Your Input: | |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (233 aa) |
| | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ES [...] (777 aa) |
| | NSG2 | Neuronal vesicle trafficking-associated protein 2. (171 aa) |
| | SNX10 | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption (By similarity). (200 aa) |
| | PI4K2A | PI4K2A protein. (479 aa) |
| | SNX1 | Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa) |
| | TM9SF1 | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (606 aa) |
| | DNAJC13 | DnaJ heat shock protein family (Hsp40) member C13. (2243 aa) |
| | SLC9A7 | Solute carrier family 9 member A7. (690 aa) |
| | ACAP2 | Uncharacterized protein. (567 aa) |
| | MVB12A | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family. (273 aa) |
| | SNX20 | Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. (316 aa) |
| | RAP2C | Ras-related protein Rap-2c; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription (By similarity). (183 aa) |
| | VPS36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may a [...] (386 aa) |
| | TMEM184A | Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). (414 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (236 aa) |
| | FIG4 | FIG4 phosphoinositide 5-phosphatase. (907 aa) |
| | VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). (307 aa) |
| | CD274 | Programmed cell death-ligand 1. (289 aa) |
| | CHMP4A | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (222 aa) |
| | EHD4 | EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa) |
| | ABHD17B | Abhydrolase domain containing 17B. (288 aa) |
| | E1BJA7_BOVIN | Uncharacterized protein. (154 aa) |
| | SCAMP1 | Secretory carrier-associated membrane protein. (354 aa) |
| | CHMP2B | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa) |
| | LAMP5 | Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. (280 aa) |
| | VPS37C | VPS37C subunit of ESCRT-I. (350 aa) |
| | UBXN6 | UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. (441 aa) |
| | VPS37D | VPS37D subunit of ESCRT-I. (251 aa) |
| | SPHK1 | Sphingosine kinase 1. (489 aa) |
| | CXHXorf21 | Protein CXorf21 homolog; Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. May be involved in endolysosomal-dependent immune responses. (300 aa) |
| | KCNH1 | Potassium voltage-gated channel subfamily H member 1; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow- derived mesenchymal stem cells (MSCs) (By similarity). (987 aa) |
| | LOC515333 | Uncharacterized protein. (1250 aa) |
| | VPS37A | Vacuolar protein sorting 37 homolog A (S. cerevisiae). (397 aa) |
| | VPS4B | Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] (444 aa) |
| | MON2 | MON2 homolog, regulator of endosome-to-Golgi trafficking. (1720 aa) |
| | RNF13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (380 aa) |
| | SNX4 | Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. (450 aa) |
| | KCNH5 | Potassium voltage-gated channel subfamily H member 5. (988 aa) |
| | WDR81 | WD repeat domain 81. (1948 aa) |
| | F1N7E4_BOVIN | Uncharacterized protein. (107 aa) |
| | USP50 | Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (378 aa) |
| | F1MY67_BOVIN | Uncharacterized protein. (231 aa) |
| | TMEM19 | Transmembrane protein 19. (336 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (219 aa) |
| | SNX6 | Sorting nexin 6. (304 aa) |
| | F1MFJ1_BOVIN | RING-type domain-containing protein. (325 aa) |
| | MREG | Melanoregulin. (214 aa) |
| | CHMP4B | Charged multivesicular body protein 4B. (224 aa) |
| | CHMP7 | Charged multivesicular body protein 7. (450 aa) |
| | TSG101 | Tumor susceptibility 101. (391 aa) |
| | UEVLD | UEV and lactate/malate dehyrogenase domains. (471 aa) |
| | SNX8 | Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Belongs to the sorting nexin family. (459 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (201 aa) |
| | BAIAP3 | BAI1 associated protein 3. (1152 aa) |
| | DOP1B | DOP1 leucine zipper like protein B. (1948 aa) |
| | SORL1 | Sortilin related receptor 1. (2211 aa) |
| | WDR53 | WD repeat-containing protein 53; Belongs to the WD repeat WDR53 family. (358 aa) |
| | LAMTOR5 | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (91 aa) |
| | LAMTOR4 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). (99 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | RAB8A | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa) |
| | ATP13A4 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1197 aa) |
| | ABHD6 | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] (337 aa) |
| | LAPTM4B | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] (226 aa) |
| | RAB11FIP4 | RAB11 family interacting protein 4. (593 aa) |
| | WDR91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. (746 aa) |
| | CYB561A3 | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity). (265 aa) |
| | TMEM108 | Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrit [...] (587 aa) |
| | TMEM163 | Transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles; Belongs to the TMEM163 family. (287 aa) |
| | SNX3 | Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo- selective subcomplex (CSC). May act in part as component of the SNX3- retromer complex which mediates the retrograde [...] (162 aa) |
| | SLC39A14 | Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. (490 aa) |
| | CMTM6 | CKLF like MARVEL transmembrane domain containing 6. (182 aa) |
| | MICALL1 | MICAL-like protein 1; Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth (By similarity). (853 aa) |
| | SNX16 | Sorting nexin 16. (343 aa) |
| | CLIP3 | CAP-Gly domain containing linker protein 3. (547 aa) |
| | VPS25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity). (176 aa) |
| | KREMEN2 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6. (843 aa) |
| | ATG9A | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (839 aa) |
| | SLC36A2 | Solute carrier family 36 member 2. (482 aa) |
| | EHD2 | EH-domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa) |
| | PIP4P2 | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylino [...] (257 aa) |
| | RAB35 | RAB35, member RAS oncogene family. (201 aa) |
| | SLC15A3 | Solute carrier family 15 member 3. (581 aa) |
| | ATP11B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1167 aa) |
| | VAMP8 | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (100 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1085 aa) |
| | ZFYVE28 | Zinc finger FYVE-type containing 28. (845 aa) |
| | ABHD17A | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6; Belongs to the AB hydrolase superfamily. ABHD17 family. (310 aa) |
| | LOC100337076 | Uncharacterized protein. (1156 aa) |
| | LOC100337390 | Uncharacterized protein. (1309 aa) |
| | SNX2 | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (519 aa) |
| | SNX5 | Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-me [...] (404 aa) |
| | TMEM9B | TMEM9 domain family, member B. (198 aa) |
| | TBC1D5 | TBC1 domain family member 5. (809 aa) |
| | LLGL1 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane (By similarity); Belongs to the WD repeat L(2)GL family. (1153 aa) |
| | PLD3 | 5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (490 aa) |
| | EHD3 | EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) |
| | LAMP1 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. (409 aa) |
| | ABCB11 | ATP binding cassette subfamily B member 11. (1324 aa) |
| | ABHD17C | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. (329 aa) |
| | SCAMP3 | Secretory carrier-associated membrane protein 3; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity); Belongs to the SCAMP family. (347 aa) |
| | SPRYD3 | SPRY domain containing 3. (442 aa) |
| | PI4K2B | PI3K/PI4K domain-containing protein. (487 aa) |
| | CHMP1A | Charged multivesicular body protein 1A. (263 aa) |
| | LAMTOR3 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] (124 aa) |
| | LAMTOR2 | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] (125 aa) |
| | MDP1 | Uncharacterized protein. (164 aa) |
| | SLC30A4 | Zinc transporter 4; Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment. (429 aa) |
| | SLC29A3 | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity); Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. (536 aa) |
| | ZFYVE9 | Zinc finger FYVE domain-containing protein. (1421 aa) |
| | G3N0N8_BOVIN | Uncharacterized protein. (200 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (473 aa) |
| | G3N2K6_BOVIN | Uncharacterized protein. (91 aa) |
| | TPC3 | Two pore channel 3. (768 aa) |
| | CLCN4 | Chloride channel protein. (782 aa) |
| | VPS28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. (230 aa) |
| | PLD4 | Phospholipase D family member 4. (547 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. (281 aa) |
| | CD300LG | CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity); Belongs to the CD300 family. (258 aa) |
| | TMEM9 | TMEM9 protein. (181 aa) |
| | ACAP2-2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2. (282 aa) |
| | ENSBTAP00000058288 | Uncharacterized protein. (262 aa) |
| | RAB11FIP3 | RAB11 family interacting protein 3. (741 aa) |
| | LOC100848700 | Uncharacterized protein. (1262 aa) |
| | SNX21 | PX domain-containing protein. (371 aa) |
| | LAMTOR1 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] (218 aa) |
| | NDRG1 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulat [...] (415 aa) |
| | RNF167 | Ring finger protein 167. (349 aa) |
| | ENSBTAP00000060718 | PX domain-containing protein. (233 aa) |
| | CDIP1 | Cell death-inducing p53-target protein 1; Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. Belongs to the CDIP1/LITAF family. (208 aa) |
| | MVB12B | Multivesicular body subunit 12B. (347 aa) |
| | ENSBTAP00000060911 | Uncharacterized protein. (154 aa) |
| | LITAF | Lipopolysaccharide induced TNF factor. (186 aa) |
| | ZNRF4 | Zinc and ring finger 4. (338 aa) |
| | C8H9orf85 | Uncharacterized protein. (165 aa) |
| | ENSBTAP00000061428 | Uncharacterized protein. (88 aa) |
| | MR1 | Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent; Belongs to the MHC c [...] (340 aa) |
| | LOC521568 | Uncharacterized protein. (1280 aa) |
| | SLC38A9 | Solute carrier family 38 member 9. (561 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons 2. (486 aa) |
| | LOC523126 | Uncharacterized protein. (1195 aa) |
| | TPCN2 | Two pore segment channel 2. (771 aa) |
| | SYNDIG1 | Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. (264 aa) |
| | NPC1 | NPC intracellular cholesterol transporter 1. (1282 aa) |
| | GRIPAP1 | GRIP1 associated protein 1. (882 aa) |
| | CLEC16A | C-type lectin domain containing 16A. (1050 aa) |
| | LZTR1 | Leucine zipper like transcription regulator 1. (979 aa) |
| | SLC15A4 | Solute carrier family 15 member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity); Belongs to the PTR2/POT transporter (TC 2.A.17) family. (566 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1276 aa) |
| | PLA2G4E | Phospholipase A2. (836 aa) |
| | C4H7orf25 | UPF0415 protein C7orf25 homolog; Belongs to the UPF0415 family. (431 aa) |
| | TMEM175 | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Belongs to the TMEM175 family. (504 aa) |
| | ATP13A5 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1219 aa) |
| | VAMP7 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (152 aa) |
| | NSG1 | Neuronal vesicle trafficking associated 1. (185 aa) |
| | RAB5C | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (228 aa) |
| | EHD1 | EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary v [...] (534 aa) |
| | LOC520016 | Uncharacterized protein. (1181 aa) |
| | CHMP3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (250 aa) |
| | LDLRAD4 | Low density lipoprotein receptor class A domain containing 4. (332 aa) |
| | ENSBTAP00000068879 | Dopey_N domain-containing protein. (209 aa) |
| | RAP2A | RAP2A, member of RAS oncogene family. (231 aa) |
| | SCAMP2 | Secretory carrier-associated membrane protein. (344 aa) |
| | ENSBTAP00000070506 | Uncharacterized protein. (116 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] (417 aa) |
| | RAP2B | RAP2B protein. (183 aa) |
| | LOC100299180 | Uncharacterized protein. (1223 aa) |
| | TMEM184B | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. (414 aa) |
| | PMEPA1 | Uncharacterized protein. (339 aa) |
| | UBAP1L | Ubiquitin associated protein 1 like. (380 aa) |
| | CD63 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] (276 aa) |
| | ENSBTAP00000072838 | Uncharacterized protein. (246 aa) |
| | SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (275 aa) |
| | UBAP1 | Ubiquitin associated protein 1. (503 aa) |
| | VPS37B | VPS37 C-terminal domain-containing protein. (289 aa) |
| | ENSBTAP00000073746 | Uncharacterized protein. (91 aa) |
| | TPCN1 | Two pore segment channel 1. (1032 aa) |
| | WIPI1 | WD repeat domain, phosphoinositide interacting 1. (504 aa) |
