13 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKG2	cGMP-dependent protein kinase. (762 aa)
	GCHFR	GTP cyclohydrolase I feedback regulator. (84 aa)
	GCH1	GTP cyclohydrolase 1. (254 aa)
	LOC105614854	Uncharacterized protein; Belongs to the calmodulin family. (145 aa)
	ENSOARP00000005690	annotation not available (148 aa)
	HSP90AA1	Heat shock protein alpha. (733 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (150 aa)
	NOS3	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
	W5PG97_SHEEP	Uncharacterized protein. (143 aa)
	CALM3	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
	W5PNS7_SHEEP	Uncharacterized protein. (61 aa)
	SPR	Sepiapterin reductase. (267 aa)
	PTS	6-pyruvoyltetrahydropterin synthase. (144 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	HSP90AA1	ENSOARP00000003726	ENSOARP00000004171	Calmodulin 1; Belongs to the calmodulin family.	Heat shock protein alpha.	0.500
CALM1	NOS3	ENSOARP00000003726	ENSOARP00000002091	Calmodulin 1; Belongs to the calmodulin family.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.492
CALM3	ENSOARP00000005690	ENSOARP00000011414	ENSOARP00000005690	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	annotation not available	0.847
CALM3	HSP90AA1	ENSOARP00000011414	ENSOARP00000004171	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Heat shock protein alpha.	0.881
CALM3	LOC105614854	ENSOARP00000011414	ENSOARP00000022802	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Uncharacterized protein; Belongs to the calmodulin family.	0.949
CALM3	NOS3	ENSOARP00000011414	ENSOARP00000002091	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.865
CALM3	PRKG2	ENSOARP00000011414	ENSOARP00000020488	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	cGMP-dependent protein kinase.	0.414
ENSOARP00000005690	CALM3	ENSOARP00000005690	ENSOARP00000011414	annotation not available	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.847
ENSOARP00000005690	NOS3	ENSOARP00000005690	ENSOARP00000002091	annotation not available	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.704
GCH1	GCHFR	ENSOARP00000022652	ENSOARP00000021765	GTP cyclohydrolase 1.	GTP cyclohydrolase I feedback regulator.	0.983
GCH1	PTS	ENSOARP00000022652	ENSOARP00000017775	GTP cyclohydrolase 1.	6-pyruvoyltetrahydropterin synthase.	0.899
GCH1	SPR	ENSOARP00000022652	ENSOARP00000012467	GTP cyclohydrolase 1.	Sepiapterin reductase.	0.522
GCH1	W5PNS7_SHEEP	ENSOARP00000022652	ENSOARP00000012103	GTP cyclohydrolase 1.	Uncharacterized protein.	0.899
GCHFR	GCH1	ENSOARP00000021765	ENSOARP00000022652	GTP cyclohydrolase I feedback regulator.	GTP cyclohydrolase 1.	0.983
GCHFR	PTS	ENSOARP00000021765	ENSOARP00000017775	GTP cyclohydrolase I feedback regulator.	6-pyruvoyltetrahydropterin synthase.	0.614
GCHFR	SPR	ENSOARP00000021765	ENSOARP00000012467	GTP cyclohydrolase I feedback regulator.	Sepiapterin reductase.	0.784
GCHFR	W5PNS7_SHEEP	ENSOARP00000021765	ENSOARP00000012103	GTP cyclohydrolase I feedback regulator.	Uncharacterized protein.	0.614
HSP90AA1	CALM1	ENSOARP00000004171	ENSOARP00000003726	Heat shock protein alpha.	Calmodulin 1; Belongs to the calmodulin family.	0.500
HSP90AA1	CALM3	ENSOARP00000004171	ENSOARP00000011414	Heat shock protein alpha.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.881
HSP90AA1	LOC105614854	ENSOARP00000004171	ENSOARP00000022802	Heat shock protein alpha.	Uncharacterized protein; Belongs to the calmodulin family.	0.874