(26 nodes) African trypanosomiasis network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	ICAM1	Intercellular adhesion molecule 1. (534 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (402 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (421 aa)
	IL18	Uncharacterized protein. (408 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
	LAMA4	Laminin subunit alpha 4. (1732 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
	GNAQ	G protein subunit alpha q. (325 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	IGHM-2	Ig-like domain-containing protein. (167 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
	G1TYN5_RABIT	Ig-like domain-containing protein. (119 aa)
	IGHM-3	Ig-like domain-containing protein. (167 aa)
	KNG1	Kininogen 1. (633 aa)
	FAS	Uncharacterized protein. (484 aa)
	MYD88	Uncharacterized protein. (476 aa)
	ENSOCUP00000035377	Ig-like domain-containing protein. (160 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
	ENSOCUP00000037393	Uncharacterized protein. (92 aa)
	ENSOCUP00000041377	Ig-like domain-containing protein. (148 aa)
	PRKCB	Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
	TLR9	TIR domain-containing protein. (1027 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F2RL1	GNAQ	ENSOCUP00000002228	ENSOCUP00000014234	F2R like trypsin receptor 1.	G protein subunit alpha q.	0.938
F2RL1	KNG1	ENSOCUP00000002228	ENSOCUP00000033073	F2R like trypsin receptor 1.	Kininogen 1.	0.456
FAS	IL1B	ENSOCUP00000033980	ENSOCUP00000021869	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.409
GNAQ	F2RL1	ENSOCUP00000014234	ENSOCUP00000002228	G protein subunit alpha q.	F2R like trypsin receptor 1.	0.938
GNAQ	PLCB1	ENSOCUP00000014234	ENSOCUP00000036536	G protein subunit alpha q.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.974
GNAQ	PLCB2	ENSOCUP00000014234	ENSOCUP00000005658	G protein subunit alpha q.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.967
ICAM1	IDO1	ENSOCUP00000027126	ENSOCUP00000002899	Intercellular adhesion molecule 1.	Indoleamine 2,3-dioxygenase 1.	0.436
ICAM1	IL10	ENSOCUP00000027126	ENSOCUP00000019534	Intercellular adhesion molecule 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.803
ICAM1	IL18	ENSOCUP00000027126	ENSOCUP00000004555	Intercellular adhesion molecule 1.	Uncharacterized protein.	0.696
ICAM1	IL1B	ENSOCUP00000027126	ENSOCUP00000021869	Intercellular adhesion molecule 1.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.889
ICAM1	IL6	ENSOCUP00000027126	ENSOCUP00000017266	Intercellular adhesion molecule 1.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.910
ICAM1	MYD88	ENSOCUP00000027126	ENSOCUP00000034296	Intercellular adhesion molecule 1.	Uncharacterized protein.	0.665
ICAM1	TLR9	ENSOCUP00000027126	ENSOCUP00000047700	Intercellular adhesion molecule 1.	TIR domain-containing protein.	0.531
ICAM1	TNF	ENSOCUP00000027126	ENSOCUP00000005787	Intercellular adhesion molecule 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.433
IDO1	ICAM1	ENSOCUP00000002899	ENSOCUP00000027126	Indoleamine 2,3-dioxygenase 1.	Intercellular adhesion molecule 1.	0.436
IDO1	IDO2	ENSOCUP00000002899	ENSOCUP00000002903	Indoleamine 2,3-dioxygenase 1.	Indoleamine 2,3-dioxygenase 2.	0.917
IDO1	IL10	ENSOCUP00000002899	ENSOCUP00000019534	Indoleamine 2,3-dioxygenase 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.834
IDO1	IL1B	ENSOCUP00000002899	ENSOCUP00000021869	Indoleamine 2,3-dioxygenase 1.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.707
IDO1	IL6	ENSOCUP00000002899	ENSOCUP00000017266	Indoleamine 2,3-dioxygenase 1.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.745
IDO1	TLR9	ENSOCUP00000002899	ENSOCUP00000047700	Indoleamine 2,3-dioxygenase 1.	TIR domain-containing protein.	0.430