STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0404SCF51.03, possible 2-haloalkanoic acid dehalogenase, len: 246 aa; similar to SW:HAD2_PSEPU (EMBL:D17523) Pseudomonas putida 2-haloalkanoic acid dehalogenase H-109 (EC 3.8.1.2) (L-2-haloacid dehalogenase H-109) (halocarboxylic acid halidohydrolase H-109) DehH109, 224 aa: fasta scores: opt: 275 z-score: 328.4 E(): 6.4e-11; 32.2% identity in 202 aa overlap. Contains a Pfam match to entry PF00702 hydrolase, haloacid dehalogenase-like hydrolase. (246 aa)    
Predicted Functional Partners:
SCO3446
SCE46.03c, possible dehalogenase, len: 225 aa; similar to SW:HAD_PSESP (EMBL:S74078) Pseudomonas sp. (strain YL) 2-haloalkanoic acid dehalogenase (EC 3.8.1.2), 232 aa; fasta scores: opt: 243 z-score: 288.1 E(): 1.1e-08; 23.5% identity in 217 aa overlap. Contins match to Pfam entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase.
  
  
  0.972
SCO0899
Putative hydrolase; SCM1.32, possible hydrolase, len: 298 aa. Similar to many including: Moraxella sp. SW:DEH1_MORSP (EMBL:D90422:) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa), fasta scores opt: 669 z-score: 782.5 E():0 39.2% identity in 296 aa overlap and Streptomyces coelicolor TR:O86546 (EMBL:AL031350) putative hydrolase SC1F2.09C (309 aa), fasta scores opt: 336 z-score: 396.1 E(): 1e-14 31.1% identity in 305 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
 
 
  0.926
SCO7205
Putative hydrolase; SC2H12.04, possible hydrolase, len: 286 aa. Highly similar to many including: Moraxella sp. SW:DEH1_MORSP(EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa), fasta scores opt: 556 z-score: 678.4 E(): 2.6e-30 35.6% identity in 292 aa overlap and Streptomyces coelicolor: TR:Q9RD12(EMBL:AL133422) putative hydrolase, SCM1.32 (298 aa), fasta scores opt: 653 z-score: 795.7 E(): 0 42.2% identity in 287 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
 
 
  0.920
SCO1706
SCI30A.27c, probable aldehyde dehydrogenase, len: 462 aa; similar to many e.g. TR:O33455 (EMBL:U24215) P-cumic aldehyde dehydrogenase from Pseudomonas putida Fl (494 aa) fasta scores; opt: 1109, z-score: 1142.8, E(): 0, (44.6% identity in 471 aa overlap) and TR:O88069 (EMBL:AL031541) putative aldehyde dehydrogenase from Streptomyces coelicolor (483 aa) fasta scores; opt: 1011, z-score: 1042.5, E(): 0, (41.8% identity in 466 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site.
   
 
  0.900
SCO3420
SCE9.27c, probable aldehyde dehydrogenase, len: 486 aa; highly similar to many NAD-linked aldehyde dehydrogenases e.g. SW:XYLC_PSEPU (EMBL:U15151), xylC, Pseudomonas putida benzaldehyde dehydrogenase [NAD+] from TOL plasmid pWW0 (487 aa), fasta scores; opt: 1244 z-score: 1420.3 E(): 0, 41.5% identity in 479 aa overlap. Similar to others from S.coelicolor e.g. TR:O88069 (EMBL:AL031541) probable aldehyde dehydrogenase (483 aa) (40.0% identity in 448 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 491.30, E-value 7.6e-144, PS00687 Aldehyde dehydroge [...]
   
 
  0.900
SCO4913
SCK13.05c, probable aldehyde dehydrogenase, len: aa; similar to SW:DHA5_YEAST (EMBL:X85987) Saccharomyces cerevisiae aldehyde dehydrogenase 2 (EC 1.2.1.5) Ald5, 506 aa; fasta scores: opt: 1336 z-score: 1519.8 E(): 0; 46.1% identity in 462 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00070 Aldehyde dehydrogenases cysteine active site.
   
 
  0.900
SCO5679
SC5H4.03, probable aldehyde dehydrogenase, len: 481 aa; similar to TR:O66573 (EMBL:AE000677) Aquifex aeolicus aldehyde dehydrogenase AldH1, 476 aa; fasta scores: opt: 1129 z-score: 1260.2 E(): 0; 39.9% identity in 471 aa overlap and to SW:GAPN_STRMU (EMBL:L38521) Streptococcus mutans NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9) GapN, 475 aa; fasta scores: opt: 893 z-score: 997.5 E(): 0; 35.4% identity in 477 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family.
   
 
  0.900
SCO0403
SCF51.02c, hypothetical protein, len: 187 aa; similar to various hypothetical proteins, e.g. TR:CAB56690 (EMBL:AL121596) Streptomyces coelicolor SCF51A.38 hypothetical 18.5 KD protein, 169 aa; fasta scores: opt: 176 z-score: 225.6 E(): 3.4e-05; 32.9% identity in 173 aa overlap.
 
     0.649
SCP1.54c
Putative acetaldehyde dehydrogenase (acylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
     
  0.499
SCO2330
SCC53.21, possible isochorismatase, len: 196 aa; region similar to many eg. SW:P15048 (ENTB_ECOLI) isochorismatase (EC 3.3.2.1) from Escherichia coli (285 aa) fasta scores; opt: 123, z-score: 154.2, E(): 0.41, 28.9% identity in 114 aa overlap. Also similar to TR:P96654 (EMBL:AB001488) hypothetical protein from Bacillus subtilis (180 aa) fasta scores; opt: 358, z-score: 433.4, E(): 1.1e-16, 36.7% identity in 177 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase, Isochorismatase family.
 
    0.421
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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