STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO0509Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)    
Predicted Functional Partners:
SCO1648
AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 0.971
SCO2913
SCE19A.13c, conserved hypothetical protein, len: 140 aa; unknown function, similar to hypothetical proteins from other organisms e.g. SW:Y03J_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (146 aa), fasta scores; opt: 579 z-score: 694.1 E(): 2.5e-31, 65.0% identity in 140 aa overlap and TR:Q54330 (EMBL:M29166) Streptomyces kasugaensis CDS from Mec+ region (115 aa) (69.8% identity in 116 aa overlap).
   
 0.970
SCO0670
SCF91.30, glpD, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), len: 527 aa. Highly similar to many prokaryotic and eukaryotic glycerol-3-phosphate dehydrogenases including: Mycobacterium tuberculosis SW:GLPD_MYCTU (EMBL:Z70692) (516 aa), fasta scores opt: 1648 z-score: 1727.9 E():0 52.6% identity in 513 aa overlap and Caenorhabditis elegans SW:GPDM_CAEEL(EMBL:Z73906) (722aa), fasta score opt: 668 z-score: 700.9 E(): 1.2e-31 33.9% identity in 537 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and a Prosite hit to PS00 [...]
 
 0.969
SCO1659
Putative glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family.
 
 
 0.967
SCO4774
SCD63.06, probable glycerol phosphate dehydrogenase, len: 568 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 815 z-score: 910.2 E(): 0; 32.1% identity in 546 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and match to Prosite entry PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2.
 
 0.955
SCO1643
20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family.
   
 0.943
SCO1644
20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity.
   
 0.943
SCO1661
SCI52.03, probable glycerol-3-phosphate dehydrogenase, len: 538 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 751 Z-score: 835.1 bits: 164.3 E(): 6.1e-39; 30.830% identity in 506 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase.
 
 0.940
SCO1788
SCI51.28c, conserved hypothetical protein, len: 343 aa; unknown function, similar to other hypothetical proteins e.g. TR:O33194 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (353 aa), fasta scores; opt: 768 z-score: 825.7 E(): 0, 44.8% identity in 315 aa overlap, with SCI51.28c. Also shows weak similarity to SW:NAGD_ECOLI (EMBL:X14135), nagD, a CDS in the Escherichia coli N-acetylglucosamine operon (250 aa) (26.7% identity in 243 aa overlap) and to SW:PNPP_SCHPO (EMBL:X62722) Schizosaccharomyces pombe 4-nitrophenylphosphatase (unknown physiological substrate) (269 aa) ( [...]
  
 
 0.912
SCO4271
SCD95A.04, probable NADP-dependent alcohol dehydrogenase, len: 378 aa; similar to SW:ADH_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis NADP-dependent alcohol dehydrogenase (EC 1.1.1.2) Adh, 346 aa; fasta scores: opt: 986 z-score: 1074.5 E(): 0; 45.0% identity in 349 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and match to Prosite entry PS00059 Zinc-containing alcohol dehydrogenases signature.
    
 0.907
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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