STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0464SCF76.04c, possible integral membrane protein, len: 565 aa. Similar in parts to many hypothetical proteins e.g. Streptomyces lividans TR:O86875 (EMBL; U22894) hypothetical 57.9 KD protein (547 aa), fasta scores opt: 689 z-score: 806.6 E(): 0 41.7% identity in 439 aa overlap and Streptomyces coelicolor TR:O86807 (EMBL; AL031031) putative regulatory protein (916 aa), fasta scores opt: 329 z-score: 381.2 E(): 7.1e-14 26.5% identity in 582 aa overlap. Contains a Pfam match to entry PF01590 GAF, GAF domain and possible membrane spanning hydrophobic domains. (565 aa)    
Predicted Functional Partners:
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
   0.821
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
 
   0.783
SCO7380
Conserved hypothetical protein; SC10G8.07c, unknown, len: 437 aa. Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein, SC9C7.20 (860 aa), fasta scores opt: 271 z-score: 309.7 E(): 7.7e-10 30.3% identity in 274 aa overlap.
  
     0.765
SCO0465
SCF76.05c, non-heme chloroperoxidase (chloride peroxidase), len: 276 aa. Identical to Streptomyces lividans SW:PRXC_STRLI (EMBL; U02635) non-heme chloroperoxidase (EC 1.11.1.10) (chloride peroxidase)(CPO-L) (chloroperoxidase L) (275 aa), fasta scores opt: 1866 z-score: 2162.6 E():0 99.3% identity in 275 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
  
    0.754
SCO2624
SCC80.09c, possible integral membrane protein, len: 395 aa; similar to TR:Q9RL36 (EMBL:AL121596) Streptomyces coelicolor hypothetical 29.6 kDa protein SCF51A.29c, 284 aa; fasta scores: opt: 269 z-score: 309.0 E(): 1.1e-09; 31.0% identity in 258 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.693
SCO3067
SCE25.08c, putative anti anti sigma factor, len: 125 aa; identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative anti anti sigma factor, 125 aa. Contains Pfam match to entry PF01740 SpoIIAA, SpoIIAA family; Belongs to the anti-sigma-factor antagonist family.
 
   0.691
SCP1.41c
Hypothetical protein; SCP1.41c, unknown, len: 411aa; weakly similar to many eg. TR:Q9L195 (EMBL:AL158057) hypothetical protein from Streptomyces coelicolor (437 aa) fasta scores; opt: 476, z-score: 570.6, E(): 2.6e-24, 32.7% identity in 327 aa overlap.
  
     0.634
SCP1.313
Hypothetical protein; SCP1.313, unknown, len: 411aa; weakly similar to many eg. TR:Q9L195 (EMBL:AL158057) hypothetical protein from Streptomyces coelicolor (437 aa) fasta scores; opt: 476, z-score: 570.6, E(): 2.6e-24, 32.7% identity in 327 aa overlap.
  
     0.634
SCO7747
SC8D11.38, hypothetical protein, len: 392 aa; similar to TR:Q9L195 (EMBL:AL158057) Streptomyces coelicolor hypothetical 47.1 kDa protein SC10G8.07c, 437 aa; fasta scores: opt: 419 z-score: 494.1 E(): 5.5e-20; 28.5% identity in 393 aa overlap.
  
     0.546
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
0.542
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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