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HAO2 HAO2 PEX3 PEX3 PRDX1 PRDX1 HACL1 HACL1 SCP2 SCP2 PEX2 PEX2 ACOX2 ACOX2 MLYCD MLYCD MVK MVK PEX13 PEX13 PEX6 PEX6 AGXT AGXT PEX11A PEX11A SLC25A17 SLC25A17 SOD2 SOD2 PECR PECR NOS2 NOS2 HSD17B4 HSD17B4 PXMP2 PXMP2 PEX19 PEX19 PHYH PHYH PIPOX PIPOX PEX11B PEX11B PRDX5 PRDX5 FAR1 FAR1 GSTK1 GSTK1 FAR2 FAR2 PEX5L PEX5L IDH2 IDH2 ABCD4 ABCD4 HMGCLL1 HMGCLL1 EPHX2 EPHX2 PEX7 PEX7 ACSL3 ACSL3 DHRS4 DHRS4 PMVK PMVK MPV17 MPV17 ACAA1 ACAA1 DAO DAO PEX11G PEX11G PEX12 PEX12 IDH1 IDH1 ABCD1 ABCD1 CROT CROT AMACR AMACR HMGCL HMGCL SOD1 SOD1 NUDT7 NUDT7 ABCD3 ABCD3 PEX1 PEX1 LOC530653 LOC530653 NUDT12 NUDT12 ACOX3 ACOX3 NUDT19 NUDT19 PAOX PAOX ABCD2 ABCD2 ACSL4 ACSL4 PXMP4 PXMP4 EHHADH EHHADH ACSL5 ACSL5 LOC100300115 LOC100300115 PEX14 PEX14 ECH1 ECH1 CRAT CRAT XDH XDH ECI2 ECI2 ACSL1 ACSL1 ACSL6 ACSL6 GNPAT GNPAT SLC27A2 SLC27A2 AGPS AGPS ACOX1 ACOX1 PEX5 PEX5 DDO DDO PEX26 PEX26
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HAO2Hydroxyacid oxidase 2; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (353 aa)
PEX3Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity). (373 aa)
PRDX1Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] (199 aa)
HACL12-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (581 aa)
SCP2Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. (543 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (682 aa)
MLYCDMLYCD protein. (499 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
PEX13Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). (403 aa)
PEX6Peroxisomal biogenesis factor 6. (980 aa)
AGXTSerine--pyruvate aminotransferase. (414 aa)
PEX11APeroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. (247 aa)
SLC25A17Solute carrier family 25 (Mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (492 aa)
PECRPeroxisomal trans-2-enoyl-CoA reductase. (305 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1156 aa)
HSD17B4Hydroxysteroid (17-beta) dehydrogenase 4. (736 aa)
PXMP2Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. (294 aa)
PEX19Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). (299 aa)
PHYHPhytanoyl-CoA dioxygenase, peroxisomal; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. (337 aa)
PIPOXPeroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. Belongs to the MSOX/MTOX family. (392 aa)
PEX11BPeroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. (258 aa)
PRDX5Peroxiredoxin-5, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. (219 aa)
FAR1Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
GSTK1Glutathione S-transferase kappa. (226 aa)
FAR2Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates. (515 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (603 aa)
IDH2Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
ABCD4ATP binding cassette subfamily D member 4. (606 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (340 aa)
EPHX2Epoxide hydrolase 2. (555 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
DHRS4Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). (279 aa)
PMVKPhosphomevalonate kinase. (192 aa)
MPV17Protein Mpv17; Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (By similarity). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity); Belongs to the peroxisomal membrane protein PXMP2/4 family. (178 aa)
ACAA1Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
DAOD-amino acid oxidase. (347 aa)
PEX11GPeroxisomal biogenesis factor 11 gamma. (240 aa)
PEX12Peroxisome assembly protein 12; Required for protein import into peroxisomes. (359 aa)
IDH1Isocitrate dehydrogenase [NADP] cytoplasmic; May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. (414 aa)
ABCD1ATP-binding cassette, sub-family D (ALD), member 1. (737 aa)
CROTPeroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate; Belongs to the carnitine/choline acetyltransferase family. (616 aa)
AMACRAlpha-methylacyl-CoA racemase. (382 aa)
HMGCLHydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. (325 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
NUDT7Nudix hydrolase 7. (238 aa)
ABCD3ATP binding cassette subfamily D member 3. (656 aa)
PEX1Peroxisomal biogenesis factor 1. (1281 aa)
LOC530653Uncharacterized protein. (484 aa)
NUDT12Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. (444 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
NUDT19Nudix hydrolase 19. (381 aa)
PAOXPeroxisomal N(1)-acetyl-spermine/spermidine oxidase; Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration. (529 aa)
ABCD2ATP binding cassette subfamily D member 2. (741 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (734 aa)
PXMP4Peroxisomal membrane protein 4; Belongs to the peroxisomal membrane protein PXMP2/4 family. (212 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
ACSL5Acyl-CoA synthetase long-chain family member 5. (683 aa)
LOC100300115Uncharacterized protein. (333 aa)
PEX14Peroxisomal biogenesis factor 14. (389 aa)
ECH1Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (326 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
XDHXanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. (1350 aa)
ECI2Enoyl-CoA delta isomerase 2. (454 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (728 aa)
ACSL6Acyl-CoA synthetase long chain family member 6. (722 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (680 aa)
SLC27A2Solute carrier family 27 member 2. (633 aa)
AGPSAlkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (658 aa)
ACOX1Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (660 aa)
PEX5Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (640 aa)
DDOD-aspartate oxidase; Belongs to the DAMOX/DASOX family. (341 aa)
PEX26Peroxisomal biogenesis factor 26. (300 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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