STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0105SCJ11.34c, xlnC, endo-1,4-beta-xylanase (putative secreted protein), len: 241 aa; highly similar to many endo-1,4-beta-xylanases e.g. SW:XYNC_STRLI from Streptomyces lividans (240 aa) fasta scores; opt: 1605, z-score: 1785.1, E(): 0, (97.9% identity in 241 aa overlap) and SW:XYNA_BACSU from Bacillus subtilis (213 aa) fasta scores; opt: 813, z-score: 910.7, E(): 0, (58.8% identity in 221 aa overlap). Contains Pfam match to entry PF00457 Glyco_hydro_11, Glycosyl hydrolases family 11 and Prosite matches to PS00777 Glycosyl hydrolases family 11 active site signature 2 and PS00776 Glycosyl [...] (241 aa)    
Predicted Functional Partners:
SCO5931
SC10A5.36c, xlnA, xylanase A precursor, partial CDS, len >383 aa; overlaps and extends ORF from neighbouring cosmid SC7H1.01c; almost identical to XYNA_STRLI P26514 endo- 1,4-beta-xylanase a precursor (477 aa) (99.2% identity in 383 aa overlap). Conatains PS00591 Glycosyl hydrolases famil y 10 active site and Pfam match to entry glycosyl_hydro3 PF 00331, Glycosyl hydrolases family 10, score 183.41. Also si milar in part to S. coelicolor SC7H1.02, abfB, arabinofuran osidase (E(): 1.4e-35, 58.4% identity in 149 aa overlap); SC7H1.01c, xlnA, xylanase A precursor, partial CDS, len >147 aa; [...]
   
 0.966
SCO2291
SCC75A.37, axeA, secreted acetylxylan esterase, len: 335 aa. Almost identical in sequence with Streptomyces lividans TR:Q54413 (EMBL:M64552) acetylxylan esterase precursor (EC 3.1.1.72) (335 aa), fasta scores opt: 2197 z-score: 2058.4 E(): 0 98.5% identity in 335 aa overlap. Also highly similar to the C-terminus of Cellulomonas fimi SW:XYND_CELFI (EMBL:X76729) endo-1,4-beta-xylanase D precursor (EC 3.2.1.8) (644 aa), fasta scores opt: 1108 z-score: 1040.5 E(): 0 50.0% identity in 346 aa overlap. Also similar to the adjoining CDS on this cosmid, xlnB, (335 aa), fasta scores opt: 652 z-s [...]
     0.907
SCO0674
SCF91.34c, xysA, secreted endo-1,4-beta-xylanase (EC 3.2.1.8), len: 450 aa. Highly similar to many including: Streptomyces lividans SW:XYNA_STRLI(EMBL:M64551) endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) (477 aa),fasta scores opt: 1313 z-score: 1280.4 E(): 0 49.0% identity in 459 aa overlap and Streptomyces halstedii TR:Q59922(EMBL:U41627) endo-1,4-beta-xylanase (EC 3.2.1.8) (461 aa), fasta scores opt: 2301 z-score: 2238.0 E():0 76.9% identity in 438 aa overlap. Contains Pfam matches to entries PF00553 CBD_2, Cellulose binding domain and Pfam match to entry PF00331 Glyco_hydro_10, G [...]
   
 0.792
SCO2024
Putative chitosanase (putative secreted protein); Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.
      
 0.777
SCO0677
Secreted chitosanase; Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.
      
 0.776
SCO1110
2SCG38.03, probable secreted lyase, len: 266 aa; similar to TR:Q04701 (EMBL:M94691) Fusarium solani pectate lyase A precursor (EC 4.2.2.2) PelA, 242 aa; fasta scores: opt: 605 z-score: 664.1 E(): 1.5e-29; 43.6% identity in 236 aa overlap. Contains possible N-terminal region signal peptide sequence.
  
   
 0.769
SCO5932
Arabinofuranosidase; Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well (By similarity); Belongs to the glycosyl hydr olase 62 family.
 
     0.768
SCO6545
SC5C7.30c, probable secreted cellulase, len: 890 aa; similar to TR:D1029971 (EMBL:AB015511) Aspergillus aculeatus avicelase III (856 aa), fasta scores; opt: 2099 z-score: 1414.5 E(): 0, 44.5% identity in 845 aa overlap, and to many others e.g. GUNA_MICBI endoglucanase A precursor (EC 3.2.1.4) (456 aa), fasta scores; opt: 416 z-score: 340.7 E(): 9.9e-12, 28.5% identity in 449 aa overlap (strongest in the cellulose-binding domain). Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 171.70, E-value 8.5e-49 at C-terminus.
  
     0.741
SCO5786
SC4H2.07c, possible secreted hydrolase, len: 400 aa; similar in N-terminus to many e.g GUNA_STRLI P27035 endoglucanase CelA precursor (459 aa), fasta scores; opt: 376 z-score: 257.5 E(): 4e-07, 37.7% identity in 175 aa overlap. Contains a very Thr- Pro-rich region at aa 143-170, a possible N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. C-terminal region has no apparent similarities. Also contains a TTA leucine codon; a potential target for action of bldA.
 
     0.732
SCO1187
SCG11A.18, celB, secreted cellulase B precursor, len: 381 aa; identical to TR:Q54331 (EMBL:U04629) Streptomyces lividans cellulase precursor, celB, 381 aa and similar to SW:GUX_CELFI (EMBL:M15824) Cellulomonas fimi exoglucanase/xylanase precursor [includes: exoglucanase (EC 3.2.1.91) (exocellobiohydrolase) (1,4-beta-cellobiohydrolase) (beta-1,4- glycanase Cex); endo-1,4-beta-xylanase B (EC 3.2.1.8) (xylanase B) Cex or XynB, 484 aa; fasta scores: opt: 422 z-score: 450.5 E(): 1e-17; 48.8% identity in 123 aa overlap. Contains two matches to Pfam entries PF01670 Glyco_hydro_12, Glycosyl hy [...]
 
     0.729
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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