(46 nodes) Legionellosis network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	CASP8	DED domain-containing protein. (109 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	BNIP3	BCL2 interacting protein 3. (218 aa)
	TLR2	TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
	PYCARD	PYD and CARD domain containing. (196 aa)
	SAR1A	Secretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	IL18	Uncharacterized protein. (408 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	EEF1A1	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. (462 aa)
	CLK1	CDC like kinase 1; Belongs to the protein kinase superfamily. (484 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (303 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1183 aa)
	HSPD1	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (573 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	BCL2L13	BCL2 like 13. (465 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
	RAB1A	RAB1A, member RAS oncogene family. (205 aa)
	LOC100354468	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	LOC100341515	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LOC100353673	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
	G1TUQ7_RABIT	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LOC108178730	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
	LOC100357840	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (968 aa)
	ARF1-2	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	LOC100343501	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (196 aa)
	ITGAM	Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa)
	GRO-B	Permeability factor 2; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
	HSPA8	Uncharacterized protein. (917 aa)
	MYD88	Uncharacterized protein. (476 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
	ITGB2	Integrin beta. (1009 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like. (414 aa)
	HBS1L	HBS1_N domain-containing protein. (635 aa)
	CLK4	CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
	SAR1B	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (295 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (466 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (219 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BNIP3	ENSOCUP00000010200	ENSOCUP00000002192	Apoptotic peptidase activating factor 1.	BCL2 interacting protein 3.	0.408
APAF1	CASP1	ENSOCUP00000010200	ENSOCUP00000000956	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.881
APAF1	CASP3	ENSOCUP00000010200	ENSOCUP00000036614	Apoptotic peptidase activating factor 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.998
APAF1	CASP7	ENSOCUP00000010200	ENSOCUP00000009498	Apoptotic peptidase activating factor 1.	Caspase 7; Belongs to the peptidase C14A family.	0.940
APAF1	CASP8	ENSOCUP00000010200	ENSOCUP00000049942	Apoptotic peptidase activating factor 1.	DED domain-containing protein.	0.977
APAF1	CASP9	ENSOCUP00000010200	ENSOCUP00000047129	Apoptotic peptidase activating factor 1.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSOCUP00000010200	ENSOCUP00000019281	Apoptotic peptidase activating factor 1.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	G1TUQ7_RABIT	ENSOCUP00000010200	ENSOCUP00000020783	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	HBS1L	ENSOCUP00000010200	ENSOCUP00000040760	Apoptotic peptidase activating factor 1.	HBS1_N domain-containing protein.	0.606
APAF1	LOC100341515	ENSOCUP00000010200	ENSOCUP00000017626	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC100353673	ENSOCUP00000010200	ENSOCUP00000020297	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC100354468	ENSOCUP00000010200	ENSOCUP00000015773	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC100357840	ENSOCUP00000010200	ENSOCUP00000021980	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC108178730	ENSOCUP00000010200	ENSOCUP00000021195	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	TNF	ENSOCUP00000010200	ENSOCUP00000005787	Apoptotic peptidase activating factor 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.485
ARF1-2	LOC100343501	ENSOCUP00000023735	ENSOCUP00000025339	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.900
ARF1-2	RAB1A	ENSOCUP00000023735	ENSOCUP00000014605	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	RAB1A, member RAS oncogene family.	0.598
ARF1-2	SEC22B	ENSOCUP00000023735	ENSOCUP00000049216	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family.	0.740
BCL2L13	BNIP3	ENSOCUP00000013955	ENSOCUP00000002192	BCL2 like 13.	BCL2 interacting protein 3.	0.745
BNIP3	APAF1	ENSOCUP00000002192	ENSOCUP00000010200	BCL2 interacting protein 3.	Apoptotic peptidase activating factor 1.	0.408