STRINGSTRING
CHID1 CHID1 CHIA CHIA HYAL1 HYAL1 HYAL2 HYAL2 GUSB GUSB GALC GALC FUCA2 FUCA2 SPAM1 SPAM1 LCTL LCTL HYAL4 HYAL4 HPSE HPSE CTBS CTBS LOC100138271 LOC100138271 AGL AGL GANC GANC NAGA NAGA LOC613282 LOC613282 GLB1L2 GLB1L2 HEXA HEXA SLC3A2 SLC3A2 KL KL KLB KLB LCT LCT GLB1 GLB1 GAA GAA OGA OGA GANAB GANAB SLC3A1 SLC3A1 SI SI HEXD HEXD CHI3L1 CHI3L1 AMY2B AMY2B GLA GLA MANBA MANBA GBA3 GBA3 GLB1L GLB1L F1MVE6_BOVIN F1MVE6_BOVIN FUCA1 FUCA1 LOC509761 LOC509761 LOC786974 LOC786974 HEXB HEXB OVGP1 OVGP1 LOC527125 LOC527125 LOC539383 LOC539383 MGAM MGAM LOC112445747 LOC112445747 NAGLU NAGLU HPSE2 HPSE2 GBA GBA ENSBTAP00000061280 ENSBTAP00000061280 IDUA IDUA GLB1L3 GLB1L3 HYAL3 HYAL3 GBE1 GBE1 ENSBTAP00000072907 ENSBTAP00000072907 CHI3L2 CHI3L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHID1Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). (394 aa)
CHIAAcidic mammalian chitinase; Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on [...] (472 aa)
HYAL1Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). (450 aa)
HYAL2Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family. (473 aa)
GUSBBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (652 aa)
GALCGalactosylceramidase. (690 aa)
FUCA2Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (465 aa)
SPAM1Hyaluronidase. (553 aa)
LCTLLactase like; Belongs to the glycosyl hydrolase 1 family. (567 aa)
HYAL4Hyaluronidase. (481 aa)
HPSEHeparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inact [...] (553 aa)
CTBSDi-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family. (377 aa)
LOC100138271Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (479 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1532 aa)
GANCGlucosidase alpha, neutral C; Belongs to the glycosyl hydrolase 31 family. (914 aa)
NAGAAlpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity); Belongs to the glycosyl hydrolase 27 family. (411 aa)
LOC613282Glyco_hydro_35 domain-containing protein; Belongs to the glycosyl hydrolase 35 family. (703 aa)
GLB1L2Beta-galactosidase. (635 aa)
HEXABeta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (529 aa)
SLC3A2Solute carrier family 3 member 2. (572 aa)
KLKlotho. (1013 aa)
KLBKlotho beta. (1016 aa)
LCTLactase. (1928 aa)
GLB1Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (653 aa)
GAALysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. Belongs to the glycosyl hydrolase 31 family. (937 aa)
OGAO-GlcNAcase. (916 aa)
GANABGlucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. (966 aa)
SLC3A1Solute carrier family 3 member 1. (685 aa)
SISucrase-isomaltase. (1812 aa)
HEXDHexosaminidase D; Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N- acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates. (475 aa)
CHI3L1Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (391 aa)
AMY2BAlpha-amylase. (511 aa)
GLAAlpha-galactosidase. (439 aa)
MANBABeta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. (879 aa)
GBA3Glucosylceramidase beta 3; Belongs to the glycosyl hydrolase 1 family. (469 aa)
GLB1LGalactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (647 aa)
F1MVE6_BOVINChitin-binding type-2 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (432 aa)
FUCA1Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family. (468 aa)
LOC509761Hyaluronidase. (552 aa)
LOC786974Beta-hexosaminidase. (544 aa)
HEXBBeta-hexosaminidase. (537 aa)
OVGP1Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. (480 aa)
LOC527125Hyaluronidase. (489 aa)
LOC539383Alpha-amylase. (511 aa)
MGAMMaltase-glucoamylase. (2714 aa)
LOC112445747Alpha-amylase. (492 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (669 aa)
HPSE2Uncharacterized protein. (346 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa)
ENSBTAP00000061280Aamy domain-containing protein; Belongs to the glycosyl hydrolase 13 family. (223 aa)
IDUAIduronidase alpha-L-. (690 aa)
GLB1L3Beta-galactosidase. (726 aa)
HYAL3Hyaluronidase. (419 aa)
GBE11,4-alpha-glucan branching enzyme 1. (705 aa)
ENSBTAP00000072907Uncharacterized protein. (631 aa)
CHI3L2Chitinase 3 like 2; Belongs to the glycosyl hydrolase 18 family. (402 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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