node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO0410 | SCO0411 | gene:17757993 | gene:17757994 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Hypothetical protein SCF51.10; SCF51.10, unknown, len: 74 aa. Contains a prosite match to entry PS00017 ATP/GTP-binding site motif A (P-loop). | 0.571 |
SCO0410 | SCO0506 | gene:17757993 | gene:17758089 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.918 |
SCO0410 | SCO1781 | gene:17757993 | gene:17759375 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.924 |
SCO0410 | SCO1782 | gene:17757993 | gene:17759376 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | SCI51.22c, possible membrane protein, len: 271 aa; unknown function, similar to hemolysins and hemolysin-like hypothetical proteins e.g. SW:HLYA_TREHY (EMBL:X61684), tlyA, Treponema hyodysenteriae hemolysin A (240 aa), fasta scores; opt: 457 z-score: 532.9 E(): 2.5e-22, 35.4% identity in 240 aa overlap and TR:Q50760 (EMBL:X98295), tlyA, Mycobacterium tuberculosis. Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF01479 S4, S4 domain and PS00017 ATP/GTP-binding site motif A (P-loop). | 0.735 |
SCO0410 | SCO2238 | gene:17757993 | gene:17759835 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | NAD(+) synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.946 |
SCO0410 | SCO2579 | gene:17757993 | gene:17760183 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.942 |
SCO0410 | SCO5186 | gene:17757993 | gene:17762835 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 2SC3B6.10, conserved hypothetical protein, len: 318 aa; similar to TR:O53345 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 33.8 kD protein MTV014.43c, 313 aa; fasta scores: opt: 334 z-score: 389.2 E(): 3.3e-14; 33.3% identity in 318 aa overlap. | 0.904 |
SCO0410 | SCO6464 | gene:17757993 | gene:17764121 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Putative SIR2 family transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.916 |
SCO0410 | SCO7622 | gene:17757993 | gene:17765282 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.904 |
SCO0410 | SCO7623 | gene:17757993 | gene:17765283 | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | SC2H2.21c, pntA, NAD(P) transhydrogenase alpha subunit, len: 524 aa; similar to SW:PNTA_ECOLI (EMBL:X04195) Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.1) PntA, 510 aa; fasta scores: opt: 1907 z-score: 1729.3 E(): 0; 58.4% identity in 514 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Also contains possible hydrophobic membrane spanning regions. | 0.916 |
SCO0411 | SCO0410 | gene:17757994 | gene:17757993 | Hypothetical protein SCF51.10; SCF51.10, unknown, len: 74 aa. Contains a prosite match to entry PS00017 ATP/GTP-binding site motif A (P-loop). | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.571 |
SCO0506 | SCO0410 | gene:17758089 | gene:17757993 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.918 |
SCO0506 | SCO1781 | gene:17758089 | gene:17759375 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.918 |
SCO0506 | SCO2238 | gene:17758089 | gene:17759835 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NAD(+) synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.910 |
SCO0506 | SCO2579 | gene:17758089 | gene:17760183 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.964 |
SCO0506 | SCO5186 | gene:17758089 | gene:17762835 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 2SC3B6.10, conserved hypothetical protein, len: 318 aa; similar to TR:O53345 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 33.8 kD protein MTV014.43c, 313 aa; fasta scores: opt: 334 z-score: 389.2 E(): 3.3e-14; 33.3% identity in 318 aa overlap. | 0.909 |
SCO0506 | SCO6464 | gene:17758089 | gene:17764121 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Putative SIR2 family transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.917 |
SCO0506 | SCO7622 | gene:17758089 | gene:17765282 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.912 |
SCO0506 | SCO7623 | gene:17758089 | gene:17765283 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | SC2H2.21c, pntA, NAD(P) transhydrogenase alpha subunit, len: 524 aa; similar to SW:PNTA_ECOLI (EMBL:X04195) Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.1) PntA, 510 aa; fasta scores: opt: 1907 z-score: 1729.3 E(): 0; 58.4% identity in 514 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Also contains possible hydrophobic membrane spanning regions. | 0.904 |
SCO1781 | SCO0410 | gene:17759375 | gene:17757993 | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.924 |