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). (278 aa)
	CYP3A24	Uncharacterized protein. (503 aa)
	CYP3A5-2	Cytochrome P450, family 3, subfamily A, polypeptide 5. (503 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH1	ALKBH2	ENSBTAP00000010693	ENSBTAP00000062950	AlkB homolog 1, histone H2A dioxygenase.	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	0.849
ALKBH1	ALKBH4	ENSBTAP00000010693	ENSBTAP00000004717	AlkB homolog 1, histone H2A dioxygenase.	AlkB homolog 4, lysine demethylase.	0.671
ALKBH1	ALKBH5	ENSBTAP00000010693	ENSBTAP00000034857	AlkB homolog 1, histone H2A dioxygenase.	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	0.712
ALKBH1	FTO	ENSBTAP00000010693	ENSBTAP00000065564	AlkB homolog 1, histone H2A dioxygenase.	FTO alpha-ketoglutarate dependent dioxygenase.	0.717
ALKBH1	TET1	ENSBTAP00000010693	ENSBTAP00000010614	AlkB homolog 1, histone H2A dioxygenase.	Tet methylcytosine dioxygenase 1.	0.409
ALKBH1	TET2	ENSBTAP00000010693	ENSBTAP00000023517	AlkB homolog 1, histone H2A dioxygenase.	Tet methylcytosine dioxygenase 2.	0.440
ALKBH1	TET3	ENSBTAP00000010693	ENSBTAP00000072621	AlkB homolog 1, histone H2A dioxygenase.	Tet methylcytosine dioxygenase 3.	0.459
ALKBH2	ALKBH1	ENSBTAP00000062950	ENSBTAP00000010693	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	AlkB homolog 1, histone H2A dioxygenase.	0.849
ALKBH2	ALKBH4	ENSBTAP00000062950	ENSBTAP00000004717	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	AlkB homolog 4, lysine demethylase.	0.832
ALKBH2	ALKBH5	ENSBTAP00000062950	ENSBTAP00000034857	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	0.668
ALKBH2	FTO	ENSBTAP00000062950	ENSBTAP00000065564	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	FTO alpha-ketoglutarate dependent dioxygenase.	0.696
ALKBH2	TET2	ENSBTAP00000062950	ENSBTAP00000023517	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	Tet methylcytosine dioxygenase 2.	0.403
ALKBH4	ALKBH1	ENSBTAP00000004717	ENSBTAP00000010693	AlkB homolog 4, lysine demethylase.	AlkB homolog 1, histone H2A dioxygenase.	0.671
ALKBH4	ALKBH2	ENSBTAP00000004717	ENSBTAP00000062950	AlkB homolog 4, lysine demethylase.	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	0.832
ALKBH4	ALKBH5	ENSBTAP00000004717	ENSBTAP00000034857	AlkB homolog 4, lysine demethylase.	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	0.706
ALKBH4	FTO	ENSBTAP00000004717	ENSBTAP00000065564	AlkB homolog 4, lysine demethylase.	FTO alpha-ketoglutarate dependent dioxygenase.	0.603
ALKBH5	ALKBH1	ENSBTAP00000034857	ENSBTAP00000010693	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	AlkB homolog 1, histone H2A dioxygenase.	0.712
ALKBH5	ALKBH2	ENSBTAP00000034857	ENSBTAP00000062950	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single- stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).	0.668
ALKBH5	ALKBH4	ENSBTAP00000034857	ENSBTAP00000004717	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	AlkB homolog 4, lysine demethylase.	0.706
ALKBH5	FTO	ENSBTAP00000034857	ENSBTAP00000065564	RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...]	FTO alpha-ketoglutarate dependent dioxygenase.	0.987

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