STRINGSTRING
MAPK12 MAPK12 ACTR3B ACTR3B LCP2 LCP2 ARHGEF28 ARHGEF28 WIPF3 WIPF3 CRKL CRKL CASP1 CASP1 DOCK1 DOCK1 ARF6 ARF6 MAP3K7 MAP3K7 TLR4 TLR4 RPS6KA2 RPS6KA2 ELMO1 ELMO1 ITGB1 ITGB1 LCK LCK ACTR3 ACTR3 PYCARD PYCARD PIK3CB PIK3CB PIK3R1 PIK3R1 IL18 IL18 NLRP3 NLRP3 ZAP70 ZAP70 WIPF2 WIPF2 NFATC1 NFATC1 TNF TNF IKBKB IKBKB MAP2K6 MAP2K6 WASL WASL CD8B CD8B RAC1 RAC1 NFATC3 NFATC3 IL2 IL2 FN1 FN1 MAPK10 MAPK10 SKAP2 SKAP2 TAB2 TAB2 RHOA RHOA ITGA5 ITGA5 MAPK1 MAPK1 MAPK3 MAPK3 LOC100345250 LOC100345250 PIP5K1A PIP5K1A WAS WAS NFKBIA NFKBIA GNAQ GNAQ RHOG RHOG CCL2 CCL2 LOC100356250 LOC100356250 TAB1 TAB1 LOC100346856 LOC100346856 IL6 IL6 MAP2K7 MAP2K7 IGHM-2 IGHM-2 PTK2B PTK2B CXCL8 CXCL8 WASF2 WASF2 MAPK8 MAPK8 BAIAP2 BAIAP2 IL10 IL10 LOC100348967 LOC100348967 IFNB1 IFNB1 PIK3CD PIK3CD PLCG1 PLCG1 FOS FOS IL1B IL1B ITGA4 ITGA4 G1TYN5_RABIT G1TYN5_RABIT LIMK1 LIMK1 NFKB1 NFKB1 IGHM-3 IGHM-3 CDC42-2 CDC42-2 PIK3CA PIK3CA TRAF6 TRAF6 MAP2K1 MAP2K1 IRAK1 IRAK1 CD4 CD4 MAPK9 MAPK9 WIPF1 WIPF1 CHUK CHUK FCGR2A FCGR2A IRAK4 IRAK4 PIP5K1B PIP5K1B MYD88 MYD88 ROCK1 ROCK1 GSK3B GSK3B ENSOCUP00000035377 ENSOCUP00000035377 MAP2K4 MAP2K4 TBK1 TBK1 VAV3 VAV3 ENSOCUP00000037393 ENSOCUP00000037393 BCAR1 BCAR1 ELMO2 ELMO2 ACTR2 ACTR2 PTK2-2 PTK2-2 RPS6KA3 RPS6KA3 JUN JUN RPS6KA1 RPS6KA1 AKT3 AKT3 ENSOCUP00000041377 ENSOCUP00000041377 ARHGEF12 ARHGEF12 GIT2 GIT2 NFATC2 NFATC2 IKBKG IKBKG CD8A CD8A ACTB ACTB MAPK13 MAPK13 LOC100341883 LOC100341883 PKN2 PKN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (416 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (418 aa)
LCP2Lymphocyte cytosolic protein 2. (534 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1624 aa)
WIPF3WAS/WASL interacting protein family member 3. (447 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (687 aa)
ELMO1Engulfment and cell motility 1. (742 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
LCKTyrosine-protein kinase. (637 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (418 aa)
PYCARDPYD and CARD domain containing. (196 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IL18Uncharacterized protein. (408 aa)
NLRP3NLR family pyrin domain containing 3. (1046 aa)
ZAP70Tyrosine-protein kinase. (623 aa)
WIPF2WH2 domain-containing protein. (439 aa)
NFATC1RHD domain-containing protein. (672 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
WASLWASP like actin nucleation promoting factor. (512 aa)
CD8BIg-like domain-containing protein. (206 aa)
RAC1Rac family small GTPase 1. (199 aa)
NFATC3Nuclear factor of activated T cells 3. (1070 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2427 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SKAP2Src kinase associated phosphoprotein 2. (358 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
RHOARas homolog family member A. (193 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
LOC100345250Uncharacterized protein. (461 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (563 aa)
WASWASP actin nucleation promoting factor. (527 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
GNAQG protein subunit alpha q. (325 aa)
RHOGRas homolog family member G. (191 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
LOC100356250Uncharacterized protein. (292 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LOC100346856Uncharacterized protein. (316 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
WASF2WASP family member 2. (496 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BAIAP2IMD domain-containing protein. (322 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
LOC100348967Uncharacterized protein. (316 aa)
IFNB1Interferon beta 1. (180 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
LIMK1LIM domain kinase 1. (645 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
CDC42-2Uncharacterized protein. (222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
WIPF1WH2 domain-containing protein. (509 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
FCGR2AUncharacterized protein. (323 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (464 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (612 aa)
MYD88Uncharacterized protein. (476 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
TBK1TANK binding kinase 1. (836 aa)
VAV3Vav guanine nucleotide exchange factor 3. (964 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (869 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (425 aa)
PTK2-2FERM_N_2 domain-containing protein. (121 aa)
RPS6KA3Ribosomal protein S6 kinase. (751 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
RPS6KA1Ribosomal protein S6 kinase. (813 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
GIT2GIT ArfGAP 2. (765 aa)
NFATC2Nuclear factor of activated T cells 2. (900 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
CD8AIg-like domain-containing protein. (394 aa)
ACTBUncharacterized protein. (357 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
LOC100341883Protein kinase domain-containing protein. (262 aa)
PKN2Protein kinase N2. (996 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.