(133 nodes) Mixed, incl. Homeobox, and Cell fate specification network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX2-5	NK2 homeobox 5. (326 aa)
	MSGN1	Mesogenin 1. (193 aa)
	EOMES	Eomesodermin. (410 aa)
	TBXT	T-box transcription factor T. (365 aa)
	CBFA2T2	CBFA2/RUNX1 partner transcriptional co-repressor 2. (630 aa)
	TLX3	T cell leukemia homeobox 3. (291 aa)
	PHOX2B	Homeobox domain-containing protein. (178 aa)
	MYF6	Myogenic factor 6. (242 aa)
	FOXF1	Forkhead box F1. (433 aa)
	FOXP2	Fork-head domain-containing protein. (715 aa)
	TBX18	T-box transcription factor 18. (612 aa)
	DACH1	Dachshund family transcription factor 1. (590 aa)
	GATA4	GATA binding protein 4. (444 aa)
	HES7	Hes family bHLH transcription factor 7. (217 aa)
	OTX2	Orthodenticle homeobox 2. (289 aa)
	FEZF2	FEZ family zinc finger 2. (460 aa)
	MEOX1	Mesenchyme homeobox 1. (254 aa)
	DPPA2	SAP domain-containing protein. (301 aa)
	PRDM13	PR/SET domain 13. (719 aa)
	ONECUT1	One cut domain family member. (466 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	BARHL2	BarH like homeobox 2. (387 aa)
	SIX6	SIX homeobox 6. (246 aa)
	LHX4	LIM homeobox 4. (390 aa)
	LMX1A	LIM homeobox transcription factor 1 alpha. (382 aa)
	NR2E1	Uncharacterized protein. (475 aa)
	KLF4	Uncharacterized protein. (145 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1159 aa)
	PAX7	Paired box 7. (476 aa)
	BARX1	BARX homeobox 1. (311 aa)
	POU4F1	POU domain protein. (339 aa)
	G1SSE9_RABIT	Uncharacterized protein. (296 aa)
	NRL	Neural retina leucine zipper. (237 aa)
	FOXA2	Forkhead box A2. (471 aa)
	DBX1	Developing brain homeobox 1. (345 aa)
	LHX2	LIM homeobox 2. (414 aa)
	ZNF416	Uncharacterized protein. (537 aa)
	DLX6	Distal-less homeobox 6. (164 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
	LHX5	LIM homeobox 5. (402 aa)
	HELT	Helt bHLH transcription factor. (242 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	MYH8	Myosin heavy chain 8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
	RAX	Uncharacterized protein. (104 aa)
	MYOG	Myogenin. (225 aa)
	FBXO15	F-box domain-containing protein. (350 aa)
	SOX10	SRY-box transcription factor 10. (466 aa)
	CDX1	Caudal type homeobox 1. (266 aa)
	POU4F2	POU domain protein. (392 aa)
	SOX17	HMG box domain-containing protein. (165 aa)
	PITX2	Homeobox protein. (352 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	PAX2	Paired box 2. (448 aa)
	GBX2	Gastrulation brain homeobox 2. (344 aa)
	TLX1	T cell leukemia homeobox 1. (347 aa)
	LBX1	Ladybird homeobox 1. (260 aa)
	VAX1	Ventral anterior homeobox 1. (310 aa)
	TBX22	T-box transcription factor 22. (520 aa)
	GDF3	Growth differentiation factor 3. (365 aa)
	SIX1	SIX homeobox 1. (284 aa)
	PAX9	Paired box 9. (332 aa)
	TBX19	T-box transcription factor 19. (448 aa)
	TBX3	Uncharacterized protein. (242 aa)
	RERE	Arginine-glutamic acid dipeptide repeats. (1275 aa)
	EVX1	Even-skipped homeobox 1 (Predicted). (410 aa)
	CUX1	Cut like homeobox 1. (1267 aa)
	HAND2	BHLH domain-containing protein. (426 aa)
	SALL3	Spalt like transcription factor 3. (1278 aa)
	POU5F1	POU domain protein. (360 aa)
	PAX3	Paired box 3. (484 aa)
	POU1F1	POU domain protein. (281 aa)
	SOX1	SRY-box transcription factor 1. (377 aa)
	HCN4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. (913 aa)
	ZIC3	Zic family member 3. (467 aa)
	SOX11	Transcription factor SOX. (446 aa)
	ZIC5	Uncharacterized protein. (159 aa)
	OTX1	Orthodenticle homeobox 1. (324 aa)
	SOX14	SRY-box transcription factor 14. (240 aa)
	EMX1	Empty spiracles homeobox 1. (241 aa)
	SOX3	SRY-box transcription factor 3. (445 aa)
	ATN1	Atrophin 1. (1180 aa)
	MEOX2	Mesenchyme homeobox 2. (303 aa)
	G1TQE3_RABIT	Fork-head domain-containing protein. (520 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	PAX6	Uncharacterized protein. (436 aa)
	PROP1	PROP paired-like homeobox 1. (227 aa)
	EYA4	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	MIXL1	Mix paired-like homeobox. (234 aa)
	LOC100101568	Left-right determination factor. (368 aa)
	VSX2	Visual system homeobox 2. (363 aa)
	SIX2	SIX homeobox 2. (295 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (272 aa)
	ZIC2	Uncharacterized protein. (272 aa)
	NANOG	Homeobox domain-containing protein. (306 aa)
	TBX2	T-box transcription factor 2. (662 aa)
	CUX2	Homeobox protein cut-like. (1395 aa)
	EMX2	Empty spiracles homeobox 2. (253 aa)
	LHX1	LIM homeobox 1. (313 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (364 aa)
	G1U6Y9_RABIT	Uncharacterized protein. (101 aa)
	PRDM14	PR/SET domain 14. (568 aa)
	SALL4	Spalt like transcription factor 4. (994 aa)
	SHOX2	Short stature homeobox 2. (211 aa)
	TBX6	T-box transcription factor 6. (488 aa)
	FOXN4	Forkhead box N4. (518 aa)
	TAL2	TAL bHLH transcription factor 2. (142 aa)
	TBX20	T-box transcription factor 20. (460 aa)
	POU3F3	POU domain protein. (344 aa)
	TFCP2L1	Transcription factor CP2 like 1. (495 aa)
	SOX6	SRY-box transcription factor 6. (855 aa)
	CRX	Uncharacterized protein. (42 aa)
	CA12	Carbonic anhydrase 12; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. (372 aa)
	SOX13	SRY-box transcription factor 13. (663 aa)
	THRB	Thyroid hormone receptor beta. (476 aa)
	PAX1	Paired box 1. (431 aa)
	DLX5	Distal-less homeobox 5. (313 aa)
	SOX17-2	Sox C-terminal domain-containing protein. (123 aa)
	ATOH7	Atonal bHLH transcription factor 7. (152 aa)
	ANHX	Anomalous homeobox. (474 aa)
	SOX5	SRY-box transcription factor 5. (779 aa)
	ESRRB	Estrogen related receptor beta. (454 aa)
	TDGF1	EGF-like domain-containing protein. (259 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
	NKX1-2	NK1 homeobox 2. (302 aa)
	ISL2	ISL LIM homeobox 2. (440 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	DPPA5	MOEP19 domain-containing protein. (175 aa)
	EYA3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (596 aa)
	POU6F2	POU domain protein. (697 aa)
	MDFI	MyoD family inhibitor (Predicted). (246 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANHX	DLX1	ENSOCUP00000038073	ENSOCUP00000003211	Anomalous homeobox.	Distal-less homeobox 1.	0.440
ANHX	EYA1	ENSOCUP00000038073	ENSOCUP00000007819	Anomalous homeobox.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.581
ANHX	EYA2	ENSOCUP00000038073	ENSOCUP00000043838	Anomalous homeobox.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.581
ANHX	EYA3	ENSOCUP00000038073	ENSOCUP00000048698	Anomalous homeobox.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.581
ANHX	EYA4	ENSOCUP00000038073	ENSOCUP00000019852	Anomalous homeobox.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.581
ANHX	VSX2	ENSOCUP00000038073	ENSOCUP00000021200	Anomalous homeobox.	Visual system homeobox 2.	0.401
ATN1	NR2E1	ENSOCUP00000018522	ENSOCUP00000005071	Atrophin 1.	Uncharacterized protein.	0.867
ATN1	NRL	ENSOCUP00000018522	ENSOCUP00000006184	Atrophin 1.	Neural retina leucine zipper.	0.410
ATN1	RERE	ENSOCUP00000018522	ENSOCUP00000012783	Atrophin 1.	Arginine-glutamic acid dipeptide repeats.	0.476
ATOH7	BARHL2	ENSOCUP00000037999	ENSOCUP00000003642	Atonal bHLH transcription factor 7.	BarH like homeobox 2.	0.533
ATOH7	CRX	ENSOCUP00000037999	ENSOCUP00000031844	Atonal bHLH transcription factor 7.	Uncharacterized protein.	0.730
ATOH7	FOXN4	ENSOCUP00000037999	ENSOCUP00000029433	Atonal bHLH transcription factor 7.	Forkhead box N4.	0.749
ATOH7	ISL1	ENSOCUP00000037999	ENSOCUP00000020036	Atonal bHLH transcription factor 7.	ISL LIM homeobox 1.	0.720
ATOH7	ISL2	ENSOCUP00000037999	ENSOCUP00000046326	Atonal bHLH transcription factor 7.	ISL LIM homeobox 2.	0.444
ATOH7	LHX2	ENSOCUP00000037999	ENSOCUP00000006701	Atonal bHLH transcription factor 7.	LIM homeobox 2.	0.477
ATOH7	NR2E1	ENSOCUP00000037999	ENSOCUP00000005071	Atonal bHLH transcription factor 7.	Uncharacterized protein.	0.415
ATOH7	ONECUT1	ENSOCUP00000037999	ENSOCUP00000002873	Atonal bHLH transcription factor 7.	One cut domain family member.	0.705
ATOH7	OTX2	ENSOCUP00000037999	ENSOCUP00000002270	Atonal bHLH transcription factor 7.	Orthodenticle homeobox 2.	0.596
ATOH7	PAX6	ENSOCUP00000037999	ENSOCUP00000019685	Atonal bHLH transcription factor 7.	Uncharacterized protein.	0.692
ATOH7	POU4F1	ENSOCUP00000037999	ENSOCUP00000005806	Atonal bHLH transcription factor 7.	POU domain protein.	0.620