(105 nodes) Synaptic vesicle cycle network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYT8	Synaptotagmin 8. (431 aa)
	SNAP91	Synaptosome associated protein 91. (900 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	ITSN1	Intersectin 1. (1716 aa)
	SNCB	Beta-synuclein; Belongs to the synuclein family. (142 aa)
	CADPS2	Calcium dependent secretion activator 2. (1262 aa)
	SYT2	Synaptotagmin 2. (417 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)
	AP3D1	Adaptor related protein complex 3 subunit delta 1. (1207 aa)
	GIT2	GIT ArfGAP 2. (759 aa)
	SNAP47	Synaptosome associated protein 47. (420 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
	ENSCHIP00000030683	Uncharacterized protein. (66 aa)
	RAB5A	Uncharacterized protein. (215 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	STX2	Syntaxin 2; Belongs to the syntaxin family. (288 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	CPLX2	Complexin 2. (134 aa)
	SYNPR	Synaptoporin. (265 aa)
	NLGN3	Neuroligin 3. (789 aa)
	ACTG1	Actin gamma 1. (376 aa)
	NLGN1	Neuroligin 1. (509 aa)
	SYT1	Synaptotagmin 1. (441 aa)
	DNAJC6	DnaJ heat shock protein family (Hsp40) member C6. (944 aa)
	SH3GL1	SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
	SNCG	Gamma-synuclein; Belongs to the synuclein family. (128 aa)
	SYP	Synaptophysin. (313 aa)
	CPLX3	Complexin 3. (158 aa)
	CANX	Calnexin. (593 aa)
	ERC2	ELKS/RAB6-interacting/CAST family member 2. (969 aa)
	STX19	Syntaxin 19; Belongs to the syntaxin family. (294 aa)
	SYT5	Synaptotagmin 5. (386 aa)
	SYNJ1	Synaptojanin 1. (1537 aa)
	STX11	Syntaxin 11; Belongs to the syntaxin family. (287 aa)
	LOC108636029	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	RAB3A	RAB3A, member RAS oncogene family. (228 aa)
	NLGN4X	COesterase domain-containing protein. (815 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1194 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (308 aa)
	PACSIN1	Protein kinase C and casein kinase substrate in neurons 1. (444 aa)
	DOC2B	Double C2-like domain-containing protein. (412 aa)
	ENSCHIP00000005548	Uncharacterized protein. (126 aa)
	SYN1	Synapsin I. (708 aa)
	DNM3	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (859 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	SLC32A1	Solute carrier family 32 member 1. (526 aa)
	UNC13A	Unc-13 homolog A. (1730 aa)
	ENSCHIP00000007454	Uncharacterized protein. (116 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1678 aa)
	SYNJ2	Synaptojanin 2. (1484 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	STON2	Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (906 aa)
	FCHO2	FCH domain only 2. (811 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (140 aa)
	ENSCHIP00000009674	2-Hacid_dh domain-containing protein. (402 aa)
	NOSTRIN	Nitric oxide synthase trafficking. (506 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (5197 aa)
	UNC13B	Unc-13 homolog B. (1612 aa)
	UNC13C	Uncharacterized protein. (1170 aa)
	STON1	Stonin-1; May be involved in the endocytic machinery. (781 aa)
	ACTB	Uncharacterized protein. (375 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (296 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1441 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	CPLX4	Complexin 4. (160 aa)
	SLC18A1	Solute carrier family 18 member A1. (538 aa)
	PRRT2	Proline rich transmembrane protein 2. (339 aa)
	NLGN2	Neuroligin 2. (817 aa)
	LRRC1	Leucine rich repeat containing 1. (517 aa)
	ENSCHIP00000023252	Uncharacterized protein. (130 aa)
	AMPH	Amphiphysin. (684 aa)
	SYNDIG1	Synapse differentiation inducing 1. (258 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	GIT1	GIT ArfGAP 1. (738 aa)
	CTBP2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (459 aa)
	OPHN1	Oligophrenin 1. (436 aa)
	CLCN3	Chloride channel protein. (866 aa)
	SCRIB	Scribble planar cell polarity protein. (1582 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
	TBC1D24	Uncharacterized protein. (559 aa)
	SNAP29	Synaptosome associated protein 29. (258 aa)
	OTOF	Otoferlin. (2013 aa)
	DNM1	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (863 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (774 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	DENND1A	DENN domain containing 1A. (1024 aa)
	SYT9	Synaptotagmin 9. (500 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	SV2A	Synaptic vesicle glycoprotein 2A. (742 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	SLC17A8	Solute carrier family 17 member 8. (589 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (289 aa)
	CADPS-2	Uncharacterized protein. (153 aa)
	SLC17A7	Solute carrier family 17 member 7. (560 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (288 aa)
	ENSCHIP00000015518	Uncharacterized protein; Belongs to the heat shock protein 70 family. (520 aa)
	SH3GL3	SH3 domain containing GRB2 like 3, endophilin A3. (347 aa)
	ENSCHIP00000015255	ENTH domain-containing protein. (414 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (208 aa)
	BTBD8	BTB domain containing 8. (1350 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (701 aa)
	CADPS	Uncharacterized protein. (771 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSCHIP00000011080	ENSCHIP00000032903	Uncharacterized protein.	Actin gamma 1.	0.487
ACTB	BRAF	ENSCHIP00000011080	ENSCHIP00000019379	Uncharacterized protein.	B-Raf proto-oncogene, serine/threonine kinase.	0.746
ACTB	CANX	ENSCHIP00000011080	ENSCHIP00000000791	Uncharacterized protein.	Calnexin.	0.805
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	DNM1	ENSCHIP00000011080	ENSCHIP00000019385	Uncharacterized protein.	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.422
ACTB	DNM2	ENSCHIP00000011080	ENSCHIP00000031761	Uncharacterized protein.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.478
ACTB	HSPA8	ENSCHIP00000011080	ENSCHIP00000017002	Uncharacterized protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.578
ACTB	ITSN1	ENSCHIP00000011080	ENSCHIP00000026127	Uncharacterized protein.	Intersectin 1.	0.546
ACTB	LOC108636029	ENSCHIP00000011080	ENSCHIP00000003345	Uncharacterized protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.452
ACTB	PSEN1	ENSCHIP00000011080	ENSCHIP00000030611	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.700
ACTB	RAP1A	ENSCHIP00000011080	ENSCHIP00000018221	Uncharacterized protein.	RAP1A, member of RAS oncogene family.	0.459
ACTB	SNAP25	ENSCHIP00000011080	ENSCHIP00000022303	Uncharacterized protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.627
ACTB	SNCA	ENSCHIP00000011080	ENSCHIP00000009503	Uncharacterized protein.	Alpha-synuclein; Belongs to the synuclein family.	0.766
ACTB	SYN1	ENSCHIP00000011080	ENSCHIP00000006055	Uncharacterized protein.	Synapsin I.	0.593
ACTB	SYP	ENSCHIP00000011080	ENSCHIP00000000611	Uncharacterized protein.	Synaptophysin.	0.795
ACTB	SYT1	ENSCHIP00000011080	ENSCHIP00000033749	Uncharacterized protein.	Synaptotagmin 1.	0.477
ACTB	VAMP2	ENSCHIP00000011080	ENSCHIP00000006673	Uncharacterized protein.	V-SNARE coiled-coil homology domain-containing protein.	0.523
ACTG1	ACTB	ENSCHIP00000032903	ENSCHIP00000011080	Actin gamma 1.	Uncharacterized protein.	0.487
ACTG1	CANX	ENSCHIP00000032903	ENSCHIP00000000791	Actin gamma 1.	Calnexin.	0.436
ACTG1	HSPA8	ENSCHIP00000032903	ENSCHIP00000017002	Actin gamma 1.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.490