STRINGSTRING
SNRNP200 SNRNP200 OTOF OTOF DOCK4 DOCK4 PRKCD PRKCD ENSBTAP00000073808 ENSBTAP00000073808 DOCK3 DOCK3 PLCG2 PLCG2 UNC13D UNC13D C2CD5 C2CD5 SYT11 SYT11 LOC521224 LOC521224 DNAJC6 DNAJC6 PLCE1 PLCE1 ENSBTAP00000070595 ENSBTAP00000070595 SYT14 SYT14 RASAL2 RASAL2 PIK3CA PIK3CA DOCK5 DOCK5 TNS2 TNS2 ENSBTAP00000067574 ENSBTAP00000067574 NEDD4L NEDD4L ITSN2-2 ITSN2-2 PLCH2 PLCH2 PCLO PCLO UNC13B UNC13B PLA2G4E PLA2G4E BCR BCR ESYT2 ESYT2 CAPN5 CAPN5 PIK3CD PIK3CD PIK3CG PIK3CG CPNE5 CPNE5 INPP4B INPP4B SYT2 SYT2 SYTL1 SYTL1 ENSBTAP00000062935 ENSBTAP00000062935 RPGRIP1L RPGRIP1L SYTL2 SYTL2 TNS3 TNS3 INPP4A INPP4A WWC3 WWC3 MCTP1 MCTP1 WWP2 WWP2 SYT9 SYT9 DOCK2 DOCK2 TNS1 TNS1 DOC2A DOC2A PLA2G4B PLA2G4B PLCB2 PLCB2 SMURF2 SMURF2 DAB2IP DAB2IP ABR ABR LOC112449111 LOC112449111 SYTL4 SYTL4 PKN3 PKN3 PLCD1 PLCD1 PIK3C3 PIK3C3 PLA2G4A PLA2G4A PLCH1 PLCH1 C2CD4C C2CD4C MCTP2 MCTP2 CC2D2A CC2D2A C2CD4D C2CD4D RIMS1 RIMS1 C2CD3-2 C2CD3-2 PLCL1 PLCL1 PRKCQ PRKCQ RIMS2 RIMS2 SYT8 SYT8 C2CD6 C2CD6 PLCB1 PLCB1 UNC13A UNC13A PIK3C2A PIK3C2A DOC2G DOC2G ESYT1 ESYT1 RASA2 RASA2 PLCD4 PLCD4 CEP120 CEP120 SMURF1 SMURF1 PIK3C2G PIK3C2G CPNE2 CPNE2 CPNE9 CPNE9 MYOF MYOF HECW2 HECW2 DOCK10 DOCK10 DOC2B DOC2B PLCD3 PLCD3 DYSF DYSF DOCK1 DOCK1 SYT7 SYT7 ITSN1 ITSN1 PKN2 PKN2 C2CD2 C2CD2 HECW1 HECW1 SYNGAP1 SYNGAP1 PRKCB PRKCB CPNE8 CPNE8 ASCC3 ASCC3 RASA3 RASA3 DOCK7 DOCK7 FER1L6 FER1L6 GAK GAK SYT16 SYT16 SYT6 SYT6 RIMS3 RIMS3 SYT15 SYT15 PLCG1 PLCG1 PKN1 PKN1 RASAL1 RASAL1 SEC63 SEC63 DGAT2 DGAT2 CC2D1B CC2D1B WWP1 WWP1 CPNE3 CPNE3 C2CD2L C2CD2L WWC1 WWC1 SYT17 SYT17 BAIAP3 BAIAP3 NEDD4 NEDD4 PRKCG PRKCG PLCZ1 PLCZ1 PLCB4 PLCB4 SYT3 SYT3 PIK3C2B PIK3C2B CPNE7 CPNE7 WWC2 WWC2 RAB11FIP1 RAB11FIP1 RASAL3 RASAL3 ITCH ITCH SYT10 SYT10 CAPN6 CAPN6 PRF1 PRF1 PRKCA PRKCA UNC13C UNC13C SYT13 SYT13 SYT4 SYT4 CPNE6 CPNE6 DOCK8 DOCK8 SYT5 SYT5 PLA2G4D PLA2G4D PRKCH PRKCH SYT12 SYT12 TC2N TC2N RIMS4 RIMS4 SYDE2 SYDE2 FER1L5 FER1L5 RIMS2-2 RIMS2-2 RPH3A RPH3A RPGRIP1 RPGRIP1 SYTL5 SYTL5 PLA2G4F PLA2G4F CC2D1A CC2D1A RAB11FIP5 RAB11FIP5 SYT1 SYT1 DOCK11 DOCK11 PIK3CB PIK3CB CPNE1 CPNE1 RAB11FIP2 RAB11FIP2 AIDA AIDA ESYT3 ESYT3 TOLLIP TOLLIP PTEN PTEN RASA1 RASA1 DOCK6 DOCK6 PLCL2 PLCL2 SYTL3 SYTL3 DOCK9 DOCK9 CPNE4 CPNE4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNRNP200Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa)
OTOFOtoferlin. (1998 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1973 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa)
ENSBTAP00000073808Uncharacterized protein. (481 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2059 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
UNC13DUnc-13 homolog D. (1145 aa)
C2CD5C2 calcium dependent domain containing 5. (1084 aa)
SYT11Synaptotagmin 11. (461 aa)
LOC521224Uncharacterized protein. (790 aa)
DNAJC6Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). (944 aa)
PLCE1Phosphoinositide phospholipase C. (2297 aa)
ENSBTAP00000070595C2 domain-containing protein. (150 aa)
SYT14Synaptotagmin 14. (517 aa)
RASAL2RAS protein activator like 2. (1420 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] (1068 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1962 aa)
TNS2Tensin 2. (1427 aa)
ENSBTAP00000067574Aida_C2 domain-containing protein. (132 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1255 aa)
ITSN2-2Uncharacterized protein. (512 aa)
PLCH2Phosphoinositide phospholipase C. (1400 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5221 aa)
UNC13BUnc-13 homolog B. (1610 aa)
PLA2G4EPhospholipase A2. (836 aa)
BCRBCR activator of RhoGEF and GTPase. (1073 aa)
ESYT2Extended synaptotagmin 2. (898 aa)
CAPN5Calpain 5; Belongs to the peptidase C2 family. (640 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CPNE5Copine 5. (593 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (939 aa)
SYT2Synaptotagmin 2. (519 aa)
SYTL1Synaptotagmin like 1. (640 aa)
ENSBTAP00000062935C2 domain-containing protein. (145 aa)
RPGRIP1LRPGRIP1 like. (1270 aa)
SYTL2Synaptotagmin-like protein 2; May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes. (944 aa)
TNS3Tensin 3. (1595 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (970 aa)
WWC3WWC family member 3. (1107 aa)
MCTP1Uncharacterized protein. (775 aa)
WWP2E3 ubiquitin-protein ligase. (877 aa)
SYT9Synaptotagmin 9. (550 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1868 aa)
TNS1Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. (1883 aa)
DOC2ADouble C2-like domain-containing protein. (401 aa)
PLA2G4BPhospholipase A2. (819 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1198 aa)
SMURF2E3 ubiquitin-protein ligase. (738 aa)
DAB2IPDAB2 interacting protein. (1169 aa)
ABRActive breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] (1195 aa)
LOC112449111Uncharacterized protein. (747 aa)
SYTL4Synaptotagmin like 4. (750 aa)
PKN3Protein kinase N3. (889 aa)
PLCD11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. (781 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (749 aa)
PLCH1Phosphoinositide phospholipase C. (1672 aa)
C2CD4CC2 calcium dependent domain containing 4C. (420 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (916 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
C2CD4DC2 calcium dependent domain containing 4D. (346 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1623 aa)
C2CD3-2C2 domain containing 3 centriole elongation regulator. (1587 aa)
PLCL1Phosphoinositide phospholipase C. (1096 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1137 aa)
SYT8Synaptotagmin 8. (425 aa)
C2CD6C2 calcium dependent domain containing 6. (1847 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
UNC13AUnc-13 homolog A. (1701 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1688 aa)
DOC2GUncharacterized protein. (393 aa)
ESYT1Family with sequence similarity 62 (C2 domain containing), member A. (1106 aa)
RASA2RAS p21 protein activator 2. (848 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (791 aa)
CEP120Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK [...] (987 aa)
SMURF1E3 ubiquitin-protein ligase. (731 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1446 aa)
CPNE2Copine 2. (548 aa)
CPNE9Copine family member 9. (517 aa)
MYOFMyoferlin. (2045 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1571 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PLCD3Phosphoinositide phospholipase C. (815 aa)
DYSFDysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. (2106 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1867 aa)
SYT7Synaptotagmin 7. (643 aa)
ITSN1Intersectin 1. (1716 aa)
PKN2Protein kinase N2. (981 aa)
C2CD2C2 calcium dependent domain containing 2. (697 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1574 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1346 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (673 aa)
CPNE8CPNE8 protein. (564 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. (2201 aa)
RASA3Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4). (834 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2107 aa)
FER1L6Fer-1 like family member 6. (1863 aa)
GAKCyclin G associated kinase. (1268 aa)
SYT16Synaptotagmin 16. (604 aa)
SYT6Synaptotagmin 6. (527 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
SYT15Uncharacterized protein. (408 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa)
PKN1Serine/threonine-protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Se [...] (956 aa)
RASAL1RAS protein activator like 1. (839 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
DGAT2UV radiation resistance associated. (699 aa)
CC2D1BCoiled-coil and C2 domain containing 1B. (856 aa)
WWP1E3 ubiquitin-protein ligase. (921 aa)
CPNE3CPNE3 protein. (533 aa)
C2CD2LC2CD2L protein. (707 aa)
WWC1WW and C2 domain containing 1. (1092 aa)
SYT17Synaptotagmin 17. (505 aa)
BAIAP3BAI1 associated protein 3. (1152 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1321 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (771 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (634 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. (1194 aa)
SYT3Synaptotagmin 3. (591 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
CPNE7Copine 7. (549 aa)
WWC2WW and C2 domain containing 2. (1194 aa)
RAB11FIP1RAB11 family interacting protein 1. (1220 aa)
RASAL3RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway. (1012 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
SYT10Synaptotagmin 10. (523 aa)
CAPN6Calpain 6; Belongs to the peptidase C2 family. (641 aa)
PRF1Perforin 1. (559 aa)
PRKCAProtein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (683 aa)
UNC13CUnc-13 homolog C. (2070 aa)
SYT13Synaptotagmin 13. (426 aa)
SYT4Synaptotagmin 4. (425 aa)
CPNE6Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes; Belongs to the copine family. (557 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2098 aa)
SYT5Synaptotagmin 5. (386 aa)
PLA2G4DPhospholipase A2. (816 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
SYT12Synaptotagmin 12. (421 aa)
TC2NTandem C2 domains, nuclear. (490 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (246 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1446 aa)
FER1L5Fer-1 like family member 5. (2078 aa)
RIMS2-2Regulating synaptic membrane exocytosis 2. (283 aa)
RPH3ARabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity). (704 aa)
RPGRIP1X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells; Belongs to the RPGRIP1 family. (1213 aa)
SYTL5Synaptotagmin like 5. (755 aa)
PLA2G4FPhospholipase A2. (845 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (951 aa)
RAB11FIP5RAB11 family interacting protein 5. (1317 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (442 aa)
DOCK11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2074 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CPNE1Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF- alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium- dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcription [...] (537 aa)
RAB11FIP2RAB11 family interacting protein 2. (511 aa)
AIDAAxin interactor, dorsalization associated. (306 aa)
ESYT3Extended synaptotagmin 3. (870 aa)
TOLLIPToll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (273 aa)
PTENPhosphatase and tensin homolog. (573 aa)
RASA1Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. (1044 aa)
DOCK6Dedicator of cytokinesis 6; Belongs to the DOCK family. (2047 aa)
PLCL2Phosphoinositide phospholipase C. (1118 aa)
SYTL3Synaptotagmin like 3. (611 aa)
DOCK9Dedicator of cytokinesis 9; Belongs to the DOCK family. (2093 aa)
CPNE4Copine 4. (191 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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