STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0332SCF12.11, possible transcriptional regulator, len: 206 aa; similar to many e.g. TR:AAD31815 (EMBL:AF129856) transcriptional repressor from Pseudomonas fluorescens (208 aa) fasta scores; opt: 275, z-score: 343.1, E(): 9.3e-12, 30.0% identity in 200 aa overlap. Contains probable helix-turn-helix motif (+5.38 SD) 45-66aa. (206 aa)    
Predicted Functional Partners:
SCO5811
SC5B8.01, probable transcriptional regulator, partial CDS, overlaps and extends SC4H2.32, len: > 140 aa; SC4H2.32, probable transcriptional regulator, partial CDS, len: >111 aa; similar to many e.g. TR:D1022772 (EMBL:D85417) HemR from Propionibacterium freudenreichii (243 aa), fasta scores; opt: 262 z-score: 366.7 E(): 3.3e-13, 46.5% identity in 101 aa overlap. Contains Pfam match to entry tetR PF00440, Bacterial regulatory proteins, tetR family, score 29.06.
  
     0.680
SCO0330
SCF12.09, probable short chain oxidoreductase, len: 249 aa; similar to many eg. TR:O86853 (EMBL:AJ007731) 3-ketoacyl-ACP/CoA reductase from Streptomyces coelicolor (244 aa) fasta scores; opt: 515, z-score: 576.2, E(): 9.6e-25, (40.2% identity in 244 aa overlap and to SW:FABG_BACSU (EMBL:U59433) Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) FabG, 246 aa; fasta scores: opt: 473 Z-score: 524.5 E(): 1.4e-21; 37.500% identity in 248 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase; Pfam match to entry PF00678 adh_short_C2, S [...]
 
     0.551
SCO6694
SC4C6.04, possible transcriptional regulator, len: 204 aa; similar to many e.g. TR:P72185 (EMBL:U51164), HemR, Propionibacterium freudenreichii repressor protein from hemYHBXRL gene cluster (involved in the biosynthetic pathway from glutamate to protoheme) (259 aa), fasta scores; opt: 205 z-score: 251.7 E(): 1.1e-06, 28.5% identity in 200 aa overlap. Contains probable helix-turn-helix motif at aa 45-66 (Score 1187, +3.23 SD). Weakly similar to others from S.coelicolor e.g. TR:O69987 (EMBL:AL022268) S.coelicolor probable transcriptional regulator, partial CDS (>111 aa) (42.4% identity i [...]
  
     0.499
SCO1193
SCG11A.24c, probable tetR-family transcriptional regulator, len: 189 aa; similar to TR:CAB56380 (EMBL:AL118515) Streptomyces coelicolor probable tetR-family transcriptional regulator SCD17.03, 226 aa; fasta scores: opt: 233 z-score: 295.6 E(): 4.3e-09; 35.2% identity in 176 aa overlap. Contains match to Pfam entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
  
     0.453
SCO0331
SCF12.10, possible short chain oxidoreductase (putative secreted protein), len: 299 aa; similar to many e.g. TR:CAB51136 (EMBL:Y18817) short chain oxidoreductase from actinorhodin biosynthesis cluster of Streptomyces coelicolor (276 aa) fasta scores; opt: 358, z-score: 403.3, E(): 4.1e-15, 34.6% identity in 280 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.413
SCO7100
SC4B10.01, probable oxidoreductase, len: 260 aa; similar to TR:Q9RK83 (EMBL:AL132662) Streptomyces coelicolor possible oxidoreductase SCF11.06, 277 aa; fasta scores: opt: 208 z-score: 258.9 E(): 5.9e-07; 25.5% identity in 243 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
  
     0.406
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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