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| | HNRNPC | Heterogeneous nuclear ribonucleoprotein C (C1/C2). (294 aa) |
| | G3BP2 | G3BP stress granule assembly factor 2. (482 aa) |
| | ENSBTAP00000067814 | G-patch domain-containing protein. (401 aa) |
| | LOC112445421 | RRM domain-containing protein. (187 aa) |
| | SLTM | SAFB like transcription modulator. (967 aa) |
| | ENSBTAP00000068474 | Uncharacterized protein. (464 aa) |
| | HNRNPR | Heterogeneous nuclear ribonucleoprotein R. (641 aa) |
| | PPARGC1B | PPARG coactivator 1 beta. (1049 aa) |
| | ENSBTAP00000068843 | Uncharacterized protein. (385 aa) |
| | SETD1A | SET domain containing 1A, histone lysine methyltransferase. (1708 aa) |
| | ENSBTAP00000068902 | Uncharacterized protein. (217 aa) |
| | ELAVL4 | ELAV-like protein; Belongs to the RRM elav family. (371 aa) |
| | ENSBTAP00000069032 | RRM domain-containing protein. (205 aa) |
| | ENSBTAP00000069705 | RRM domain-containing protein. (282 aa) |
| | LOC538435 | Uncharacterized protein. (372 aa) |
| | HNRNPH3 | Heterogeneous nuclear ribonucleoprotein H3. (351 aa) |
| | RBFOX1 | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis (By similarity). (400 aa) |
| | TIA1 | TIA1 cytotoxic granule associated RNA binding protein. (388 aa) |
| | ENSBTAP00000070180 | RRM domain-containing protein. (212 aa) |
| | MTHFSD | Methenyltetrahydrofolate synthase domain-containing protein. (380 aa) |
| | ENSBTAP00000070435 | Uncharacterized protein. (176 aa) |
| | CPSF6 | Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (588 aa) |
| | RBM19 | RNA binding motif protein 19. (947 aa) |
| | PTBP2 | Polypyrimidine tract binding protein 2. (532 aa) |
| | CELF1 | CUGBP Elav-like family member 1. (513 aa) |
| | ENSBTAP00000071377 | RRM domain-containing protein. (157 aa) |
| | ENSBTAP00000071472 | RRM domain-containing protein. (241 aa) |
| | EWSR1 | EWS RNA binding protein 1. (762 aa) |
| | ENSBTAP00000072021 | RRM domain-containing protein. (125 aa) |
| | SYNJ1 | Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. Belongs to the synaptojanin family. (1579 aa) |
| | ENSBTAP00000072417 | RRM domain-containing protein. (131 aa) |
| | RBM26 | RNA binding motif protein 26. (1007 aa) |
| | ENSBTAP00000073070 | RRM domain-containing protein. (100 aa) |
| | SRSF5 | Serine and arginine rich splicing factor 5. (272 aa) |
| | CELF6 | Uncharacterized protein. (480 aa) |
| | ENSBTAP00000073754 | RRM domain-containing protein. (196 aa) |
| | TDRD10 | Tudor domain containing 10. (382 aa) |
| | RBM10 | RNA binding motif protein 10. (1072 aa) |
| | RAVER2 | Ribonucleoprotein, PTB binding 2. (683 aa) |
| | HNRNPH1 | Heterogeneous nuclear ribonucleoprotein H1. (472 aa) |
| | ENSBTAP00000074364 | RRM domain-containing protein. (181 aa) |
| | U2AF1L4 | Splicing factor U2AF 26 kDa subunit; RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarit [...] (257 aa) |
| | HNRNPM | Heterogeneous nuclear ribonucleoprotein M. (730 aa) |
| | EIF4H | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). (345 aa) |
| | TARDBP | TAR DNA binding protein. (414 aa) |
| | SRSF12 | Serine and arginine rich splicing factor 12. (261 aa) |
| | SPEN | Spen family transcriptional repressor. (3640 aa) |
| | RBM12 | RNA binding motif protein 12. (953 aa) |
| | RBMS3 | RNA binding motif single stranded interacting protein 3. (436 aa) |
| | TNRC6C | Trinucleotide repeat containing adaptor 6C. (1931 aa) |
| | RBM34 | Uncharacterized protein. (428 aa) |
| | RBM15 | RNA binding motif protein 15. (962 aa) |
| | MATR3 | Uncharacterized protein. (844 aa) |
| | SRSF3 | Serine/arginine-rich splicing factor 3; Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. [...] (164 aa) |
| | DAZL | Deleted in azoospermia-like transcript variant 1. (295 aa) |
| | RBM11 | RNA binding motif protein 11. (346 aa) |
| | SNRNP35 | U11/U12 small nuclear ribonucleoprotein 35 kDa protein. (245 aa) |
| | RBM20 | RNA binding motif protein 20. (1210 aa) |
| | CSTF2 | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). (592 aa) |
| | SART3 | Spliceosome associated factor 3, U4/U6 recycling protein. (957 aa) |
| | BOLL | Boule homolog, RNA binding protein. (295 aa) |
| | SAFB2 | Scaffold attachment factor B2. (948 aa) |
| | RALY | RNA binding protein (Autoantigenic, hnRNP-associated with lethal yellow) short isoform. (283 aa) |
| | SLIRP | SRA stem-loop-interacting RNA-binding protein, mitochondrial; RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). (111 aa) |
| | RBM22 | Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses; Belongs to the SLT11 family. (420 aa) |
| | SNRPB2 | Small nuclear ribonucleoprotein polypeptide B2. (218 aa) |
| | SYNJ2 | Synaptojanin 2. (1487 aa) |
| | G3X7M4_BOVIN | Uncharacterized protein. (462 aa) |
| | RBM24 | RNA binding motif protein 24. (236 aa) |
| | SRSF4 | Serine and arginine rich splicing factor 4. (493 aa) |
| | ESRP1 | Epithelial splicing regulatory protein 1. (677 aa) |
| | IGF2BP2 | Insulin like growth factor 2 mRNA binding protein 2. (599 aa) |
| | CELF3 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity); Belongs to the CELF/BRUNOL family. (461 aa) |
| | A1CF | APOBEC1 complementation factor. (587 aa) |
| | SRSF7 | Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi- sequence specific (By similarity); Belongs to the splicing factor SR family. (235 aa) |
| | PPRC1 | PPARG related coactivator 1. (1666 aa) |
| | PABPN1L | RRM domain-containing protein. (267 aa) |
| | HNRNPL | Heterogeneous nuclear ribonucleoprotein L. (588 aa) |
| | NIFK | MKI67 FHA domain-interacting nucleolar phosphoprotein. (296 aa) |
| | RBM17 | RNA binding motif protein 17. (401 aa) |
| | CELF5 | CUGBP Elav-like family member 5. (170 aa) |
| | HNRNPA3 | Heterogeneous nuclear ribonucleoprotein A3. (380 aa) |
| | HNRNPLL | Heterogeneous nuclear ribonucleoprotein L like. (541 aa) |
| | LOC540405 | Uncharacterized protein. (395 aa) |
| | ZRSR2 | Uncharacterized protein. (405 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). (1741 aa) |
| | G3BP1 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] (465 aa) |
| | PABPC5 | Poly(A) binding protein cytoplasmic 5. (382 aa) |
| | LOC536148 | RRM domain-containing protein. (927 aa) |
| | IGF2BP3 | Insulin like growth factor 2 mRNA binding protein 3. (580 aa) |
| | ZCRB1 | Zinc finger CCHC-type and RNA-binding motif-containing protein 1. (217 aa) |
| | DND1 | DND microRNA-mediated repression inhibitor 1. (355 aa) |
| | NOL8 | RRM domain-containing protein. (1160 aa) |
| | RBM48 | RNA-binding protein 48. (362 aa) |
| | SRSF2 | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...] (221 aa) |
| | RBM3 | RNA binding motif protein 3. (160 aa) |
| | RBMS2 | RNA-binding motif, single-stranded-interacting protein 2. (407 aa) |
| | RALYL | RNA-binding Raly-like protein; Belongs to the RRM HNRPC family. RALY subfamily. (271 aa) |
| | RBM25 | RNA binding motif protein 25. (843 aa) |
| | PABPC4 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (645 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (819 aa) |
| | RBM28 | RNA binding motif protein 28. (751 aa) |
| | PPIL4 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (492 aa) |
| | SETD1B | SET domain containing 1B, histone lysine methyltransferase. (1793 aa) |
| | HNRNPA0 | Heterogeneous nuclear ribonucleoprotein A0. (314 aa) |
| | PABPC1L | Poly(A) binding protein cytoplasmic 1 like. (300 aa) |
| | POLDIP3 | Polymerase (DNA-directed), delta interacting protein 3. (421 aa) |
| | PABPN1 | Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription [...] (306 aa) |
| | RBM18 | Probable RNA-binding protein 18. (190 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (707 aa) |
| | RBM43 | RNA binding motif protein 43. (343 aa) |
| | NCL | Uncharacterized protein. (720 aa) |
| | RAVER1 | Ribonucleoprotein, PTB binding 1. (733 aa) |
| | SRSF11 | Serine and arginine rich splicing factor 11. (482 aa) |
| | RBM33 | RNA binding motif protein 33. (1209 aa) |
| | HNRNPDL | Heterogeneous nuclear ribonucleoprotein D like. (420 aa) |
| | G5E5I0_BOVIN | RRM domain-containing protein. (321 aa) |
| | DNAJC17 | DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription. (304 aa) |
| | RBM12B | RNA binding motif protein 12B. (867 aa) |
| | RBMX | RNA-binding motif protein, X chromosome. (391 aa) |
| | SRSF9 | Serine and arginine rich splicing factor 9. (221 aa) |
| | UHMK1 | U2AF homology motif kinase 1. (419 aa) |
| | TRA2A | Transformer 2 alpha homolog (Drosophila). (281 aa) |
| | SF3B4 | Splicing factor 3b subunit 4. (424 aa) |
| | ENOX1 | Ecto-NOX disulfide-thiol exchanger 1. (624 aa) |
| | NONO | Non-POU domain containing, octamer-binding. (470 aa) |
| | TUT1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher tha [...] (871 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (577 aa) |
| | U2AF1 | Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity); Belongs to the splicing factor SR family. (237 aa) |
| | RBM27 | Uncharacterized protein. (1058 aa) |
| | ACIN1 | Apoptotic chromatin condensation inducer 1. (1334 aa) |
| | F1N235_BOVIN | Uncharacterized protein. (369 aa) |
| | RBPMS2 | RNA binding protein, mRNA processing factor 2. (211 aa) |
| | ABT1 | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). (275 aa) |
| | RBM44 | RNA-binding protein 44; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity). (1051 aa) |
| | ALKBH8 | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in [...] (671 aa) |
| | TRNAU1AP | tRNA selenocysteine 1-associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity). (287 aa) |
| | CPEB3 | Cytoplasmic polyadenylation element binding protein 3. (697 aa) |
| | CPEB4 | Cytoplasmic polyadenylation element binding protein 4. (729 aa) |
| | HNRNPA1 | Uncharacterized protein. (373 aa) |
| | MSI1 | Musashi RNA binding protein 1. (362 aa) |
| | NUP35 | Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (349 aa) |
| | ZNF638 | Zinc finger protein 638. (1971 aa) |
| | U2SURP | U2 snRNP associated SURP domain containing. (425 aa) |
| | SNRPA | U1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). (282 aa) |
| | CELF2 | CUGBP Elav-like family member 2. (519 aa) |
| | NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] (156 aa) |
| | HNRNPF | Heterogeneous nuclear ribonucleoprotein F, N-terminally processed; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). (414 aa) |
| | SSB | Lupus La protein homolog; Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. (404 aa) |
| | GRSF1 | G-rich RNA sequence binding factor 1. (481 aa) |
| | SRSF6 | Serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre- mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity); Belongs to the splicing factor SR family. (345 aa) |
| | ALYREF | THO complex subunit 4; Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a regio [...] (257 aa) |
| | RBM8A | RNA-binding protein 8A; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain [...] (501 aa) |
| | RBM7 | RNA-binding protein 7; RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre- mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRN [...] (262 aa) |
| | RBM38 | RNA binding motif protein 38. (239 aa) |
| | SRSF10 | FUS interacting protein (Serine/arginine-rich) 1. (182 aa) |
| | HNRNPH2 | Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity). (449 aa) |
| | EIF3B | Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (786 aa) |
| | NELFE | Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity). (374 aa) |
| | SREK1 | Splicing regulatory glutamic acid and lysine rich protein 1. (632 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (622 aa) |
| | EIF4B | Eukaryotic translation initiation factor 4B. (610 aa) |
| | SYNCRIP | Synaptotagmin binding cytoplasmic RNA interacting protein. (638 aa) |
| | RBM15B | Uncharacterized protein. (894 aa) |
| | REXO5 | RNA exonuclease 5. (783 aa) |
| | RBM5 | RNA-binding protein 5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Cas [...] (815 aa) |
| | RBM6 | RNA binding motif protein 6. (1120 aa) |
| | RBFOX3 | RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). (370 aa) |
| | RBM45 | RNA binding motif protein 45. (474 aa) |
| | FUS | RNA-binding protein FUS; DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination [...] (512 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and he [...] (341 aa) |
| | RBMS1 | RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the C-myc gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity). (422 aa) |
| | CELF4 | CUGBP Elav-like family member 4. (475 aa) |
| | PSPC1 | Paraspeckle component 1; Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP- RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent inn [...] (520 aa) |
| | CIRBP | Cold inducible RNA binding protein. (213 aa) |
| | SF3B6 | Splicing factor 3B, 14 kDa subunit. (125 aa) |
| | MCM3AP | Minichromosome maintenance complex component 3 associated protein. (1979 aa) |
| | EIF3G | Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (320 aa) |
| | SAFB | SAFB protein. (903 aa) |
| | TRA2B | Transformer-2 protein homolog beta; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity); Belongs to the splicing factor SR family. (288 aa) |
| | RBM46 | RNA binding motif protein 46. (533 aa) |
| | ENSBTAP00000067468 | Uncharacterized protein. (262 aa) |
| | RBM14 | RNA-binding protein 14; May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the [...] (669 aa) |
| | CPEB1 | Uncharacterized protein. (603 aa) |
| | ELAVL1 | ELAV-like protein; Belongs to the RRM elav family. (326 aa) |
| | RBM4 | RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] (362 aa) |
| | RDM1 | RAD52 motif containing 1. (285 aa) |
| | G3MYE8_BOVIN | RRM domain-containing protein. (326 aa) |
| | G3MYJ0_BOVIN | Uncharacterized protein. (449 aa) |
| | PABPC1L2A | Uncharacterized protein. (210 aa) |
| | CSTF2T | Cleavage stimulation factor subunit 2 tau variant. (632 aa) |
| | PABPC1L2A-2 | Uncharacterized protein. (213 aa) |
| | PPIE | Peptidyl-prolyl cis-trans isomerase E; Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'- UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. (301 aa) |
| | LOC508834 | RRM domain-containing protein. (294 aa) |
| | G3N220_BOVIN | RRM domain-containing protein. (373 aa) |
| | RBMXL2 | RNA-binding motif protein, X chromosome, N-terminally processed; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the suprasplic [...] (396 aa) |
| | HTATSF1-2 | HIV-1 Tat specific factor 1. (740 aa) |
| | PABPC1 | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] (636 aa) |
| | LOC614922 | Uncharacterized protein. (321 aa) |
| | ENSBTAP00000056942 | Uncharacterized protein. (357 aa) |
| | ENSBTAP00000057022 | RRM domain-containing protein. (152 aa) |
| | ENSBTAP00000057187 | RRM domain-containing protein. (101 aa) |
| | PTBP3 | Polypyrimidine tract binding protein 3. (556 aa) |
| | RBM47 | RNA binding motif protein 47. (591 aa) |
| | ENSBTAP00000057776 | Uncharacterized protein. (542 aa) |
| | LOC534630 | RRM domain-containing protein. (330 aa) |
| | SCAF4 | SR-related CTD associated factor 4. (1143 aa) |
| | ENOX2 | Ecto-NOX disulfide-thiol exchanger 2. (581 aa) |
| | SNRNP70-2 | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1- snRNA. (166 aa) |
| | RBM4B | RNA binding motif protein 4B. (359 aa) |
| | SRSF1 | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] (253 aa) |
| | ENSBTAP00000059270 | Uncharacterized protein. (407 aa) |
| | ENSBTAP00000059433 | RRM domain-containing protein. (188 aa) |
| | MSI2 | Uncharacterized protein. (362 aa) |
| | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1. (405 aa) |
| | RBM39 | RNA binding motif protein 39. (530 aa) |
| | ENSBTAP00000060201 | RRM domain-containing protein. (253 aa) |
| | LOC788414 | RRM domain-containing protein. (657 aa) |
| | RBM23 | RNA binding motif protein 23. (464 aa) |
| | HTATSF1 | Uncharacterized protein. (773 aa) |
| | PABPC4L | Poly(A) binding protein cytoplasmic 4 like. (370 aa) |
| | ENSBTAP00000060658 | RRM domain-containing protein. (120 aa) |
| | PABPN1L-2 | RRM domain-containing protein. (164 aa) |
| | SCAF8 | SR-related CTD associated factor 8. (1268 aa) |
| | CPEB2 | Cytoplasmic polyadenylation element binding protein 2. (595 aa) |
| | PUF60 | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice si [...] (562 aa) |
| | RNPS1 | RNA-binding protein with serine-rich domain 1; Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the E [...] (367 aa) |
| | ELAVL3 | ELAV-like protein; Belongs to the RRM elav family. (360 aa) |
| | LARP7 | La ribonucleoprotein domain family member 7. (594 aa) |
| | LOC785761 | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. (320 aa) |
| | RNPC3 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA (By similarity). (517 aa) |
| | ENSBTAP00000062497 | RRM domain-containing protein. (168 aa) |
| | ENSBTAP00000062511 | Uncharacterized protein. (221 aa) |
| | MYEF2 | Myelin expression factor 2. (600 aa) |
| | HNRNPAB | Heterogeneous nuclear ribonucleoprotein A/B. (332 aa) |
| | ENSBTAP00000062711 | Uncharacterized protein. (231 aa) |
| | LARP6 | La ribonucleoprotein domain family member 6. (492 aa) |
| | RBM41 | RNA binding motif protein 41. (437 aa) |
| | ENSBTAP00000063402 | RRM domain-containing protein. (144 aa) |
| | U2AF2 | U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa) |
| | RBM42 | RNA-binding protein 42; Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. (477 aa) |
| | ELAVL2 | ELAV-like protein; Belongs to the RRM elav family. (389 aa) |
| | ENSBTAP00000064186 | RRM domain-containing protein. (103 aa) |
| | TRMT2A | tRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (629 aa) |
| | ENSBTAP00000064424 | Uncharacterized protein. (168 aa) |
| | ENSBTAP00000064452 | RRM domain-containing protein. (170 aa) |
| | RBMX2 | RRM domain-containing protein. (358 aa) |
| | DAZAP1 | DAZ associated protein 1. (406 aa) |
| | ENSBTAP00000064951 | RRM domain-containing protein. (268 aa) |
| | CNOT4 | CCR4-NOT transcription complex subunit 4. (713 aa) |
| | ENSBTAP00000065555 | RRM domain-containing protein. (184 aa) |
| | LOC112445518 | Uncharacterized protein. (209 aa) |
| | CPSF7 | Cleavage and polyadenylation specific factor 7. (471 aa) |
| | RBFOX2 | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). (451 aa) |
| | PTBP1 | Polypyrimidine tract-binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10 (By similarity). (557 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D. (403 aa) |
| | RRP7A | Uncharacterized protein. (280 aa) |
| | RBPMS | RNA binding protein, mRNA processing factor. (487 aa) |
