STRINGSTRING
ACTA2 ACTA2 TRPS1 TRPS1 EN1 EN1 MYF5 MYF5 AXIN2 AXIN2 ABCC9 ABCC9 LHX9 LHX9 PPARG PPARG VCAM1 VCAM1 LOC534578 LOC534578 DACT2 DACT2 BGN BGN MPZ MPZ NKD2 NKD2 DPP4 DPP4 HIC1 HIC1 HMGA2 HMGA2 HMCN1 HMCN1 KRT1 KRT1 POSTN POSTN PTCH1 PTCH1 FZD2 FZD2 ADRA2A ADRA2A NR4A1 NR4A1 SNAI1 SNAI1 SMTN SMTN SOX11 SOX11 LEF1 LEF1 CRABP2 CRABP2 COL15A1 COL15A1 SOX6 SOX6 MYL9 MYL9 PDGFRB PDGFRB FBN1 FBN1 TCF7L2 TCF7L2 RSPO1 RSPO1 DLK1 DLK1 CXCL12 CXCL12 MYH11 MYH11 CDKN1C CDKN1C PECAM1 PECAM1 PDGFRA PDGFRA GLB1L3 GLB1L3 CEBPD CEBPD IFITM1 IFITM1 FBLN1 FBLN1 CEBPB CEBPB SOX9 SOX9 CD34 CD34 ITGA8 ITGA8 SOX5 SOX5 PDLIM3 PDLIM3 MFAP5 MFAP5 IRX1 IRX1 MYH3 MYH3 PI16 PI16 KCNJ8 KCNJ8 KIT KIT COL10A1 COL10A1 LOC112444847 LOC112444847 DKK3 DKK3 SOX17 SOX17 SEMA3C SEMA3C PAX1 PAX1 TAGLN TAGLN RSPO3 RSPO3 CDKN1A CDKN1A SCX SCX PAX3 PAX3 ALDH1A2 ALDH1A2 MYOCD MYOCD PODXL PODXL CNN1 CNN1 SOX18 SOX18 GLB1L2 GLB1L2 PODN PODN CRABP1 CRABP1 CLDN1 CLDN1 COL2A1 COL2A1 BIRC5 BIRC5 ITGA5 ITGA5 MSX2 MSX2 WNT6 WNT6 RARS1 RARS1 AANAT AANAT PAX7 PAX7 GLB1 GLB1 PLIN1 PLIN1 SFRP4 SFRP4 MYL12A MYL12A KRT5 KRT5 ACAN ACAN C1QTNF3 C1QTNF3 CCND1 CCND1 CLEC3B CLEC3B CCNB1 CCNB1 THY1 THY1 WNT5A WNT5A CD200 CD200 TNMD TNMD COL11A1 COL11A1 LRIG1 LRIG1 SOX10 SOX10 COL4A1 COL4A1 CNMD CNMD KRT14 KRT14 THBS4 THBS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
TRPS1Transcriptional repressor GATA binding 1. (1293 aa)
EN1Homeobox protein engrailed-like. (400 aa)
MYF5Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (255 aa)
AXIN2Axin 2. (846 aa)
ABCC9ATP binding cassette subfamily C member 9. (1546 aa)
LHX9LIM/homeobox protein Lhx9; Involved in gonadal development. (378 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
VCAM1Vascular cell adhesion molecule-1 7D variant. (739 aa)
LOC534578VCAM1 protein. (740 aa)
DACT2Dishevelled binding antagonist of beta catenin 2. (729 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (369 aa)
MPZMyelin protein P0; Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. (248 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (405 aa)
DPP4Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (765 aa)
HIC1HIC ZBTB transcriptional repressor 1. (865 aa)
HMGA2High mobility group AT-hook 2. (109 aa)
HMCN1Hemicentin 1. (5635 aa)
KRT1Keratin 1; Belongs to the intermediate filament family. (606 aa)
POSTNPeriostin. (836 aa)
PTCH1SSD domain-containing protein. (1453 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily. (468 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (By similarity). (598 aa)
SNAI1Snail family transcriptional repressor 1. (267 aa)
SMTNSmoothelin. (912 aa)
SOX11Transcription factor SOX. (451 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CRABP2Cellular retinoic acid-binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity). (171 aa)
COL15A1Collagen type XV alpha 1 chain. (1398 aa)
SOX6SRY-box 6. (858 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1107 aa)
FBN1Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2990 aa)
TCF7L2Transcription factor 7 like 2. (621 aa)
RSPO1R-spondin 1. (262 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1972 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (301 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-689 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (717 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
GLB1L3Beta-galactosidase. (726 aa)
CEBPDCCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB. (256 aa)
IFITM1Uncharacterized protein. (185 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa)
CEBPBCCAAT/enhancer-binding protein beta; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipo [...] (348 aa)
SOX9SRY-box transcription factor 9. (524 aa)
CD34CD34 molecule. (386 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1020 aa)
SOX5SRY-box 5. (750 aa)
PDLIM3PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells. (364 aa)
MFAP5Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity). (249 aa)
IRX1Iroquois homeobox 1. (476 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
PI16Peptidase inhibitor 16; May inhibit cardiomyocyte growth. Belongs to the CRISP family. (464 aa)
KCNJ8Potassium inwardly-rectifying channel, subfamily J, member 8. (424 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (977 aa)
COL10A1Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. (674 aa)
LOC112444847Uncharacterized protein. (130 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
SOX17SRY-box 17. (410 aa)
SEMA3CSemaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). (751 aa)
PAX1Paired box 1. (452 aa)
TAGLNTransgelin; Actin cross-linking/gelling protein. (201 aa)
RSPO3R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non- canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts [...] (273 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
SCXScleraxis bHLH transcription factor. (203 aa)
PAX3Paired box 3. (484 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
MYOCDMyocardin. (982 aa)
PODXLPodocalyxin like. (509 aa)
CNN1Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). (297 aa)
SOX18SRY (Sex determining region Y)-box 18. (389 aa)
GLB1L2Beta-galactosidase. (635 aa)
PODNPodocan. (644 aa)
CRABP1Cellular retinoic acid-binding protein 1; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. (137 aa)
CLDN1Claudin-1; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. [...] (211 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1487 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
ITGA5Integrin alpha-5 heavy chain; Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD [...] (1164 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). (267 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RARS1Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. (660 aa)
AANATSerotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. Belongs to the acetyltransferase family. AANAT subfamily. (207 aa)
PAX7Paired box 7. (505 aa)
GLB1Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (653 aa)
PLIN1Perilipin; Belongs to the perilipin family. (516 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
MYL12AMyosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa)
KRT5Keratin, type II cytoskeletal 5. (597 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2366 aa)
C1QTNF3C1QTNF3 protein. (246 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (428 aa)
CLEC3BTetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity). (282 aa)
CCNB1G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (427 aa)
THY1Thy-1 cell surface antigen. (161 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CD200CD200 molecule. (267 aa)
TNMDTenomodulin. (318 aa)
COL11A1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1817 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1090 aa)
SOX10SRY-box transcription factor 10. (469 aa)
COL4A1Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1669 aa)
CNMDLeukocyte cell-derived chemotaxin 1; Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity); Belongs to the chondrom [...] (335 aa)
KRT14Keratin, type I cytoskeletal 14; Belongs to the intermediate filament family. (515 aa)
THBS4Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] (961 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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