(23 nodes) Zinc-dependent metalloprotease network (Oryctolagus cuniculus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	MMP1	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
	ENSOCUP00000029581	Metalloendopeptidase. (828 aa)
	BMP1	Metalloendopeptidase. (984 aa)
	ENSOCUP00000028629	Metalloendopeptidase. (714 aa)
	MMP15	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family. (822 aa)
	MMP11	Matrix metallopeptidase 11. (492 aa)
	MMP10	Matrix metallopeptidase 10. (477 aa)
	G1TEH0_RABIT	Metalloendopeptidase. (628 aa)
	MMP7	Matrix metallopeptidase 7. (273 aa)
	MMP3	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
	MEP1B	Meprin A subunit. (716 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	MMP24	Matrix metallopeptidase 24. (617 aa)
	MMP12	Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (464 aa)
	G1SN82_RABIT	ZnMc domain-containing protein. (300 aa)
	MMP28	Matrix metallopeptidase 28. (521 aa)
	MMP26	Matrix metallopeptidase 26. (265 aa)
	MMP20	Matrix metallopeptidase 20. (483 aa)
	MMP13	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
	MMP21	Matrix metallopeptidase 21; Belongs to the peptidase M10A family. (567 aa)
	MEP1A	Meprin A subunit. (749 aa)
	MMP8	Matrix metallopeptidase 8. (355 aa)
	MMP27	Matrix metallopeptidase 27. (527 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1SN82_RABIT	MMP10	ENSOCUP00000004425	ENSOCUP00000015427	ZnMc domain-containing protein.	Matrix metallopeptidase 10.	0.402
G1SN82_RABIT	MMP20	ENSOCUP00000004425	ENSOCUP00000002545	ZnMc domain-containing protein.	Matrix metallopeptidase 20.	0.425
G1SN82_RABIT	MMP3	ENSOCUP00000004425	ENSOCUP00000013084	ZnMc domain-containing protein.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family.	0.411
G1SN82_RABIT	MMP8	ENSOCUP00000004425	ENSOCUP00000000947	ZnMc domain-containing protein.	Matrix metallopeptidase 8.	0.601
MEP1A	MEP1B	ENSOCUP00000001280	ENSOCUP00000011831	Meprin A subunit.	Meprin A subunit.	0.922
MEP1B	MEP1A	ENSOCUP00000011831	ENSOCUP00000001280	Meprin A subunit.	Meprin A subunit.	0.922
MMP1	MMP10	ENSOCUP00000036318	ENSOCUP00000015427	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 10.	0.527
MMP1	MMP11	ENSOCUP00000036318	ENSOCUP00000021114	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 11.	0.556
MMP1	MMP12	ENSOCUP00000036318	ENSOCUP00000007180	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family.	0.505
MMP1	MMP13	ENSOCUP00000036318	ENSOCUP00000002145	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.482
MMP1	MMP15	ENSOCUP00000036318	ENSOCUP00000021442	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family.	0.487
MMP1	MMP16	ENSOCUP00000036318	ENSOCUP00000009663	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 16.	0.440
MMP1	MMP20	ENSOCUP00000036318	ENSOCUP00000002545	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 20.	0.440
MMP1	MMP21	ENSOCUP00000036318	ENSOCUP00000001437	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 21; Belongs to the peptidase M10A family.	0.410
MMP1	MMP24	ENSOCUP00000036318	ENSOCUP00000009118	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 24.	0.443
MMP1	MMP26	ENSOCUP00000036318	ENSOCUP00000003039	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 26.	0.494
MMP1	MMP3	ENSOCUP00000036318	ENSOCUP00000013084	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family.	0.951
MMP1	MMP7	ENSOCUP00000036318	ENSOCUP00000013167	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	Matrix metallopeptidase 7.	0.619
MMP10	G1SN82_RABIT	ENSOCUP00000015427	ENSOCUP00000004425	Matrix metallopeptidase 10.	ZnMc domain-containing protein.	0.402
MMP10	MMP1	ENSOCUP00000015427	ENSOCUP00000036318	Matrix metallopeptidase 10.	Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family.	0.527