| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD44 | CDH1 | ENSBTAP00000048925 | ENSBTAP00000073179 | CD44 antigen. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.887 |
| CD44 | HAS2 | ENSBTAP00000048925 | ENSBTAP00000026503 | CD44 antigen. | Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...] | 0.842 |
| CD44 | SRC | ENSBTAP00000048925 | ENSBTAP00000011767 | CD44 antigen. | Tyrosine-protein kinase. | 0.809 |
| CD44 | WASL | ENSBTAP00000048925 | ENSBTAP00000006094 | CD44 antigen. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.525 |
| CDH1 | CD44 | ENSBTAP00000073179 | ENSBTAP00000048925 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | CD44 antigen. | 0.887 |
| CDH1 | CTTN | ENSBTAP00000073179 | ENSBTAP00000007976 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Cortactin. | 0.733 |
| CDH1 | HCLS1 | ENSBTAP00000073179 | ENSBTAP00000001338 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Hematopoietic cell-specific Lyn substrate 1. | 0.733 |
| CDH1 | SRC | ENSBTAP00000073179 | ENSBTAP00000011767 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Tyrosine-protein kinase. | 0.908 |
| CDH1 | WASL | ENSBTAP00000073179 | ENSBTAP00000006094 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.468 |
| CTTN | CDH1 | ENSBTAP00000007976 | ENSBTAP00000073179 | Cortactin. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.733 |
| CTTN | HCLS1 | ENSBTAP00000007976 | ENSBTAP00000001338 | Cortactin. | Hematopoietic cell-specific Lyn substrate 1. | 0.934 |
| CTTN | SRC | ENSBTAP00000007976 | ENSBTAP00000011767 | Cortactin. | Tyrosine-protein kinase. | 0.990 |
| CTTN | WASL | ENSBTAP00000007976 | ENSBTAP00000006094 | Cortactin. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.998 |
| HAS2 | CD44 | ENSBTAP00000026503 | ENSBTAP00000048925 | Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...] | CD44 antigen. | 0.842 |
| HCLS1 | CDH1 | ENSBTAP00000001338 | ENSBTAP00000073179 | Hematopoietic cell-specific Lyn substrate 1. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.733 |
| HCLS1 | CTTN | ENSBTAP00000001338 | ENSBTAP00000007976 | Hematopoietic cell-specific Lyn substrate 1. | Cortactin. | 0.934 |
| HCLS1 | SRC | ENSBTAP00000001338 | ENSBTAP00000011767 | Hematopoietic cell-specific Lyn substrate 1. | Tyrosine-protein kinase. | 0.988 |
| HCLS1 | WASL | ENSBTAP00000001338 | ENSBTAP00000006094 | Hematopoietic cell-specific Lyn substrate 1. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.998 |
| SRC | CD44 | ENSBTAP00000011767 | ENSBTAP00000048925 | Tyrosine-protein kinase. | CD44 antigen. | 0.809 |
| SRC | CDH1 | ENSBTAP00000011767 | ENSBTAP00000073179 | Tyrosine-protein kinase. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.908 |