STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0946Putative regulatory protein; SCM11.01c, hypothetical protein, len: >587 aa; similar to various hypothetical proteins, e.g. TR:Q9ZBJ0 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.20, 860 aa; fasta scores: opt: 588 z-score: 654.5 E(): 4.4e-29; 30.4% identity in 542 aa overlap; SCM10.35c, possible regulatory protein, (partial CDS), len: >141 aa; similar to TR:Q9ZBT2 (EMBL:AL034446)Streptomyces coelicolor putative regulatory protein SC1A9.20, 135 aa; fasta scores: opt: 286 z-score: 366.0 E(): 5.3e-13; 42.4% identity in 132 aa overlap. (696 aa)    
Predicted Functional Partners:
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
   0.817
SCO7380
Conserved hypothetical protein; SC10G8.07c, unknown, len: 437 aa. Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein, SC9C7.20 (860 aa), fasta scores opt: 271 z-score: 309.7 E(): 7.7e-10 30.3% identity in 274 aa overlap.
  
     0.768
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
 
   0.764
SCO6390
SC3C8.09, probable integral membrane protein, len: 367 aa; similar to a hypothetical protein from M. tuberculosis Y07S_MYCTU MTCY02B10.28c (653 aa), fatsta scores; opt: 144 z-score: 314.2 E(): 2.9e-10, 30.6% identity in 281 aa overlap. Also similar to S. coelicolor SC7H1.03c (E(): 3e-18, 35.2% identity in 355 aa overlap).
  
     0.759
SCO5933
SC7H1.03c, possible membrane protein, len: 391 aa; C-terminal part similar to TR:Q9L0E7 (EMBL:AL161803) Streptomyces coelicolor hypothetical protein SCD31.20, 181 aa; fasta scores: opt: 592 Z-score: 665.9 E(): 1.8e-29; 53.514% identity in 185 aa overlap. Contains possible hydrophobic membrane spanning regions. Contains PS00213 Lipocalin signature, though this may be spurious.
  
     0.747
SCO3067
SCE25.08c, putative anti anti sigma factor, len: 125 aa; identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative anti anti sigma factor, 125 aa. Contains Pfam match to entry PF01740 SpoIIAA, SpoIIAA family; Belongs to the anti-sigma-factor antagonist family.
 
   0.706
SCO1327
2SCG61.09, possible integral membrane protein, len: 387 aa; similar to many predicted integral membrane protein especially others from Streptomyces coelicolor e.g. TR:CAB69689 (EMBL:AL137165) putative integral membrane protein (375 aa) fasta scores; opt: 481, z-score: 562.8, E(): 7.2e-24, 35.7% identity in 387 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
     0.696
SCO7747
SC8D11.38, hypothetical protein, len: 392 aa; similar to TR:Q9L195 (EMBL:AL158057) Streptomyces coelicolor hypothetical 47.1 kDa protein SC10G8.07c, 437 aa; fasta scores: opt: 419 z-score: 494.1 E(): 5.5e-20; 28.5% identity in 393 aa overlap.
  
     0.655
SCO0945
SCM10.34c, probable formamidopyrimidine-DNA glycosylase len: 287 aa; similar to TR:P71565 (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 16.5k kD protein MTYC10D7.30c, 158 aa; fasta scores: opt: 608 z-score: 707.4 E(): 5.2e-32; 59.0% identity in 156 aa overlap and to SW:FPG_SYNEN (EMBL:Y10290) Synechococcus elongatus naegeli formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) MutM, 284 aa; fasta scores: opt: 426 z-score: 495.1 E(): 3.4e-20; 33.6% identity in 283 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase.
       0.645
SCO4410
SC6F11.08, possible anti anti sigma factor, len: 126 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist BldG, 113 aa; fasta scores: opt: 195 z-score: 264.4 E(): 3.2e-07; 30.8% identity in 104 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
 
   0.579
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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