STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO0410Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (416 aa)    
Predicted Functional Partners:
SCO2238
NAD(+) synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.946
SCO2579
Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.942
SCO1781
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 
0.924
SCO0506
NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.918
SCO6464
Putative SIR2 family transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 
 0.916
SCO7623
SC2H2.21c, pntA, NAD(P) transhydrogenase alpha subunit, len: 524 aa; similar to SW:PNTA_ECOLI (EMBL:X04195) Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.1) PntA, 510 aa; fasta scores: opt: 1907 z-score: 1729.3 E(): 0; 58.4% identity in 514 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Also contains possible hydrophobic membrane spanning regions.
     
 0.916
SCO5186
2SC3B6.10, conserved hypothetical protein, len: 318 aa; similar to TR:O53345 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 33.8 kD protein MTV014.43c, 313 aa; fasta scores: opt: 334 z-score: 389.2 E(): 3.3e-14; 33.3% identity in 318 aa overlap.
     
 0.904
SCO7622
NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.904
SCO1782
SCI51.22c, possible membrane protein, len: 271 aa; unknown function, similar to hemolysins and hemolysin-like hypothetical proteins e.g. SW:HLYA_TREHY (EMBL:X61684), tlyA, Treponema hyodysenteriae hemolysin A (240 aa), fasta scores; opt: 457 z-score: 532.9 E(): 2.5e-22, 35.4% identity in 240 aa overlap and TR:Q50760 (EMBL:X98295), tlyA, Mycobacterium tuberculosis. Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF01479 S4, S4 domain and PS00017 ATP/GTP-binding site motif A (P-loop).
  
  
 0.735
SCO0411
Hypothetical protein SCF51.10; SCF51.10, unknown, len: 74 aa. Contains a prosite match to entry PS00017 ATP/GTP-binding site motif A (P-loop).
       0.571
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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