STRINGSTRING
DENND5B DENND5B RAB35 RAB35 DENND2A DENND2A DENND4B DENND4B IGF2R IGF2R RAB17 RAB17 DENND1C DENND1C DENND5A DENND5A DENND2C DENND2C AP3D1 AP3D1 LAMP1 LAMP1 RAB27B RAB27B DENND1A DENND1A DENND4C DENND4C RHOBTB3 RHOBTB3 RAB21 RAB21 RCC1 RCC1 CLTC CLTC DENND3 DENND3 DENND1B DENND1B TFRC TFRC RAB3GAP1 RAB3GAP1 DENND4A DENND4A RAB13 RAB13 RAB9B RAB9B DENND2D DENND2D RAB22A RAB22A LOC781001 LOC781001 RAB10 RAB10 RIC1 RIC1 AVL9 AVL9 RAB28 RAB28 CCZ1 CCZ1 RABGEF1 RABGEF1 DENND2B DENND2B RAB9A RAB9A RAB8B RAB8B RAB27A RAB27A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DENND5BDENN domain containing 5B. (1274 aa)
RAB35RAB35, member RAS oncogene family. (201 aa)
DENND2ADENN domain containing 2A. (1022 aa)
DENND4BDENN domain containing 4B. (1501 aa)
IGF2RCation-independent mannose-6-phosphate receptor; Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2; Belongs to the MRL1/IGF2R family. (2499 aa)
RAB17RAB17, member RAS oncogene family. (213 aa)
DENND1CDENN domain containing 1C. (798 aa)
DENND5ADENN domain containing 5A. (1290 aa)
DENND2CDENN domain containing 2C. (936 aa)
AP3D1AP-3 complex subunit delta-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T- cell and NK cell degranulation. In concert with the BLOC-1 complex, AP- 3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Belongs to the adaptor complexes large subunit [...] (1224 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. (409 aa)
RAB27BRas-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes. (218 aa)
DENND1ADENN domain containing 1A. (1049 aa)
DENND4CDENN domain containing 4C. (1964 aa)
RHOBTB3Rho related BTB domain containing 3. (982 aa)
RAB21Ras-related protein Rab-21; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 en [...] (222 aa)
RCC1Regulator of chromosome condensation 1. (444 aa)
CLTCClathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Belongs to the clathrin heavy chain [...] (1675 aa)
DENND3DENN domain containing 3. (1330 aa)
DENND1BDENN domain containing 1B. (760 aa)
TFRCTransferrin receptor. (769 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (982 aa)
DENND4ADENN domain containing 4A. (1906 aa)
RAB13Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] (203 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
DENND2DDENN domain containing 2D. (478 aa)
RAB22ARAB22A, member RAS oncogene family. (194 aa)
LOC781001RAB21, member RAS oncogene family. (214 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1422 aa)
AVL9AVL9 cell migration associated. (646 aa)
RAB28Ras-related protein Rab-28. (221 aa)
CCZ1Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. (480 aa)
RABGEF1Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. (491 aa)
DENND2BSuppression of tumorigenicity 5. (1153 aa)
RAB9ARAB9A, member RAS oncogene family. (203 aa)
RAB8BRas-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). (207 aa)
RAB27ARAB27A protein. (221 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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