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MMP27 MMP27 MMP8 MMP8 CTSG CTSG PLG PLG MMP13 MMP13 SPOCK3 SPOCK3 FRZB FRZB MMP24 MMP24 TIMP1 TIMP1 CTSK CTSK G1T0M4_RABIT G1T0M4_RABIT MMP16 MMP16 KLKB1 KLKB1 ANKRD16 ANKRD16 MMP3 MMP3 MMP7 MMP7 SFRP4 SFRP4 MMP10 MMP10 CMA1 CMA1 MMP11 MMP11 MMP15 MMP15 MMP9 MMP9 LOC100341936 LOC100341936 LOC103348521 LOC103348521 FURIN FURIN SPOCK1 SPOCK1 ENSOCUP00000030281 ENSOCUP00000030281 MMP2 MMP2 MMP1 MMP1 LOC100339353 LOC100339353 CTRL CTRL PRSS2 PRSS2 ENSOCUP00000047896 ENSOCUP00000047896
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP27Matrix metallopeptidase 27. (527 aa)
MMP8Matrix metallopeptidase 8. (355 aa)
CTSGCathepsin G. (250 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (774 aa)
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
SPOCK3SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3. (344 aa)
FRZBFrizzled related protein. (318 aa)
MMP24Matrix metallopeptidase 24. (617 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (256 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa)
G1T0M4_RABITPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (629 aa)
ANKRD16ANK_REP_REGION domain-containing protein. (362 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
MMP7Matrix metallopeptidase 7. (273 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
MMP10Matrix metallopeptidase 10. (477 aa)
CMA1Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. (220 aa)
MMP11Matrix metallopeptidase 11. (492 aa)
MMP15U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family. (822 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
LOC100341936Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
LOC103348521NTR domain-containing protein. (225 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (666 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (466 aa)
ENSOCUP00000030281Uncharacterized protein. (155 aa)
MMP272 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (710 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
LOC100339353Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (249 aa)
PRSS2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
ENSOCUP00000047896Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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