STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0895RNA polymerase principal sigma factor HrdC; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (339 aa)    
Predicted Functional Partners:
SCO4654
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.969
SCO4729
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.966
SCO4655
DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.958
SCO1421
Hypothetical protein SC6D7.18c; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Stimulates transcription from several principal sigma factor HrdB (SigA)-dependent promoters but not from a SigR-dependent promoter. Stimulation occurs in the presence of the transcription initiation inhibitor rifampicin (Rif).
    
 
 0.935
SCO1478
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
   
 
 0.925
SCO4232
SCD8A.05, probable transcriptional factor regulator, len: 160 aa; similar to TR:O53568 (EMBL:AL022075) Mycobacterium tuberculosis putative transcriptional regulator RV3583c, 162 aa; fasta scores: opt: 878 z-score: 1046.7 E(): 0; 85.0% identity in 160 aa overlap.
   
 
 0.898
SCO0140
SCJ33.04, possible merR-family transcriptional regulator, len: 275 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB56383 (EMBL; AL118515) putative merR family transcriptional regulator SCD17.06C (319 aa), fasta scores opt: 164 z-score: 194.6 E(): 0.0018 28.9% identity in 298 aa overlap and Bacillus subtilis SW:BLTR_BACSU (EMBL; L32599) multidrug-efflux transporter 2 regulator (273 aa), fasta scores opt: 154 z-score: 184.2 E(): 0.0069 21.3% identity in 253 aa overlap. Contains a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. Contains a possible h [...]
  
 
 0.875
SCO4443
SCD6.21c, possible merR-family transcriptional regulator, len: 294 aa; similar to TR:AAF11989 (EMBL:AE002074) Deinococcus radiodurans transcriptional regulator, merR-family DR2448, 280 aa; fasta scores: opt: 465 z-score: 562.4 E(): 7.3e-24; 43.0% identity in 286 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and match to Prosite entry PS00552 Bacterial regulatory proteins, merR family signature.
  
 
 0.875
SCO4223
2SCD46.37c, possible AraC-family transcriptional regulator, len: 295aa; similar to many eg. SW:P22539 (SOXS_ECOLI) regulatory protein SoxS from Escherichia coli (106 aa) fasta scores; opt: 186, z-score: 223.7, E(): 5.4e-05, 28.4% identity in 95 aa overlap and TR:P96662 (EMBL:AB001488) probable hth_arac_family of transcriptional regulator from Bacillus subtilis (290 aa) fasta scores; opt: 726, z-score: 825.6, E(): 0, 37.7% identity in 289 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and Prosite match to PS00041 Ba [...]
    
 
 0.851
SCO5190
Putative DNA-binding protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
    
   0.832
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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