STRINGSTRING
PRKAA1 PRKAA1 PER2 PER2 PER1 PER1 CREB1 CREB1 PRKAB1 PRKAB1 BTRC BTRC BHLHE40 BHLHE40 PRKAG3 PRKAG3 PRKAA2 PRKAA2 FBXL3 FBXL3 NPAS2 NPAS2 CSNK1E CSNK1E SKP1 SKP1 BHLHE41 BHLHE41 CRY1 CRY1 PRKAG1 PRKAG1 RORB RORB PRKAG2 PRKAG2 ARNTL ARNTL PER3 PER3 CSNK1D CSNK1D LOC780968 LOC780968 CUL1 CUL1 NR1D1 NR1D1 FBXW11 FBXW11 RORC RORC RORA RORA CLOCK CLOCK PRKAB2 PRKAB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PER2PAS domain-containing protein. (1311 aa)
PER1Period circadian regulator 1. (1284 aa)
CREB1Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. (327 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] (270 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (569 aa)
BHLHE40Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] (412 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (497 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
FBXL3F-box and leucine rich repeat protein 3. (321 aa)
NPAS2Neuronal PAS domain protein 2. (827 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (466 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
BHLHE41Basic helix-loop-helix family, member e41. (374 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (349 aa)
RORBRAR related orphan receptor B. (470 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (565 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
PER3PAS domain-containing protein. (374 aa)
CSNK1DCasein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (447 aa)
LOC780968RING-type domain-containing protein. (108 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] (630 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
RORCRAR related orphan receptor C. (611 aa)
RORARAR related orphan receptor A. (527 aa)
CLOCKClock circadian regulator. (845 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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