STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0164SCJ1.13, putative cation-transporting ATPase, len: 776 aa, similar to many including: Mycobacterium tuberculosis SW:CTPG_MYCTU (EMBL:Z74025) probable cation-transporting ATPase G (771 aa), fasta scores opt: 1050 z-score: 1095.0 E(): 0 37.6% identity in 588 aa overlap, Mycobacterium tuberculosis TR:O66027 (EMBL:U82820)(EMBL metal-transporting ATPase MTA72 (680 aa), fasta scores opt: 1036 z-score: 1081.2 E(): 0 33.8% identity in 577 aa overlap and Helicobacter felis SW:COPA_HELFE (EMBL: AJ001932) copper-transporting ATPase (EC 3.6.1.36) (732 aa), fasta scores opt: 904 z-score: 943.3 E(): [...] (776 aa)    
Predicted Functional Partners:
SCO2730
SCC57A.01, possible regulator, partial CDS, len: > 47 aa. Similar to the C-terminus of Streptomyces coelicolor TR:CAB61163 (EMBL:AL132973) putative TetR-family transcriptional regulator (194 aa), fasta scores opt: 85 z-score: 133.1 E():5 58.1% identity in 31 aa overlap; SCC46.15, possible regulator (fragment), len: >89 aa; N-terminal region of TR:CAB66269 (EMBL:AL136519) Streptomyces coelicolor putative regulator (fragment) SCC57A.01.
  
 
 0.944
SCO7094
Flavohemoprotein; SC3A4.20c, hmpA2, flavohemoprotein (hemoglobin-like protein), len: 403 aa. Highly similar to many including: Escherichia coli SW:HMPA_ECOLI (EMBL:X58872) flavohemoprotein, HmpA (396 aa), fasta scores: opt: 833 z-score: 947.5 E():0 37.9% identity in 406 aa overlap and Streptomyces coelicolor TR:CAB76347 (EMBL:AL158061) flavohemoprotein, HmpA1 or SC6D11.24 (398 aa), fasta scores: opt: 1706 z-score: 1936.1 E(): 0 65.3% identity in 404 aa overlap. contains Pfam matches to entries PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain and PF00042 globin, Globin; Belon [...]
  
  
 0.920
SCO7428
Flavohemoprotein; SC6D11.24, hmpA1, possible flavohemoprotein, len: 398 aa. Highly similar to many protein of the flavohemoprotein subfamily, including: Escherichia coli SW:HMPA_ECOLI(EMBL:X58872) flavohemoprotein (hemoglobin-like protein) (396 aa), fasta scores: opt: 826 z-score: 935.2 E():0 39.4% identity in 404 aa overlap and Erwinia chrysanthemi SW:HMPA_ERWCH (EMBL:X75893) flavohemoprotein (395 aa), fasta scores: opt: 761 z-score: 862.0 E():0 35.9% identity in 404 aa overlap. Contains Pfam matches to entries Pfam match to entry PF00042 globin, Globin and Pfam match to entry PF00175 [...]
  
  
 0.920
SCO1045
SCG20A.25, possible metal associated protein, len: 77 aa; similar to SW:COPP_HELFE (EMBL:AJ001932) Helicobacter felis cop associated protein (copper ion binding protein) CopP, 66 aa; fasta scores: opt: 153 z-score: 210.7 E(): 0.00029; 40.7% identity in 59 aa overlap and to TR:Q9RDJ5 (EMBL:AL136519) Streptomyces coelicolor putative regulator (fragment) SCC57A.01, >47 aa; fasta scores: opt: 146 z-score: 186.0 E(): 9.3e-05; 53.2% identity in 47 aa overlap. Contains Pfam match to entry PF00403 HMA, Heavy-metal-associated domain.
  
 
 0.901
SCO0103
SCJ11.32, probable flavohemoprotein, len: 435aa; C-terminal region similar to many with reductase and dioxygenase activities, typical of flavohemoproteins e.g. TR:Q9ZI75 (EMBL:AF039533) naphthalene dioxygenase reductase from Pseudomonas stutzeri (328 aa) fasta scores; opt: 369, z-score: 419.0, E(): 5.6e-16, (28.6% identity in 241 aa overlap). Also typical of flavohemoprotein, C-terminal region contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain and N-terminal region contains Pfam match to entry PF00042 globin, Globin; Belongs to the globin family.
  
  
 0.866
SCO1044
SCG20A.24c, possible secreted protein, len: 313 aa. Contains possible N-terminal region signal peptide sequence.
 
  
 0.798
SCO3280
SCE39.30, putative membrane protein, len: 203 aa; similar to another from Streptomyces coelicolor cosmid 5C7 TR:O86731 (EMBL:AL031515) hypothetical protein (314 aa) fasta scores; opt: 163, z-score: 187.7, E(): 0.0038, (31.8% identity in 154 aa overlap). Contains histidine-rich N-terminal region. Contains possible hydrophobic membrane spanning regions.
     
 0.779
SCO3281
Conserved hypothetical protein; SCE39.31c, unknown, len: 136aa; similar to TR:O68643 (EMBL:AF052749) hypothetical protein from Pseudomonas putida (109 aa) fasta scores; opt: 359, z-score: 415.3, E(): 8.1e-16, (41.3% identity in 109 aa overlap).
     
 0.775
SCO0163
Conserved hypothetical protein SCJ1.12; SCJ1.12 unkown, len: 508 aa, similar to Mycobacterium tuberculosis SW:YW13_MYCTU (EMBL; Z74025) hypothetical 54.4 KD protein CY39.13 (498 aa),fasta scores opt: 1192 z-score: 1332.4 E(): 0 43.8% identity in 470 aa overlap and Aquifex aeolicus TR:O66641 (EMBL: AE000682) hypothetical 38.3 KD protein (322 aa), fasta scores opt: 550 z-score: 618.7 E(): 4.2e-27 35.5% identity in 279 aa overlap. Contains a PS00017 ATP/GTP-binding site motif A (P-loop).
 
    0.693
SCO2222
SC10B7.17, probable iron-sulfur oxidoreductase (putative secreted protein), len: 364 aa; similar to TR:O88034 (EMBL:AL031107) Streptomyces coelicolor iron-sulfur oxidoreductase beta subunit SC5A7.28c, 313 aa; fasta scores: opt: 1032 z-score: 1177.8 E(): 0; 55.2% identity in 310 aa overlap and to SW:POBB_PSEPS (EMBL:X78823) Pseudomonas pseudoalcaligenes phenoxybenzoate dioxygenase beta subunit (EC 1.-.-.-.) PobB, 319 aa; fasta scores: opt: 680 z-score: 777.9 E(): 0; 40.8% identity in 314 aa overlap. Contains two matches to Pfam entries Pfam match to entry PF00175 oxidored_fad, Oxidoredu [...]
  
  
 0.690
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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