STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0676SCF91.36, possible integral membrane sensor protein, len: 864 aa. Similar in the N-terminus to several sensory transduction histidine kinases e.g. Escherichia coli SW:DCUS_ECOLI(EMBL:U14003) sensor protein DcuS (EC 2.7.3.-) (543 aa), fasta scores opt: 499 z-score: 546.9 E(): 4.4e-23 30.8% identity in 331 aa overlap. Highly similar in the C-terminus to several proteins from Streptomyces coelicolor including: TR:CAB41270(EMBL:AL049707) conserved hypothetical protein (fragment) (>436 aa), fasta scores opt: 1207 z-score: 1324.9 E():0 48.0% identity in 423 aa overlap and TR:CAB44394(EMBL:AL [...] (864 aa)    
Predicted Functional Partners:
SCO5748
SC7C7.03, probable sensory histidine kinase, len: 1829 aa; N-terminus has 11 92aa repeats. Highly similar to putative osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus putative histidine kinase (1298 aa), fasta scores; opt: 2011 z-score: 1764.6 E(): 0, 38.3% identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat), fasta scores; opt: 378 z-score: 755.8, E(): 0, 28.9% identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphoryl [...]
  
 
 0.900
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
0.883
SCO7327
SC4G10.06c, possible two-component system sensory histidine kinase, len: 1331 aa. Highly similar in parts to many including: Pseudomonas syringae (pv. syringae) SW:LEMA_PSESY(EMBL:M80477) sensor protein, LemA (EC 2.7.3.-), (907 aa), fasta scores opt: 641 z-score: 627.6 E(): 1.7e-27 31.2% identity in 872 aa overlap and Streptomyces coelicolor TR:O86808(EMBL:AL031031) putative sensory histidine kinase, SC7C7.03 (1829 aa), fasta scores opt: 2600 z-score: 2540.8 E():0 59.1% identity in 1346 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domai [...]
  
 
 0.868
SCO5434
SC6A11.10c, possible two-component response regulator, len: 230 aa; similar to many e.g. SW:Q54149 (DPIA_ECOLI) transcriptional regulatory protein DpiA from Escherichia coli (226 aa) fasta scores: opt: 393, z-score: 440.6, E(): 3.9e-17, 33.8% identity in 222 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain and a helix-turn-helix motif score 1515 (+4.35 SD) in ID at residue 179.
 
 
 0.810
SCO1136
2SCG38.29c, probable two component system response regulator, len: 263 aa; similar to SW:DCUR_ECOLI (EMBL:U14003) Escherichia coli transcriptional regulatory protein DcuR, 239 aa; fasta scores: opt: 421 z-score: 469.7 E(): 1e-18; 35.0% identity in 226 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain and possible helix-turn-helix motif at residues 201.222 (+3.87 SD).
 
 
 0.790
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
   0.777
SCO5828
SC5B8.18c, probable two-component transcriptional regulator, len: 226 aa; similar to many e.g. CITB_KLEPN P5268 8 transcriptional regulator from klebsiella pneumoniae (23 4 aa), fasta scores; opt: 319 z-score: 394.9 E(): 8.3e-15, 30.8% identity in 224 aa overlap. Contains Pfam match to entry response_reg PF00072, Response regulator receiver domain, score 117.43 and probable helix-turn-helix from aa 176- 197 (Score 2073, +6.25 SD).
 
 
 0.773
SCO2817
SCBAC17F8.08c, conserved hypothetical protein, len: 634 aa: similar in regions to many proteins of varying lengths e.g. TR:Q9RCY2 (EMBL:AL133469) hypothetical protein SCM10.16c from Streptomyces coelicolor (714 aa) fasta scores; opt: 1259, Z-score: 1358.4, 43.960% identity (46.454% ungapped) in 596 aa overlap and TR:Q9HVI8 (EMBL:AE004874) hypothetical protein from Pseudomonas aeruginosa (1415 aa) fasta scores; opt: 961, Z-score: 1032.5, 36.825% identity (40.250% ungapped) in 611 aa overlap. Contains Pfam match to entry PF00563 EAL, Domain of unknown function and Pfam match to entry PF0 [...]
  
  
 0.693
SCO3284
SCE15.01, partial CDS, conserved hypothetical protein, len: >436aa; similar to C-terminal region of TR:CAA22732 (EMBL:AL035161) another conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores; opt: 922, z-score: 1011.5, E(): 0, (39.5% identity in 425 aa overlap); SCE39.34, unknown, len: >307aa; similar to TR:E1370406 (EMBL:AL035161) conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores; opt: 254, z-score: 277.0, E(): 4e-08, (29.2% identity in 277 aa overlap) TR:O86875 (EMBL:U22894) hypothetical protein from Streptomyces lividans (54 [...]
 
 
0.683
SCO5933
SC7H1.03c, possible membrane protein, len: 391 aa; C-terminal part similar to TR:Q9L0E7 (EMBL:AL161803) Streptomyces coelicolor hypothetical protein SCD31.20, 181 aa; fasta scores: opt: 592 Z-score: 665.9 E(): 1.8e-29; 53.514% identity in 185 aa overlap. Contains possible hydrophobic membrane spanning regions. Contains PS00213 Lipocalin signature, though this may be spurious.
 
     0.669
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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