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| SNRNP200 | Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa) | ||||
| OTOF | Otoferlin. (1998 aa) | ||||
| DOCK4 | Dedicator of cytokinesis 4; Belongs to the DOCK family. (1973 aa) | ||||
| PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa) | ||||
| ENSBTAP00000073808 | Uncharacterized protein. (481 aa) | ||||
| DOCK3 | Dedicator of cytokinesis 3; Belongs to the DOCK family. (2059 aa) | ||||
| PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa) | ||||
| UNC13D | Unc-13 homolog D. (1145 aa) | ||||
| C2CD5 | C2 calcium dependent domain containing 5. (1084 aa) | ||||
| SYT11 | Synaptotagmin 11. (461 aa) | ||||
| LOC521224 | Uncharacterized protein. (790 aa) | ||||
| DNAJC6 | Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). (944 aa) | ||||
| PLCE1 | Phosphoinositide phospholipase C. (2297 aa) | ||||
| ENSBTAP00000070595 | C2 domain-containing protein. (150 aa) | ||||
| SYT14 | Synaptotagmin 14. (517 aa) | ||||
| RASAL2 | RAS protein activator like 2. (1420 aa) | ||||
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] (1068 aa) | ||||
| DOCK5 | Dedicator of cytokinesis 5; Belongs to the DOCK family. (1962 aa) | ||||
| TNS2 | Tensin 2. (1427 aa) | ||||
| ENSBTAP00000067574 | Aida_C2 domain-containing protein. (132 aa) | ||||
| NEDD4L | NEDD4 like E3 ubiquitin protein ligase. (1255 aa) | ||||
| ITSN2-2 | Uncharacterized protein. (512 aa) | ||||
| PLCH2 | Phosphoinositide phospholipase C. (1400 aa) | ||||
| PCLO | Piccolo presynaptic cytomatrix protein. (5221 aa) | ||||
| UNC13B | Unc-13 homolog B. (1610 aa) | ||||
| PLA2G4E | Phospholipase A2. (836 aa) | ||||
| BCR | BCR activator of RhoGEF and GTPase. (1073 aa) | ||||
| ESYT2 | Extended synaptotagmin 2. (898 aa) | ||||
| CAPN5 | Calpain 5; Belongs to the peptidase C2 family. (640 aa) | ||||
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) | ||||
| PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa) | ||||
| CPNE5 | Copine 5. (593 aa) | ||||
| INPP4B | Inositol polyphosphate-4-phosphatase type II B. (939 aa) | ||||
| SYT2 | Synaptotagmin 2. (519 aa) | ||||
| SYTL1 | Synaptotagmin like 1. (640 aa) | ||||
| ENSBTAP00000062935 | C2 domain-containing protein. (145 aa) | ||||
| RPGRIP1L | RPGRIP1 like. (1270 aa) | ||||
| SYTL2 | Synaptotagmin-like protein 2; May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes. (944 aa) | ||||
| TNS3 | Tensin 3. (1595 aa) | ||||
| INPP4A | Inositol polyphosphate-4-phosphatase type I A. (970 aa) | ||||
| WWC3 | WWC family member 3. (1107 aa) | ||||
| MCTP1 | Uncharacterized protein. (775 aa) | ||||
| WWP2 | E3 ubiquitin-protein ligase. (877 aa) | ||||
| SYT9 | Synaptotagmin 9. (550 aa) | ||||
| DOCK2 | Dedicator of cytokinesis 2; Belongs to the DOCK family. (1868 aa) | ||||
| TNS1 | Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. (1883 aa) | ||||
| DOC2A | Double C2-like domain-containing protein. (401 aa) | ||||
| PLA2G4B | Phospholipase A2. (819 aa) | ||||
| PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1198 aa) | ||||
| SMURF2 | E3 ubiquitin-protein ligase. (738 aa) | ||||
| DAB2IP | DAB2 interacting protein. (1169 aa) | ||||
| ABR | Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] (1195 aa) | ||||
| LOC112449111 | Uncharacterized protein. (747 aa) | ||||
| SYTL4 | Synaptotagmin like 4. (750 aa) | ||||
| PKN3 | Protein kinase N3. (889 aa) | ||||
| PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. (781 aa) | ||||
| PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa) | ||||
| PLA2G4A | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (749 aa) | ||||
| PLCH1 | Phosphoinositide phospholipase C. (1672 aa) | ||||
| C2CD4C | C2 calcium dependent domain containing 4C. (420 aa) | ||||
| MCTP2 | Multiple C2 and transmembrane domain containing 2. (916 aa) | ||||
| CC2D2A | Coiled-coil and C2 domain containing 2A. (1620 aa) | ||||
| C2CD4D | C2 calcium dependent domain containing 4D. (346 aa) | ||||
| RIMS1 | Regulating synaptic membrane exocytosis 1. (1623 aa) | ||||
| C2CD3-2 | C2 domain containing 3 centriole elongation regulator. (1587 aa) | ||||
| PLCL1 | Phosphoinositide phospholipase C. (1096 aa) | ||||
| PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa) | ||||
| RIMS2 | Regulating synaptic membrane exocytosis 2. (1137 aa) | ||||
| SYT8 | Synaptotagmin 8. (425 aa) | ||||
| C2CD6 | C2 calcium dependent domain containing 6. (1847 aa) | ||||
| PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) | ||||
| UNC13A | Unc-13 homolog A. (1701 aa) | ||||
| PIK3C2A | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1688 aa) | ||||
| DOC2G | Uncharacterized protein. (393 aa) | ||||
| ESYT1 | Family with sequence similarity 62 (C2 domain containing), member A. (1106 aa) | ||||
| RASA2 | RAS p21 protein activator 2. (848 aa) | ||||
| PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (791 aa) | ||||
| CEP120 | Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK [...] (987 aa) | ||||
| SMURF1 | E3 ubiquitin-protein ligase. (731 aa) | ||||
| PIK3C2G | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1446 aa) | ||||
| CPNE2 | Copine 2. (548 aa) | ||||
| CPNE9 | Copine family member 9. (517 aa) | ||||
| MYOF | Myoferlin. (2045 aa) | ||||
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1571 aa) | ||||
| DOCK10 | Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa) | ||||
| DOC2B | Double C2-like domain-containing protein. (412 aa) | ||||
| PLCD3 | Phosphoinositide phospholipase C. (815 aa) | ||||
| DYSF | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. (2106 aa) | ||||
| DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1867 aa) | ||||
| SYT7 | Synaptotagmin 7. (643 aa) | ||||
| ITSN1 | Intersectin 1. (1716 aa) | ||||
| PKN2 | Protein kinase N2. (981 aa) | ||||
| C2CD2 | C2 calcium dependent domain containing 2. (697 aa) | ||||
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1574 aa) | ||||
| SYNGAP1 | Synaptic Ras GTPase activating protein 1. (1346 aa) | ||||
| PRKCB | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (673 aa) | ||||
| CPNE8 | CPNE8 protein. (564 aa) | ||||
| ASCC3 | Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. (2201 aa) | ||||
| RASA3 | Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4). (834 aa) | ||||
| DOCK7 | Dedicator of cytokinesis 7; Belongs to the DOCK family. (2107 aa) | ||||
| FER1L6 | Fer-1 like family member 6. (1863 aa) | ||||
| GAK | Cyclin G associated kinase. (1268 aa) | ||||
| SYT16 | Synaptotagmin 16. (604 aa) | ||||
| SYT6 | Synaptotagmin 6. (527 aa) | ||||
| RIMS3 | Regulating synaptic membrane exocytosis 3. (308 aa) | ||||
| SYT15 | Uncharacterized protein. (408 aa) | ||||
| PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa) | ||||
| PKN1 | Serine/threonine-protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Se [...] (956 aa) | ||||
| RASAL1 | RAS protein activator like 1. (839 aa) | ||||
| SEC63 | SEC63 homolog, protein translocation regulator. (760 aa) | ||||
| DGAT2 | UV radiation resistance associated. (699 aa) | ||||
| CC2D1B | Coiled-coil and C2 domain containing 1B. (856 aa) | ||||
| WWP1 | E3 ubiquitin-protein ligase. (921 aa) | ||||
| CPNE3 | CPNE3 protein. (533 aa) | ||||
| C2CD2L | C2CD2L protein. (707 aa) | ||||
| WWC1 | WW and C2 domain containing 1. (1092 aa) | ||||
| SYT17 | Synaptotagmin 17. (505 aa) | ||||
| BAIAP3 | BAI1 associated protein 3. (1152 aa) | ||||
| NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1321 aa) | ||||
| PRKCG | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (771 aa) | ||||
| PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (634 aa) | ||||
| PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. (1194 aa) | ||||
| SYT3 | Synaptotagmin 3. (591 aa) | ||||
| PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) | ||||
| CPNE7 | Copine 7. (549 aa) | ||||
| WWC2 | WW and C2 domain containing 2. (1194 aa) | ||||
| RAB11FIP1 | RAB11 family interacting protein 1. (1220 aa) | ||||
| RASAL3 | RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway. (1012 aa) | ||||
| ITCH | E3 ubiquitin-protein ligase. (862 aa) | ||||
| SYT10 | Synaptotagmin 10. (523 aa) | ||||
| CAPN6 | Calpain 6; Belongs to the peptidase C2 family. (641 aa) | ||||
| PRF1 | Perforin 1. (559 aa) | ||||
| PRKCA | Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (683 aa) | ||||
| UNC13C | Unc-13 homolog C. (2070 aa) | ||||
| SYT13 | Synaptotagmin 13. (426 aa) | ||||
| SYT4 | Synaptotagmin 4. (425 aa) | ||||
| CPNE6 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes; Belongs to the copine family. (557 aa) | ||||
| DOCK8 | Dedicator of cytokinesis 8; Belongs to the DOCK family. (2098 aa) | ||||
| SYT5 | Synaptotagmin 5. (386 aa) | ||||
| PLA2G4D | Phospholipase A2. (816 aa) | ||||
| PRKCH | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa) | ||||
| SYT12 | Synaptotagmin 12. (421 aa) | ||||
| TC2N | Tandem C2 domains, nuclear. (490 aa) | ||||
| RIMS4 | Regulating synaptic membrane exocytosis 4. (246 aa) | ||||
| SYDE2 | Synapse defective Rho GTPase homolog 2. (1446 aa) | ||||
| FER1L5 | Fer-1 like family member 5. (2078 aa) | ||||
| RIMS2-2 | Regulating synaptic membrane exocytosis 2. (283 aa) | ||||
| RPH3A | Rabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity). (704 aa) | ||||
| RPGRIP1 | X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells; Belongs to the RPGRIP1 family. (1213 aa) | ||||
| SYTL5 | Synaptotagmin like 5. (755 aa) | ||||
| PLA2G4F | Phospholipase A2. (845 aa) | ||||
| CC2D1A | Coiled-coil and C2 domain containing 1A. (951 aa) | ||||
| RAB11FIP5 | RAB11 family interacting protein 5. (1317 aa) | ||||
| SYT1 | Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (442 aa) | ||||
| DOCK11 | Dedicator of cytokinesis 11; Belongs to the DOCK family. (2074 aa) | ||||
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) | ||||
| CPNE1 | Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF- alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium- dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcription [...] (537 aa) | ||||
| RAB11FIP2 | RAB11 family interacting protein 2. (511 aa) | ||||
| AIDA | Axin interactor, dorsalization associated. (306 aa) | ||||
| ESYT3 | Extended synaptotagmin 3. (870 aa) | ||||
| TOLLIP | Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (273 aa) | ||||
| PTEN | Phosphatase and tensin homolog. (573 aa) | ||||
| RASA1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. (1044 aa) | ||||
| DOCK6 | Dedicator of cytokinesis 6; Belongs to the DOCK family. (2047 aa) | ||||
| PLCL2 | Phosphoinositide phospholipase C. (1118 aa) | ||||
| SYTL3 | Synaptotagmin like 3. (611 aa) | ||||
| DOCK9 | Dedicator of cytokinesis 9; Belongs to the DOCK family. (2093 aa) | ||||
| CPNE4 | Copine 4. (191 aa) | ||||